02341nas a2200289   4500008004100000022001400041245007400055210006900129260000900198300001100207490000700218520144200225653001601667653002601683653002301709653002101732653003201753100002101785700002101806700002301827700002001850700001901870700002001889700002201909700001901931856010101950       2021                        eng d  a1664-302X00aAntimicrobial synergy of silver-platinum nanohybrids with antibiotics0 aAntimicrobial synergy of silverplatinum nanohybrids with antibio  cFEB   a6109680 v113 a<p>Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100 degrees C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of similar to 59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of -14.46, -1.09, and -11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.</p>
10aantibiofilm10aantimicrobial synergy10abiogenic synthesis10aCharacterization10asilver-platinum nanohybrids1 aRanpariya, Bansi1 aSalunke, Gayatri1 aKarmakar, Srikanta1 aBabiya, Kaushik1 aSutar, Santosh1 aKadoo, Narendra1 aKumbhakar, Pathik1 aGhosh, Sougata  uhttps://library.ncl.res.in/content/antimicrobial-synergy-silver-platinum-nanohybrids-antibiotics