01393nas a2200205 4500008004100000022001400041245014000055210006900195260000800264300001200272490000700284520064200291100001800933700001700951700002000968700001900988700002501007700002601032856012901058 2020 eng d a0022-326300aFunctionalization of alkynes and alkenes using a cascade reaction approach: synthesis of beta-keto sulfones under metal-free conditions0 aFunctionalization of alkynes and alkenes using a cascade reactio cJAN a716-7250 v853 a

Here, we are reporting a multicomponent cascade reaction approach for the synthesis of beta-keto sulfones by exploiting differential reactivity pattern of substrates under open-atmosphere and metal-free conditions. The coupling partners are aryldiazonium salts, unsaturated compounds, and DABSO. The optimized conditions worked well with both alkenes and alkynes. Moreover, the reaction also works with metabisulfite for the source of sulfone. The controlled liquid chromatography-mass spectrometry and O-18-labelled experiments suggested that air is a source of the incoming oxygen atom of the keto group of beta-keto sulfones.

1 aKumar, Mukesh1 aAhmed, Riyaz1 aSingh, Maninder1 aSharma, Shweta1 aThatikonda, Thanusha1 aSingh, Parvinder, Pal uhttps://library.ncl.res.in/content/functionalization-alkynes-and-alkenes-using-cascade-reaction-approach-synthesis-beta-keto02467nas a2200265 4500008004100000022001400041245013400055210006900189260000900258300001100267490000800278520159800286653002201884653001301906653001901919653001101938653001701949653001401966100002701980700001802007700001902025700001902044700001302063856012502076 2022 eng d a0016-236100aSelective production of C9 monomeric phenols via hydrogenolysis of lignin using Pd-(W/Zr/Mo oxides)-supported on biochar catalyst0 aSelective production of C9 monomeric phenols via hydrogenolysis  cJAN  a1218180 v3083 aValorizing lignin to phenolic monomers and fine chemicals is an essential component of a sustainable biorefinery that uses lignocellulosic feedstocks. In this study, Pd-metal oxides (ZrO2, WOx, MoO3) supported on activated biochar (ABC) catalysts were developed for hydrogenolysis of lignin. The metals (2% Pd, 5% Zr, 5% W, 5% Mo) were supported on activated biochar using the wetness impregnation method, and the catalysts were extensively characterized. The effect of addition of secondary metals on active surface properties such as acidity, Pd metal particle size and dispersion were also evaluated. The selectivity to C9 monomeric phenols followed the trend: 2Pd-5Mo/ABC (57.3%) > 2Pd-5Zr/ABC (49.2%) > 2Pd-5W/ABC (45%) > 2Pd/ABC (42.9%). The maximum C9 phenolic monomer yield achieved in this study was similar to 22 wt%. The fractional conversion of lignin was 67-69% with Pd-metal oxide catalysts. The presence of Mo in the catalyst inhibited the hydrogenation of aliphatic C-alpha = C-beta in lignin and led to the formation of t-isoeugenol, while the presence of W and Zr resulted in selective formation of the hydrogenated product, propyl guaiacol. Using model compounds, it is proved that the formation of propyl guaiacol is via hydrogenation of t-isoeugenol, and not through dehydroxylation of propanol guaiacol. The dehydroxylation activity of the catalysts is attributed to the higher Lewis acidity and electropositive nature of the metals. A notable carbon atom economy of 47-50% towards total phenolic monomers was achieved with 2Pd/ABC, 2Pd-5Mo/ABC and 2Pd-5Zr/ABC catalysts.10aActivated biochar10aGuaiacol10aHydrogenolysis10alignin10aMetal oxides10aPalladium1 aGurrala, Lakshmiprasad1 aKumar, Midhun1 aSharma, Shweta1 aPaek, Changyub1 aVinu, R. uhttps://library.ncl.res.in/content/selective-production-c9-monomeric-phenols-hydrogenolysis-lignin-using-pd-wzrmo-oxides01922nas a2200289 4500008004100000022001400041245012100055210006900176260000900245300001100254490000800265520098600273653001601259653002601275653001801301653001001319653001401329653001701343653000801360100002101368700001901389700002201408700002601430700002001456700002601476856013001502 2023 eng d a2468-823100aNitric acid free cyclohexane to adipic acid production using nickel and vanadium incorporated AlPO-5 molecular sieve0 aNitric acid free cyclohexane to adipic acid production using nic cAPR  a1130510 v5403 a

