01569nas a2200253   4500008004100000022001400041245019000055210006900245260010600314300001400420490000700434520053900441653002000980653002501000653002401025653001801049653001201067100001701079700003201096700002201128700002601150700002201176856011701198       2010                        eng d  a0040-403900aFacile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol via proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination of aldehyde0 aFacile enantioselective synthesis of SN5chlorothiophene2sulfonyl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6565-65670 v513 a<p>A high-yielding enantioselective synthesis of the bioactive (S)-N-(5-chlorothiophene-2-sulfonyl)beta,beta-diethylalaninol (1), a Notch-1-sparing gamma-secretase inhibitor metabolite (with EC50 = 28 nM) effective in reduction of All production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed alpha-aminooxylation and alpha-amination of aldehyde: the latter contributing an overall yield of 45.2% and 98% ee. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aalpha-Amination10aalpha-Aminooxylation10aAlzheimer's disease10aAmino alcohol10aProline1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aChavan, Vilas, B.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/facile-enantioselective-synthesis-s-n-5-chlorothiophene-2-sulfonyl-betabeta-001314nas a2200217   4500008004100000022001400041245008400055210006900139260010600208300001400314490000700328520047300335653002500808653004000833653001400873653002800887653002000915100002100935700002600956856011400982       2015                        eng d  a0040-403900aEfficient organocatalytic route for asymmetric total synthesis of stagonolide F0 aEfficient organocatalytic route for asymmetric total synthesis o  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6207-62090 v563 a<p>A stereoselective total synthesis of Stagonolide F (98% ee) is described employing asymmetric alpha-aminooxylation, Jorgensen's asymmetric epoxidation, Brown asymmetric allylation, Steglich esterification and ring closing metathesis as key steps. The use of organocatalytic alpha-aminooxylation and Jorgensen's asymmetric epoxidation of aldehydes for the introduction of chirality makes this approach more attractive. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aalpha-Aminooxylation10aJorgensens's asymmetric epoxidation10aMacrolide10aRing-closing metathesis10aTotal synthesis1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/efficient-organocatalytic-route-asymmetric-total-synthesis-stagonolide-f-0