04532nas a2200169 4500008004100000245010000041210006900141260000800210300001400218490000600232520390100238100002304139700003004162700002504192700002004217856012504237 2021 eng d00aAspergillus derived mycotoxins in food and the environment: prevalence, detection, and toxicity0 aAspergillus derived mycotoxins in food and the environment preva cJAN a1008-10300 v83 a

Aspergillus species are the paramount ubiquitous fungi that contaminate various food substrates and produce biochemicals known as mycotoxins. Aflatoxins (AFTs), ochratoxin A (OTA), patulin (PAT), citrinin (CIT), aflatrem (AT), secalonic acids (SA), cyclopiazonic acid (CPA), terrein (TR), sterigmatocystin (ST) and gliotoxin (GT), and other toxins produced by species of Aspergillus plays a major role in food and human health. Mycotoxins exhibited wide range of toxicity to the humans and animal models even at nanomolar (nM) concentration. Consumption of detrimental mycotoxins adulterated foodstuffs affects human and animal health even trace amounts. Bioaerosols consisting of spores and hyphal fragments are active elicitors of bronchial irritation and allergy, and challenging to the public health. Aspergillus is the furthermost predominant environmental contaminant unswervingly defile lives with a 40–90 % mortality risk in patients with conceded immunity. Genomics, proteomics, transcriptomics, and metabolomics approaches useful for mycotoxins’ detection which are expensive. Antibody based detection of toxins chemotypes may result in cross-reactivity and uncertainty. Aptamers (APT) are single stranded DNA (ssDNA/RNA), are specifically binds to the target molecules can be generated by systematic evolution of ligands through exponential enrichment (SELEX). APT are fast, sensitive, simple, in-expensive, and field-deployable rapid point of care (POC) detection of toxins, and a better alternative to antibodies.

1 aNavale, Vishwambar1 aVamkudoth, Koteswara, Rao1 aAjmera, Shanthipriya1 aDhuri, Vaibhavi uhttps://library.ncl.res.in/content/aspergillus-derived-mycotoxins-food-and-environment-prevalence-detection-and-toxicity