01862nas a2200169   4500008004100000022001400041245009400055210006900149260000800218300001600226490000600242520125300248100002201501700001901523700003001542856012001572       2020                        eng d  a2470-134300aDevelopment of a smart scaffold for sequential cancer chemotherapy and tissue engineering0 aDevelopment of a smart scaffold for sequential cancer chemothera  cAUG  a20724-207330 v53 a<p>The fabrication of a dual-functional drug-containing porous polymeric scaffold by layer-by-layer surface modification involving citrate-stabilized gold nanoparticles and cisplatin molecules is being reported. These scaffolds were characterized by electron microscopy and X-ray photoelectron spectroscopy. The capability of the scaffolds to release hydrated cisplatin in a slow and sustained manner over two days is established. Most importantly, the scaffolds turn nontoxic and cell-friendly after drug release, thus allowing the noncancerous fibroblast cells to adhere and proliferate (from 5000 cells to 16,000 cells in 6 days), becoming a potential solution toward an effective drug-carrying scaffold for volume-filling applications. The scaffold-mediated cancer cell killing and fibroblast cell proliferation were confirmed by fluorescence microscopy imaging, flow cytometry, and cell proliferation assays. We surmise that such a dual-purpose (drug-delivery and volume-filler) scaffold could help avoid the multiple surgical interventions needed for tumor surgery and cosmetic corrections. To the best of our knowledge, this is the first example of scaffolds with such a dual functionality which gets manifested in a sequential manner.</p>
1 aSengupta, Poulomi1 aAgrawal, Vinay1 aPrasad, Bhagavatula L. V.  uhttps://library.ncl.res.in/content/development-smart-scaffold-sequential-cancer-chemotherapy-and-tissue-engineering