02271nas a2200265 4500008004100000022001400041245010900055210006900164260000800233300001000241490000700251520135700258653003501615653001701650653001701667653003501684653000901719100002701728700003101755700002101786700002401807700002301831700002501854856012601879 2020 eng d a0268-260500aAnthrone-spirolactam and quinoline hybrid based sensor for selective fluorescent detection of Fe(3+)ions0 aAnthronespirolactam and quinoline hybrid based sensor for select cOCT ae58670 v343 a

The synthesis of a novel, and highly selective Fe(3+)ion sensor based on anthrone-spirolactam and its quinoline hybrid ligand is reported. The designed ligand displayed selective detection of Fe(3+)ions with enhanced fluorescence emission. The complexation of Fe(3+)ion led to a red shift of 32 nm from 420 nm to 452 nm, and a several fold increase in intensity with fluorescent green emission. The complexation (detection) of Fe(3+)ions with ligand resulted in chelation enhanced fluorescence and intramolecular charge transfer through the inhibition of C=N isomerization. This hybrid sensor shows high sensitivity and selectivity, spontaneous response, and works on a wide pH range a minimum detection limit of 6.83 x 10(-8)M. Importantly, the sensor works through the fluorescence turn-on mechanism that overcomes the paramagnetic effect of Fe(3+)ions. The binding mechanism between the ligand and the Fe(3+)ions was established from the Job's plot method, optical studies, Fourier transfor infrared spectroscopy, NMR titration, fluorescence life-time studies, and density functional theory optimization. The sensor displayed excellent results in the quantification of Fe(3+)ions from real water samples. Furthermore, due to its biocompatibility nature, fluorescent spotting of Fe(3+)ions in live cells revealed its bioimaging applications.

10aanthrone-spirolactam-quinoline10aCell imaging10afluorescence10aintramolecular charge transfer10airon1 aDarole, Ratanamala, S.1 aLeslee, Denzil, Britto Chr1 aMukherjee, Anagh1 aGonnade, Rajesh, G.1 aKaruppannan, Sekar1 aSenthilkumar, Beeran uhttps://library.ncl.res.in/content/anthrone-spirolactam-and-quinoline-hybrid-based-sensor-selective-fluorescent-detection02105nas a2200265 4500008004100000022001400041245015200055210006900207260000900276490000800285520115100293653002601444653002201470653001701492653001401509100002701523700002101550700002401571700002501595700002101620700002101641700002101662700002501683856013101708 2023 eng d a0223-523400aSynthesis of novel rhodamine type anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses0 aSynthesis of novel rhodamine type anthrone Spirolactam ASL analo cDEC 0 v2613 a

A series of Rhodamine type Anthrone-Spirolactam (ASL) derivatives Benzylimin-Anthrone-Spirolactam (ASL-1 to ASL-10) and Benzamide-Anthrone-Spirolactam (ASL-11 and ASL-12) were synthesized via a simple condensation reaction between Anthrone Spiro-lactamine (2) and various aromatic aldehyde and acyl chlorides respectively. Since rhodamine-based compounds were reported to have antiviral activity, the ASL derivatives were examined for in vitro antiviral activity against dengue and chikungunya viruses. Among all the analogues, ASL-3, ASL-6, ASL-7, ASL-8, ASL-9 and ASL-10 were the most potent against dengue virus (DENV) and exerted around one log reduction in virus titre under post -treatment conditions. At the same time ASL-3 was effective under cotreatment conditions. Two analogues ASL-6 and ASL-12 exerted anti-chikungunya virus (CHIKV) activity under post -treatment conditions. In silico docking studies revealed that the ASL derivatives interacted with the proteins of DENV and CHIKV. Together, the results suggest the anti-DENV and CHIKV activity of ASL derivatives which may be exploited further for therapeutic purposes.

