02047nas a2200205   4500008004100000022001400041245014200055210006900197260000800266490000700274520126400281653001301545653002901558653002901587653001101616653003501627100001901662700002001681856014001701       2024                        eng d  a0947-653900aNickel-catalyzed chemodivergent coupling of alcohols: efficient routes to access α,α-disubstituted ketones and α-substituted chalcones0 aNickelcatalyzed chemodivergent coupling of alcohols efficient ro  cMAR0 v303 a<p>
	Chemodivergent (de)hydrogenative coupling of primary and secondary alcohols is achieved utilizing an inexpensive nickel catalyst, (6-OH-bpy)NiCl2. This protocol demonstrates the synthesis of branched carbonyl compounds, alpha,alpha-disubstituted ketones, and alpha-substituted chalcones via borrowing hydrogen strategy and acceptorless dehydrogenative coupling, respectively. A wide range of aryl-based secondary alcohols are coupled with various primary alcohols in this tandem dehydrogenation/hydrogenation reaction. The nickel catalyst, along with KOtBu or K2CO3, governed the selectivity for the formation of branched saturated ketones or chalcones. A preliminary mechanistic investigation confirms the reversible dehydrogenation of alcohols to carbonyls via metal-ligand cooperation (MLC) and the involvement of radical intermediates during the reaction. The chemodivergent nickel-catalyzed approach provides alpha,alpha-disubstituted ketones from aryl-substituted secondary alcohols and benzyl alcohols via the borrowing hydrogen (BH) strategy in the presence of KOtBu, whereas exclusively alpha-substituted chalcones were accomplished in the presence of mild base K2CO3 through an acceptorless dehydrogenative coupling (ADC) strategy. image</p>
10aAlcohols10adehydrogenative coupling10aMetal-ligand cooperation10aNickel10asubstituted carbonyl compounds1 aBansal, Sadhna1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/nickel-catalyzed-chemodivergent-coupling-alcohols-efficient-routes-access-%CE%B1%CE%B1-disubstituted