01365nas a2200265 4500008004100000022001400041245008700055210006900142260010600211300001400317490000700331520039500338653002500733653002500758653001500783653002100798653002000819100003100839700002700870700002200897700002200919700002200941700002100963856011500984 2015 eng d a0040-403900aFirst synthesis of nitrosporeusines, alkaloids with multiple biological activities0 aFirst synthesis of nitrosporeusines alkaloids with multiple biol aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR a1252-12540 v563 a

Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product, maleimycin, in optically pure form using a gram-scale enzymatic resolution method. (C) 2015 Elsevier Ltd. All rights reserved.

10aEnzymatic resolution10aInfluenza H1N1 virus10aMaleimycin10aMichael reaction10aNitrosporeusine1 aPhilkhana, Satish, Chandra1 aJachak, Gorakhnath, R.1 aGunjal, Vidya, B.1 aDhage, Nagsen, M.1 aBansode, Ajay, H.1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/first-synthesis-nitrosporeusines-alkaloids-multiple-biological-activities-001828nas a2200145 4500008004100000245011600041210006900157260000800226520122000234100002601454700002201480700002401502700002601526856013001552 2019 eng d00aAgNO3-Catalysed intramolecular cyclization: access to functionalized cyclopentanones and spiro-cyclopentanones 0 aAgNO3Catalysed intramolecular cyclization access to functionaliz cAUG3 a

An efficient AgNO3-catalysed method has been developed for the synthesis of functionalized cyclopentanones and spiro-cyclopentanones through intramolecular cyclization between ynones and cyanoacrylate/aryl/alkylidene malononitrile using DBU as a base. Easy availability of starting materials and mild reaction conditions makes this protocol more feasible over previously reported methods. The functionalized cyclopentanones and spiro-cyclopentanones were synthesized in good to excellent yields with a broad substrate scope.

1 aBhoite, Shubhangi, P.1 aBansode, Ajay, H.1 aBurate, Pralhad, A.1 aSuryayanshi, Gurunath uhttps://library.ncl.res.in/content/agno3-catalysed-intramolecular-cyclization-access-functionalized-cyclopentanones-and-spiro01073nas a2200157 4500008004100000022001400041245012600055210006900181260000800250300001400258490000600272520045900278100002200737700002600759856013000785 2019 eng d a2470-134300aIodine-mediated oxidative rearrangement of alpha,beta-unsaturated diaryl ketones: a facile access to 1,2-diaryl diketones0 aIodinemediated oxidative rearrangement of alphabetaunsaturated d cJUN a9636-96440 v43 a

A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing alpha, beta-unsaturated diaryl ketones and I-2/TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C-C bond cleavage. A simple and high-yielding protocol was developed for the synthesis of a wide range of 1,2-diaryl diketones, which are the backbone for a variety of medicinally important molecules.

1 aBansode, Ajay, H.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/iodine-mediated-oxidative-rearrangement-alphabeta-unsaturated-diaryl-ketones-facile-access01138nas a2200193 4500008004100000022001400041245009600055210006900151260000800220300001400228490000700242520044500249100002800694700002700722700002100749700002200770700002600792856012600818 2021 eng d a1144-054600aHypervalent iodine(iii) induced oxidative olefination of benzylamines using Wittig reagents0 aHypervalent iodineiii induced oxidative olefination of benzylami cMAY a8806-88130 v453 a

We have developed hypervalent iodine(iii) induced oxidative olefination of primary and secondary benzylamines using 2C-Wittig reagents, which provides easy access to alpha,beta-unsaturated esters. Mild reaction conditions, good to excellent yields with high (E) selectivity, and a broad substrate scope are the key features of this reaction. We have successfully carried out the gram-scale synthesis of alpha,beta-unsaturated esters.

1 aRamavath, Vijayalakshmi1 aRupanawar, Bapurao, D.1 aMore, Satish, G.1 aBansode, Ajay, H.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/hypervalent-iodineiii-induced-oxidative-olefination-benzylamines-using-wittig-reagents01421nas a2200253 4500008004100000022001400041245017800055210006900233260000900302300001400311490000800325520050500333653000600838653000600844653003500850653003000885653002600915653002000941653001400961653001900975100002200994700002601016856012501042 2021 eng d a1615-415000aVisible-light-induced controlled oxidation of N-substituted 1,2,3,4-tetrahydroisoquinolines for the synthesis of 3,4-dihydroisoquinolin-1(2h)-ones and isoquinolin-1(2H)-ones0 aVisiblelightinduced controlled oxidation of Nsubstituted 1234tet cMAR  a1390-14000 v3633 a

A visible light-rose bengal-TBHP mediated, controlled oxidation of N-substituted 1,2,3,4-tetrahydroisoquinolines is developed for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones and isoquinolin-1(2H)-ones. The present method feature's a broad substrate scope, good functional group tolerances, and the products were prepared in good to excellent yields. The developed methodology further demonstrated in the synthesis of isoindolo[2,1-b] isoquinolin-5(7H)-one (topoisomerase-I inhibitor).

10a210a310a4-Dihydroisoquinolin-1(2H)-one10a4-tetrahydroisoquinolines10aIsoquinolin-1(2H)-one10aN-substituted 110aOxidation10aPhotocatalysis1 aBansode, Ajay, H.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/visible-light-induced-controlled-oxidation-n-substituted-1234-tetrahydroisoquinolines01434nas a2200229 4500008004100000022001400041245011900055210006900174260000800243300001200251490000700263520064000270653002000910653001100930653002300941653001600964653001400980100002700994700002201021700002601043856013501069 2025 eng d a0936-521400aHypervalent-iodine-mediated base-free oxidative olefination of benzylic amines to access α,β-unsaturated ketones0 aHypervalentiodinemediated basefree oxidative olefination of benz cAUG a556-5600 v363 a

We report a one-pot base-free protocol for the oxidative olefination of benzylic amines promoted by a hypervalent iodine reagent for the synthesis of alpha,beta-unsaturated ketones. Mechanistically, (diacetoxyiodo)benzene oxidizes the benzylic amine to the corresponding imine, which, on reaction with a phenacyl(triphenyl)phosphonium bromide salt and an in situ generated acetoxy anion leads to an alpha,beta-unsaturated ketone. A wide range of alpha,beta-unsaturated ketones were easily accessed through direct oxidative olefination of substituted benzylic amines in good to excellent yields and with high E -selectivity.

10abenzylic amines10aenones10ahypervalent iodine10aolefination10aOxidation1 aRupanawar, Bapurao, D.1 aBansode, Ajay, H.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/hypervalent-iodine-mediated-base-free-oxidative-olefination-benzylic-amines-access-%CE%B1%CE%B2