02551nas a2200181   4500008004100000245008300041210006900124260000900193300001600202490000700218520191800225100002302143700001802166700002102184700002602205700002902231856010902260       2020                        eng d00aBlends of neem oil based polyesteramide as nanofiber mats to control Culicidae0 aBlends of neem oil based polyesteramide as nanofiber mats to con  cNOV   a42827-428370 v103 a<p>Mosquitoes act as vectors for several disease-causing microorganisms and pose a threat to mankind by transmitting various diseases. There are different conventional methods to repel or kill these mosquitoes for avoiding susceptibility against infections. However, to overcome the difficulties with conventional methods, new advanced materials are being studied. For the first time, we report developing a nanofiber mat with a controlled release of insecticide to repel or detain the mosquitoes. Briefly, various blend compositions were prepared by manipulating the ratio of neem oil-based polyesteramide (PEA) and polycaprolactone (PCL) immobilized with insecticide, transfluthrin (Tf). The blend solutions were electrospun to get non-woven nanofiber mats, and these nanomaterials were characterized by various spectroscopic techniques to understand their physicochemical properties. The surface morphology was analyzed using environmental scanning electron microscopy (E-SEM), and the diameter of the nanofibers was in the range of 200 to 450 nm. Further, thermal and mechanical properties were evaluated to understand the stability of nanofiber mats. In vitro drug release studies of nanofiber mat PPT-1335 showed controlled and sustained release of Tf, with similar to 35% of Tf released in 24 h. However, a film of the same composition (PPT-1335) showed similar to 5% of Tf release within 24 h. Moreover, in vivo bio-efficacy studies suggested the mortality of mosquitoes was about 50% with PP-133, which was further increased to 100% within 12 h in the presence of Tf (PPT-1335). However, 60% mortality of mosquitoes was observed with the film of PPT-1335. Hence, the nanofiber mat showed better efficacy against mosquitoes as compared to the film of the same composition. The degradation studies under various conditions revealed biocompatibility of the developed nanofiber mats with the ecosystem.</p>
1 aKonchada, Sravanya1 aKilli, Naresh1 aSayyad, Shahebaz1 aGathalkar, Ganesh, B.1 aGundloori, Rathna, V. N.  uhttps://library.ncl.res.in/content/blends-neem-oil-based-polyesteramide-nanofiber-mats-control-culicidae02121nas a2200277   4500008004100000022001400041245011800055210006900173260000900242300001600251490000600267520114500273653002201418653002901440653002001469653004901489653002201538100002101560700002101581700001801602700002301620700001701643700003401660700002301694856012601717       2021                        eng d  a2168-048500aOne-pot bioconversion of tomato waste into poly-gamma-glutamic acid (gamma-PGA) biopolymer by a novel biocatalyst0 aOnepot bioconversion of tomato waste into polygammaglutamic acid  cNOV   a14330-143340 v93 aLandfilling of rotten tomatoes can lead to environmental instability and a huge economic loss to the producers. This letter reports an effective valorization of tomato waste into a promising biopolymer, i.e., poly-gamma-glutamic acid (gamma-PGA) by a novel biocatalyst Bacillus paralicheniformis NCIM 5769. The gamma-PGA is one of the most expensive biopolymers with multifarious applications in wound healing, drug delivery, and regenerative medicine fields. However, its adoption into various applications is finite due to its exorbitant production cost. Herein, rotten tomatoes (without additional nutrient supplementation) served as the chassis for the fermentative production of 40 g/L of highly pure gamma-PGA within 48 h at ambient temperature. Further, NMR, DSC, and TGA confirmed the purity of synthesized gamma-PGA identical to standard gamma-PGA. This process has potential in the commercialization of.-PGA by significantly reducing the production cost, followed by the effective utilization of tomato waste leading to United Nations Sustainable Development Goal 12 (i.e., ensure sustainable consumption and production patterns).10aCommercialization10aPoly-gamma-glutamic acid10aRotten tomatoes10aUnited Nations Sustainable Development Goals10aWaste utilization1 aNair, Pranav, G.1 aJoseph, Emmanuel1 aKilli, Naresh1 aKonchada, Sravanya1 aNisal, Anuya1 aGundloori, Rathna, Venkata Na1 aDharne, Mahesh, S.  uhttps://library.ncl.res.in/content/one-pot-bioconversion-tomato-waste-poly-gamma-glutamic-acid-gamma-pga-biopolymer-novel