01299nas a2200169   4500008004100000022001400041245011800055210006900173260000900242300001400251490000700265520065200272100003300924700002100957700002100978856013000999       2020                        eng d  a1477-052000aFeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities0 aFeCl3catalyzed oxidative decarboxylation of arylheteroaryl aceti  cNOV   a8459-84660 v183 a<p>There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.</p>
1 aGangadurai, Chinnakuzhanthai1 aIlla, Giri, Teja1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/fecl3-catalyzed-oxidative-decarboxylation-arylheteroaryl-acetic-acids-preparation-selected