02262nas a2200217   4500008004100000022001400041245011000055210006900165260000900234300001500243490000700258520148900265100002801754700002601782700002101808700001601829700002801845700002401873700001901897856012801916       2020                        eng d  a0305-104800aTDR Targets 6: driving drug discovery for human pathogens through intensive chemogenomic data integration0 aTDR Targets 6 driving drug discovery for human pathogens through  cJAN   aD992-D10050 v483 a<p>The volume of biological, chemical and functional data deposited in the public domain is growing rapidly, thanks to next generation sequencing and highly-automated screening technologies. These datasets represent invaluable resources for drug discovery, particularly for less studied neglected disease pathogens. To leverage these datasets, smart and intensive data integration is required to guide computational inferences across diverse organisms. The TDR Targets chemogenomics resource integrates genomic data from human pathogens and model organisms along with information on bioactive compounds and their annotated activities. This report highlights the latest updates on the available data and functionality in TDR Targets 6. Based on chemogenomic network models providing links between inhibitors and targets, the database now incorporates network-driven target prioritizations, and novel visualizations of network subgraphs displaying chemical- and target-similarity neighborhoods along with associated target-compound bioactivity links. Available data can be browsed and queried through a new user interface, that allow users to perform prioritizations of protein targets and chemical inhibitors. As such, TDR Targets now facilitates the investigation of drug repurposing against pathogen targets, which can potentially help in identifying candidate targets for bioactive compounds with previously unknown targets. TDR Targets is available at https://tdrtargets.org.</p>
1 aLandaburu, Lionel, Uran1 aBerenstein, Ariel, J.1 aVidela, Santiago1 aMaru, Parag1 aShanmugam, Dhanasekaran1 aChernomoretz, Ariel1 aAguero, Fernan  uhttps://library.ncl.res.in/content/tdr-targets-6-driving-drug-discovery-human-pathogens-through-intensive-chemogenomic-data