06213nas a2200217 4500008004100000022001400041245009500055210006900150260000800219300001400227490000800241520546200249100002405711700002105735700001705756700001905773700001905792700002105811700001805832856014505850 2020 eng d a1520-610600aReply to “comment on ‘arresting an unusual amide tautomer using divalent cations’”0 aReply to comment on arresting an unusual amide tautomer using di cDEC a479–4830 v1253 a

In our publication, we assigned the blue-shifted shoulder of N-methylacetamide (NMA) in the infrared (IR) spectrum (∼1645 cm–1) to an iminolate tautomer stabilized in the presence of divalent metal cations (e.g., 5 M Ca2+).(1) Cremer and co-workers comment that this shoulder arises from the dehydration of the amide oxygen upon interaction with the metal cations.(2,3) Their assignment is based on three interesting experimental observations: (1) the IR spectrum of 15N-isotope-labeled NMA does not show any considerable red-shift compared to that of NMA; (2) a new peak appears for NMA at 1680 cm–1 in the presence of 1 M DCl, which shows a 17 cm–1 red-shift for 15N-labeled NMA; and (3) the IR spectrum of acetone C═O stretch also demonstrates a blue-shifted shoulder in the presence of a high concentration of CaCl2.

1 aKashid, Somnath, M.1 aSingh, Reman, K.1 aKwon, Hyejin1 aSeol, Jin, Gyu1 aKim, Yung, Sam1 aMukherjee, Arnab1 aBagchi, Sayan uhttps://library.ncl.res.in/content/reply-%E2%80%9Ccomment-%E2%80%98arresting-unusual-amide-tautomer-using-divalent-cations%E2%80%99%E2%80%9D