01295nas a2200181   4500008004100000022001400041245009000055210006900145260000900214300001600223490000600239520068300245100002800928700001600956700002400972700000500996856011201001       2020                        eng d  a2470-134300aTotal synthesis of (+)-petromyroxol, (-)-iso-petromyroxol, and possible diastereomers0 aTotal synthesis of petromyroxol isopetromyroxol and possible dia  cOCT   a25334-253480 v53 a<p>The total synthesis of (+)-petromyroxol (1) and its seven diastereomers including the ()-tso-petromyroxol (2) is described. The employed strategy involves the use of easily available CS-epimeric epoxides 5 and 5' and nonselective anomeric C1-allylation, proceeding with or without inversion at C2 thereby giving the possibility of synthesizing all possible diastereomers. Extensive two-dimensional (2D) NMR analyses of all eight diastereomers have been carried out to assign the chemical shifts of the central carbons land the corresponding attached hydrogens and to learn how the C/H-chemical shifts of the tetrahydrofuran ring were influenced by the adjacent centers.</p>
1 aMullapudi, Venkannababu1 aAhmad, Iram1 aSenapati, Sibadatta1 a  uhttps://library.ncl.res.in/content/total-synthesis-petromyroxol-iso-petromyroxol-and-possible-diastereomers01499nas a2200241   4500008004100000022001400041245015600055210006900211260000800280520054000288653002900828653003200857653002700889653002300916653006100939100002401000700002401024700002001048700001601068700002001084700002401104856012901128       2021                        eng d  a0039-788100aUnified approach for the total aynthesis of Bis-THF C-15 acetogenins: a chloroenyne from laurencia majuscula, laurendecumenyne B and laurefurenynes A/B0 aUnified approach for the total aynthesis of BisTHF C15 acetogeni  cMAY3 a<p>A highly diastereoselective total synthesis of several bis-THF C-15 acetogenin natural products, chloroenyne from Laurencia majuscula, laurendecumenyne B, and laurefurenyries A/B, is reported. Additionally the synthesis of an advanced intermediate reported in the earlier total synthesis of (E/Z)-elatenynes (formal synthesis) is described. The salient features in the synthesis include epoxide opening, Birch reduction, Sharpless asymmetric dihydroxylation-cycloetherification, S(N)2 halogenation, and a relay cross metathesis.</p>10abis-THF C-15 acetogenins10acarbohydrate building block10arelay-cross-metathesis10aS(N)2 halogenation10aSharpless asymmetric dihydroxylation-cycloetherification1 aSenapati, Sibadatta1 aUnmesh, Nivedya, A.1 aShet, Manoj, N.1 aAhmad, Iram1 aAjikumar, Nandu1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/unified-approach-total-aynthesis-bis-thf-c-15-acetogenins-chloroenyne-laurencia-majuscula01538nas a2200265   4500008004100000022001400041245015600055210006900211260000900280300001400289490000700303520053300310653002900843653003200872653002700904653002300931653006100954100002401015700002401039700002001063700001601083700002001099700002401119856012901143       2021                        eng d  a0039-788100aUnified approach for the total synthesis of Bis-THF C-15 acetogenins: a chloroenyne from laurencia majuscula, laurendecumenyne B and laurefurenynes A/B0 aUnified approach for the total synthesis of BisTHF C15 acetogeni  cAUG   a2903-29100 v533 aA highly diastereoselective total synthesis of several bis-THF C-15 acetogenin natural products, chloroenyne from Laurencia majuscula, laurendecumenyne B, and laurefurenyries A/B, is reported. Additionally the synthesis of an advanced intermediate reported in the earlier total synthesis of (E/Z)-elatenynes (formal synthesis) is described. The salient features in the synthesis include epoxide opening, Birch reduction, Sharpless asymmetric dihydroxylation-cycloetherification, S(N)2 halogenation, and a relay cross metathesis.10abis-THF C-15 acetogenins10acarbohydrate building block10arelay-cross-metathesis10aS(N)2 halogenation10aSharpless asymmetric dihydroxylation-cycloetherification1 aSenapati, Sibadatta1 aUnmesh, Nivedya, A.1 aShet, Manoj, N.1 aAhmad, Iram1 aAjikumar, Nandu1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/unified-approach-total-synthesis-bis-thf-c-15-acetogenins-chloroenyne-laurencia-majuscula