Rationally designing a stable and sustainable metal oxide supported over the molecular sieve catalysts for oxidizing cyclohexane (CYH) to adipic acid (AA) is vital in industrial applications. The in-situ hydrothermal synthesis method successfully incorporated vanadium and nickel into the aluminium phosphate-5 (AlPO-5) molecular sieves (MFI structure). The XPS and NH3 TPD analysis disclosed that the addition of Ni into V-AlPO-5 stabilizes the ratio of V4+/V5+, creating strong acidic sites and the formation of NiOOH, which are a vital role for the selective CYH oxidation to AA. An in-situ DRIFT study reveals that nickel takes part in the formation of dicarboxylate ions as an intermediate to form AA. Our catalytic studies profoundly suggested that the Ni0.1V0.2AlPO-5 catalyst used for CYH oxidation gives better selectivity towards AA (53%) in the presence of oxygen at an appropriate amount of solvent without an initiator or promoter within a short time (3h).

10aAdipic Acid10aCyclohexane oxidation10aIn situ DRIFT10aNiOOH10aNiVAlPO-510aRatios ofV4+10aV5+1 aPrabu, Marimuthu1 aSharma, Shweta1 aRaja, Abhishekram1 aArchana, Ramakrishnan1 aSamruddhi, Mane1 aRaja, Thirumalaiswamy uhttps://library.ncl.res.in/content/nitric-acid-free-cyclohexane-adipic-acid-production-using-nickel-and-vanadium-incorporated03461nas a2200301 4500008004100000022001400041245012200055210006900177260000800246300001200254490000700266520249900273653002002772653001202792653002002804653001802824653001202842100002102854700001902875700001902894700001702913700002102930700002202951700001602973700001702989700002803006856012503034 2026 eng d a2328-895700aTargeted genomic surveillance unveils genetic variations linked to regional malaria drug resistance dynamics in India0 aTargeted genomic surveillance unveils genetic variations linked  cMAR aofag1060 v133 a

Background India has made substantial progress in reducing Plasmodium falciparum malaria cases and has set a target to eliminate malaria by 2030. Although artemisinin-based combination therapy (ACT) treatment remains effective, tracking regional differences in genetic variants associated with antimalarial resistance is required for effective drug policy implementation.Methods We analyzed 238 P. falciparum clinical samples from 6 Indian states by sequencing 15 parasite genes associated with reduced drug effectiveness. The method involved nanopore sequencing of target gene amplicons derived from dried blood spots using a highly-sensitive PfMDR15 surveillance panel.Results India's historical policy of artesunate-sulfadoxine-pyrimethamine in central India and artemether-lumefantrine in the Northeast has shaped contrasting resistance profiles. In the Northeast, chloroquine resistance persisted at high frequency (Pfcrt K76T and CVIET haplotype; Pfaat1 S258L), alongside quintuple and sextuple Pfdhfr-Pfdhps haplotypes conferring complete sulfadoxine-pyrimethamine resistance. Central India showed variable chloroquine resistance (parasites largely retained wild-type Pfcrt) and emerging lumefantrine tolerance (Pfmdr1 Y184F, Pfaat1 S258L). Interestingly, Delhi (Central India) parasites resembled profiles from the distant Northeast, which borders South East Asia. The detection of Pfaat1 S258L, previously reported only from Africa and associated with reduced lumefantrine susceptibility, suggests convergent evolution under ACT partner-drug pressure. No WHO-validated Pfk13 artemisinin resistance mutations were detected, supporting continued efficacy of ACT.Conclusions India's resistance landscape is fragmented, with signals of expanding lumefantrine tolerance and importation or evolution of globally relevant mutations. These findings highlight the importance of integrating molecular genomic surveillance into malaria control policy to monitor and protect ACT effectiveness and advance malaria elimination. Monitoring of drug resistance associated mutations in P. falciparum parasites is critical for effective drug treatment. We have demonstrated the use of a scalable genomic surveillance protocol for tracking drug resistance linked mutations in parasite genes from clinical isolates in India. The study suggests extensive regional diversity in antimalarial resistance profiles and provides the first hint of possible emergence of lumefantrine tolerance in India.

10adrug resistance10amalaria10aOxford nanopore10aP. falciparum10apfMDR151 aKhilari, Ajinkya1 aSharma, Shweta1 aBajpai, Manali1 aViswan, Anju1 aChaturvedi, Rini1 aMirdha, Bijay, R.1 aRahi, Manju1 aSharma, Amit1 aShanmugam, Dhanasekaran uhttps://library.ncl.res.in/content/targeted-genomic-surveillance-unveils-genetic-variations-linked-regional-malaria-drug