01812nas a2200205   4500008004100000022001400041245007800055210006900133260000900202490000700211520115000218653001401368653001301382653001901395653002901414653001701443100001901460700002001479856010701499       2024                        eng d  a1867-388000aChemodivergent dehydrogenative coupling of alcohols by 3d metal catalysts0 aChemodivergent dehydrogenative coupling of alcohols by 3d metal   cJUN 0 v163 a<p>
	Chemodivergent synthesis by transition metal catalysts is a straightforward and sustainable approach to achieving valuable organic compounds. Especially, the chemodivergent dehydrogenative couplings of alcohols with organic motifs to develop various saturated and unsaturated compounds are highly environmentally benign due to the reduced waste generation. In this concept review, we presented the 3d transition metal (Mn, Fe, Co, and Ni)-catalyzed chemodivergent synthesis of imines and amines, saturated and unsaturated carbonyl/alcohol compounds, saturated and unsaturated nitriles, N-heterocycles, and N-/C-alkylated indoles. The discussed reaction commanded two or three different products with high chemoselectivity by changing specific reaction parameters, but keeping the catalyst unchanged. Generally, the acceptorless dehydrogenative coupling (ADC) provides unsaturated moieties, whereas the borrowing-hydrogen (BH) process results in saturated compounds. Text for Table of Contents: An overview of the chemodivergent dehydrogenative coupling of alcohols by the Earth-abundant transition metal catalysts is discussed. image</p>
10a3d metals10aAlcohols10achemodivergent10adehydrogenative coupling10aheterocycles1 aBansal, Sadhna1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/chemodivergent-dehydrogenative-coupling-alcohols-3d-metal-catalysts02047nas a2200205   4500008004100000022001400041245014200055210006900197260000800266490000700274520126400281653001301545653002901558653002901587653001101616653003501627100001901662700002001681856014001701       2024                        eng d  a0947-653900aNickel-catalyzed chemodivergent coupling of alcohols: efficient routes to access α,α-disubstituted ketones and α-substituted chalcones0 aNickelcatalyzed chemodivergent coupling of alcohols efficient ro  cMAR0 v303 a<p>
	Chemodivergent (de)hydrogenative coupling of primary and secondary alcohols is achieved utilizing an inexpensive nickel catalyst, (6-OH-bpy)NiCl2. This protocol demonstrates the synthesis of branched carbonyl compounds, alpha,alpha-disubstituted ketones, and alpha-substituted chalcones via borrowing hydrogen strategy and acceptorless dehydrogenative coupling, respectively. A wide range of aryl-based secondary alcohols are coupled with various primary alcohols in this tandem dehydrogenation/hydrogenation reaction. The nickel catalyst, along with KOtBu or K2CO3, governed the selectivity for the formation of branched saturated ketones or chalcones. A preliminary mechanistic investigation confirms the reversible dehydrogenation of alcohols to carbonyls via metal-ligand cooperation (MLC) and the involvement of radical intermediates during the reaction. The chemodivergent nickel-catalyzed approach provides alpha,alpha-disubstituted ketones from aryl-substituted secondary alcohols and benzyl alcohols via the borrowing hydrogen (BH) strategy in the presence of KOtBu, whereas exclusively alpha-substituted chalcones were accomplished in the presence of mild base K2CO3 through an acceptorless dehydrogenative coupling (ADC) strategy. image</p>
10aAlcohols10adehydrogenative coupling10aMetal-ligand cooperation10aNickel10asubstituted carbonyl compounds1 aBansal, Sadhna1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/nickel-catalyzed-chemodivergent-coupling-alcohols-efficient-routes-access-%CE%B1%CE%B1-disubstituted