01489nas a2200217   4500008004100000022001400041245013800055210006900193260005700262300001200319490000700331520063900338653001800977653002000995653001901015653003401034653002701068100002401095700002501119856012701144       2012                        eng d  a0175-757100aEffect of the A30P mutation on the structural dynamics of micelle-bound alpha synuclein released in water: a molecular dynamics study0 aEffect of the A30P mutation on the structural dynamics of micell  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcMAY  a483-4890 v413 a<p>Atomistic molecular dynamics simulation has been used to probe the effect of the A30P mutation on the structural dynamics of micelle-bound, helical alpha Synuclein when released in an aqueous environment. On the timescales simulated, the effect of the mutation on the secondary structure is restricted to local changes close to the mutation site in the N-terminal helical domain. The changes are transient, and all residues except Lys23 recover their initial structure. The local behavior due to the mutation gives rise to a global difference in the A30P mutant in the form of a permanent kink in the N-terminal helical domain.</p>10aA30P mutation10aAlpha synuclein10aKink formation10amolecular dynamics simulation10aStructural persistence1 aChatterjee, Prathit1 aSengupta, Neelanjana  uhttps://library.ncl.res.in/content/effect-a30p-mutation-structural-dynamics-micelle-bound-alpha-synuclein-released-water-0