02464nas a2200301   4500008004100000022001400041245009900055210006900154260000800223300000900231490000700240520142600247100002601673700002701699700002201726700002301748700002601771700002101797700002701818700002301845700004101868700002201909700002301931700002301954700002701977700003102004856012702035       2020                        eng d  a2045-232200aPlausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy0 aPlausible diagnostic value of urinary isomeric dimethylarginine   cFEB  a29700 v103 a<p>Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans' Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158-0.491] and MAC [OR 0.146; 95% CI: 0.071-0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians.</p>
1 aParmar, Dharmeshkumar1 aBhattacharya, Nivedita1 aKannan, Shanthini1 aVadivel, Sangeetha1 aPandey, Gautam, Kumar1 aGhanate, Avinash1 aRagi, Nagarjuna, Chary1 aPrabu, Paramasivam1 aPramodkumar, Thyparambil, Aravindaks1 aManickam, Nagaraj1 aMohan, Viswanathan1 aSripadi, Prabhakar1 aKuppan, Gokulakrishnan1 aPanchagnula, Venkateswarlu  uhttps://library.ncl.res.in/content/plausible-diagnostic-value-urinary-isomeric-dimethylarginine-ratio-diabetic-nephropathy01253nas a2200361   4500008004100000022001400041245014600055210006900201260000800270300001400278490000700292653002300299653001800322653001400340653001500354653003000369100001800399700004000417700002000457700001700477700002600494700002300520700002200543700002100565700002400586700002600610700003200636700002300668700001900691700003100710700002700741856012300768       2024                        eng d  a0939-475300aCirculatory levels of lysophosphatidylcholine species in obese adolescents: Findings from cross-sectional and prospective lipidomics analyses0 aCirculatory levels of lysophosphatidylcholine species in obese a  cJUL  a1807-18160 v3410aAdolescent obesity10aAsian Indians10abiomarker10aLipidomics10aLysophosphatidyl- choline1 aSharma, Sapna1 aSubrahmanyam, Yalamanchili, Venkata1 aRanjani, Harish1 aSidra, Sidra1 aParmar, Dharmeshkumar1 aVadivel, Sangeetha1 aKannan, Shanthini1 aGrallert, Harald1 aUsharani, Dandamudi1 aAnjana, Ranjit, Mohan1 aBalasubramanyam, Muthuswamy1 aMohan, Viswanathan1 aJerzy, Adamski1 aPanchagnula, Venkateswarlu1 aGokulakrishnan, Kuppan  uhttps://library.ncl.res.in/content/circulatory-levels-lysophosphatidylcholine-species-obese-adolescents-findings-cross