01359nas a2200229 4500008004100000022001400041245012200055210006900177260000900246300001200255490000700267520057100274653002600845653001500871653002300886653001400909653001300923100002600936700002500962700002000987856012201007 2020 eng d a0039-788100aPalladium-catalyzed oxidative annulation of pyrrolylalkyl-1H-azoles: towards the synthesis of polyheterocyclic arenes0 aPalladiumcatalyzed oxidative annulation of pyrrolylalkyl1Hazoles cMAR  a719-7260 v523 a

A highly efficient and regioselective palladium-catalyzed annulation protocol for a series of linear and terminally substituted 1,2- and 1,3-di(heteroaryl)alkanes to the corresponding polyheterocyclic arenes is reported. Herein, intramolecular oxidative coupling involving double C(sp(2))-H bond functionalization provides a feasible access to biheteroaryl systems annulated to a six-membered ring. The methodology is not restricted to six-membered annulations and was extended to the synthesis of compounds with a seven-membered ring and biheteroaryl core.

10aC-H functionalization10aimidazoles10aoxidative coupling10aPalladium10apyrroles1 aTripathi, Krishna, N.1 aBansode, Avinash, H.1 aSingh, Ravi, P. uhttps://library.ncl.res.in/content/palladium-catalyzed-oxidative-annulation-pyrrolylalkyl-1h-azoles-towards-synthesis