01355nas a2200169 4500008004100000022001400041245011500055210006900170260000900239300001400248490000700262520071800269100002300987700002301010700002101033856013101054 2020 eng d a1359-734500aGold and hypervalent iodine(iii): liaisons over a decade for electrophilic functional group transfer reactions0 aGold and hypervalent iodineiii liaisons over a decade for electr cMAR  a2677-26900 v563 a

Over the last two decades, hypervalent iodine(iii) reagents have evolved from being `bonding curiosities' to mainstream reagents in organic synthesis, in particular, electrophilic functional group transfer reactions. In this context, gold catalysts have not only emerged as a unique toolbox to facilitate such reactions (especially alkynylations) but also opened new possibilities with their different modes of reactivities for other functional group transfer reactions (acetoxylations and arylations). This feature article critically summarizes hitherto all such Au-catalyzed electrophilic functional group transfer reactions with hypervalent iodine(iii) reagents, emphasizing their mechanistic aspects.

1 aBanerjee, Somsuvra1 aBhoyare, Vivek, W.1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/gold-and-hypervalent-iodineiii-liaisons-over-decade-electrophilic-functional-group-transfer01336nas a2200181 4500008004100000022001400041245008300055210006900138260000800207300001400215490000800229520072000237100002600957700002300983700002001006700002101026856010701047 2022 eng d a0002-786300aEnantioselective Au(I)/Au(III) redox catalysis enabled by chiral (P,N)-ligands0 aEnantioselective AuIAuIII redox catalysis enabled by chiral PNli cAPR a7089-70950 v1443 a

Presented herein is the first report of enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos). The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C-2-symmetric chiral environment present around nitrogen, imparting a high level of enantioselectivity.

1 aChintawar, Chetan, C.1 aBhoyare, Vivek, W.1 aMane, Manoj, V.1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/enantioselective-auiauiii-redox-catalysis-enabled-chiral-pn-ligands