10aAnthrone Spiro-lactam10aChikungunya virus10adengue virus10aRhodamine1 aDarole, Ratanamala, S.1 aBagad, Pooja, K.1 aGonnade, Rajesh, G.1 aAlagarasu, Kalichamy1 aPunekar, Madhura1 aShukla, Shridhar1 aParashar, Deepti1 aSenthilkumar, Beeran uhttps://library.ncl.res.in/content/synthesis-novel-rhodamine-type-anthrone-spiro-lactam-asl-analogues-and-evaluation-antiviral01776nas a2200217 4500008004100000022001400041245017200055210007000227260000900297300001400306490000700320520092900327100002701256700003301283700002101316700002401337700001801361700001701379700002501396856013701421 2024 eng d a1477-052000aBrønsted acid- and Ni(ii)-catalyzed C-H oxidation/rearrangement of cyclotriveratrylenes (CTVs) to cyclic and acyclic quinones as potential anti-cancer agents0 aBrønsted acid and Nisciisccatalyzed CH oxidationrearrangement of cJAN  a1038-10460 v223 a

This paper describes a simple and practical protocol for the direct synthesis of acyclic and cyclic quinone derivatives via an acid-promoted nickel(ii)-catalyzed inner rim C-H oxidation of cyclotriveratrylene (CTV) and its analogues. The cyclic quinone derivatives resulted from trimethoxy-cyclotriveratrylene (TCTV) through C-C bond formation via intramolecular ipso substitution followed by subsequent anionic rearrangement containing stereo-vicinal quaternary centers. The DFT calculations strongly support the experimental findings and reveal the role of Bronsted acids in the C-H bond activation of CTV. All the newly synthesized compounds were screened for their in vitro anti-cancer activity using colorimetric SRB assay analysis. Among them, compounds 3a, 3d, 3h, 4a, 4b, 4c and 4e exhibited moderate anticancer activity against A549, HCT-116, PC-3, MDA-MB-231, HEK-293 and SW620 human cancer cell lines.

1 aDarole, Ratanamala, S.1 aChoudhary, Shailendra, Singh1 aSharma, Himanshu1 aMali, Bhupendra, P.1 aGopu, Booblan1 aVanka, Kumar1 aSenthilkumar, Beeran uhttps://library.ncl.res.in/content/br%C3%B8nsted-acid-and-niii-catalyzed-c-h-oxidationrearrangement-cyclotriveratrylenes-ctvs-cyclic01357nas a2200181 4500008004100000022001400041245011100055210006900166260000800235300001400243490000700257520069200264100002100956700002700977700001801004700002501022856012801047 2024 eng d a0022-326300aHighly selective C-N and C-S dual functionalization of 1,3-dicarbonyl derivatives using TBHP as an oxidant0 aHighly selective CN and CS dual functionalization of 13dicarbony cJUN a9371-93800 v893 a

A direct electrosynthesis/photocatalyst-free, atom-economical, and efficient method for the selective synthesis of (E)-3-amino-2-thiocyanato-alpha,beta-unsaturated carbonyl compounds is described through a given protocol. The present approach features the use of inexpensive ammonium thiocyanate to achieve dual functionalization of 1,3-dicarbonyl compounds using TBHP as an oxidant, providing a rapid and practical route to the selective formation of both C-N and C-S bonds via a radical process. This method offers a broad substrate scope with excellent yield and allows for further exploration of the products to construct heterocyclic compounds and other functionalities.

1 aBagad, Pooja, K.1 aDarole, Ratanamala, S.1 aKrishna, Rama1 aSenthilkumar, Beeran uhttps://library.ncl.res.in/content/highly-selective-c-n-and-c-s-dual-functionalization-13-dicarbonyl-derivatives-using-tbhp01218nas a2200169 4500008004100000245011200041210006900153260000900222300001600231490000700247520054900254100003300803700002700836700002600863700002500889856013400914 2025 eng d00aBase mediated approach for the synthesis of deoxybenzoins using γ-aryl-β-ketoesters and benzoyl chlorides0 aBase mediated approach for the synthesis of deoxybenzoins using  cSEP  a32424-324300 v153 a

This study introduces a one-pot, transition metal-free strategy for synthesizing deoxybenzoins, overcoming the challenges of conventional methods. The reaction involves dual acylation of gamma-aryl beta-keto esters using K2CO3 in dioxane at 90 degrees C, followed by a concerted transformation to form deoxybenzoin. The protocol operates under mild conditions, tolerates a broad range of substrates, and produces minimal by-products, making it a practical, scalable alternative for accessing pharmaceutically relevant deoxybenzoins.

1 aChoudhary, Shailendra, Singh1 aDarole, Ratanamala, S.1 aKrishna, Gamidi, Rama1 aSenthilkumar, Beeran uhttps://library.ncl.res.in/content/base-mediated-approach-synthesis-deoxybenzoins-using-%CE%B3-aryl-%CE%B2-ketoesters-and-benzoyl