01324nas a2200217   4500008004100000022001400041245009000055210006900145260010600214300001000320490000700330520048900337653002100826653003100847653003400878653001400912653001500926100002300941700002200964856012000986       2016                        eng d  a0040-403900aFormal total synthesis of anti-helicobacter pylori agent (+)-spirolaxine methyl ether0 aFormal total synthesis of antihelicobacter pylori agent spirolax  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a25-280 v573 a<p>A convergent, formal enantioselective synthesis of anti-Helicobacter pylori agent, (+)-spirolaxine methyl ether 2 has been achieved in high enantiomeric purity starting from commercially available 1,5-pentanediol. The strategy mainly comprises of the Noyori's asymmetric reduction and Brown allylation/Cu-catalyzed lactonization as the key step for the construction of key chiral intermediates, spiroketal 3 and phthalide fragment 4. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aBrown allylation10aCu-catalyzed lactonization10aNoyori's asymmetric reduction10aPhthalide10aSpiroketal1 aGadakh, Sunita, K.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-total-synthesis-anti-helicobacter-pylori-agent-spirolaxine-methyl-ether-0