02370nas a2200253   4500008004100000022001400041245019400055210006900249260000800318300001200326490000600338520140500344100002601749700002501775700002201800700002301822700002101845700001801866700002201884700002401906700002801930700002601958856013201984       2021                        eng d  a2047-483000aGreen synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo0 aGreen synthesis of methoxypolyethylene glycolblockpolyllactideco  cFEB  a795-8060 v93 a<p>Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (similar to-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween (R) 80 coated NP-Ir, the Pluronic (R) F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery.</p>
1 aGiram, Prabhanjan, S.1 aWang, Julie, Tzu-Wen1 aWalters, Adam, A.1 aRade, Priyanka, P.1 aAkhtar, Muhammad1 aHan, Shunping1 aFaruqu, Farid, N.1 aAbdel-Bar, Hend, M.1 aGarnaik, Baijayantimala1 aAl-Jamal, Khuloud, T.  uhttps://library.ncl.res.in/content/green-synthesis-methoxy-polyethylene-glycol-block-polyl-lactide-co-glycolide-copolymer-using