01323nas a2200157   4500008004100000022001400041245015700055210006900212260007100281300001400352490000700366520061500373100002100988700002601009856013001035       2016                        eng d  a1523-706000aFluoride-assisted synthesis of 1,4,5,6-tetrahydropyridazines via [4+2] cyclodimerization of in situ-generated azoalkenes followed by a C-N bond cleavage0 aFluorideassisted synthesis of 1456tetrahydropyridazines via 42 c  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG  a3968-39710 v183 a<p>An unexpected CsF-assisted C-N bond cleavage was exploited to synthesize highly functionalized and biologically important 1,4,5,6-tetralrydropyridazine derivatives from alpha-halo N-acylhydrazohes in excellent yields. The extrusion of nitrogen and the [4 + 2] cycloaddition between in situ-generated azoalkenes is a key reaction in the process. The identified methodology is suitable for synthesizing a wide variety of analogues of tetrahydropyridazines, which are prevalent in many medicinally important small molecules. The reaction conditions are mild, high-yielding, and amenable for the gram scale.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/fluoride-assisted-synthesis-1456-tetrahydropyridazines-42-cyclodimerization-situ-generated01316nas a2200157   4500008004100000022001400041245016700055210006900222260010600291300001200397490000700409520056900416100002100985700002601006856012601032       2016                        eng d  a0957-416600aFormal synthesis of pinolide via L-proline-catalyzed sequential alpha-aminooxylation, horner-wadsworth-emmons olefination and sharpless asymmetric dihydroxylation0 aFormal synthesis of pinolide via Lprolinecatalyzed sequential al  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a142-1470 v273 a<p>A convergent, formal enantioselective synthesis of pinolide, a new nonenolide, has been achieved with high enantiomeric purity (99% ee) starting from readily available raw materials. The main highlight of the synthetic strategy is the application of L-proline catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination of an aldehyde, Sharpless asymmetric dihydroxylation and Steglich esterification as the key steps for the construction of a key chiral intermediate of the target molecule. (C) 2016 Elsevier Ltd. All rights reserved.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/formal-synthesis-pinolide-l-proline-catalyzed-sequential-alpha-aminooxylation-horner-0