01239nas a2200181   4500008004100000022001400041245008700055210006900142260010600211300001400317490000700331520052600338100002100864700001700885700002600902700002200928856010700950       2012                        eng d  a0957-416600aAsymmetric synthesis of (+)-stagonolide C and (-)-aspinolide A via organocatalysis0 aAsymmetric synthesis of stagonolide C and aspinolide A via organ  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a1534-15410 v233 a<p>A new enantioselective synthesis of two important fungal metabolites, (+)-stagonolide C and (-)-aspinolide A, has been described from readily available raw materials. Praline catalyzed asymmetric alpha-aminooxylation and Jorgensen's epoxidation of aldehydes are the key reactions employed in the introduction of chirality. The formation of the 10-membered lactone core structure was finally accomplished via Steglich esterification and ring closing metathesis reactions. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aShelke, Anil, M.1 aRawat, Varun1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/asymmetric-synthesis-stagonolide-c-and-aspinolide-organocatalysis-001263nas a2200157   4500008004100000022001400041245021300055210006900268260011000337300001400447490000700461520045900468100002100927700002600948856013100974       2015                        eng d  a1477-052000aEfficient one pot regioselective synthesis of a 3,3 `-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones0 aEfficient one pot regioselective synthesis of a 33 spirophosphon  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a8669-86750 v133 a<p>A one pot, highly regioselective synthesis of racemic 3,3'-spiro-phosphonylpyrazole-oxindole by 1,3-dipolar cycloaddition of an in situ generated anion of dialkyl 1-diazomethylphosphonate from the Bestmann-Ohira reagent (BOR) &amp; methyleneindolinones has been developed. The synthesis affords the highly functionalized pyrazole scaffolds in good yields with excellent regioselectivity under mild reaction conditions within a short reaction time.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/efficient-one-pot-regioselective-synthesis-33-spiro-phosphonylpyrazole-oxindole-framework-001314nas a2200217   4500008004100000022001400041245008400055210006900139260010600208300001400314490000700328520047300335653002500808653004000833653001400873653002800887653002000915100002100935700002600956856011400982       2015                        eng d  a0040-403900aEfficient organocatalytic route for asymmetric total synthesis of stagonolide F0 aEfficient organocatalytic route for asymmetric total synthesis o  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6207-62090 v563 a<p>A stereoselective total synthesis of Stagonolide F (98% ee) is described employing asymmetric alpha-aminooxylation, Jorgensen's asymmetric epoxidation, Brown asymmetric allylation, Steglich esterification and ring closing metathesis as key steps. The use of organocatalytic alpha-aminooxylation and Jorgensen's asymmetric epoxidation of aldehydes for the introduction of chirality makes this approach more attractive. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aalpha-Aminooxylation10aJorgensens's asymmetric epoxidation10aMacrolide10aRing-closing metathesis10aTotal synthesis1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/efficient-organocatalytic-route-asymmetric-total-synthesis-stagonolide-f-001323nas a2200157   4500008004100000022001400041245015700055210006900212260007100281300001400352490000700366520061500373100002100988700002601009856013001035       2016                        eng d  a1523-706000aFluoride-assisted synthesis of 1,4,5,6-tetrahydropyridazines via [4+2] cyclodimerization of in situ-generated azoalkenes followed by a C-N bond cleavage0 aFluorideassisted synthesis of 1456tetrahydropyridazines via 42 c  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG  a3968-39710 v183 a<p>An unexpected CsF-assisted C-N bond cleavage was exploited to synthesize highly functionalized and biologically important 1,4,5,6-tetralrydropyridazine derivatives from alpha-halo N-acylhydrazohes in excellent yields. The extrusion of nitrogen and the [4 + 2] cycloaddition between in situ-generated azoalkenes is a key reaction in the process. The identified methodology is suitable for synthesizing a wide variety of analogues of tetrahydropyridazines, which are prevalent in many medicinally important small molecules. The reaction conditions are mild, high-yielding, and amenable for the gram scale.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/fluoride-assisted-synthesis-1456-tetrahydropyridazines-42-cyclodimerization-situ-generated01316nas a2200157   4500008004100000022001400041245016700055210006900222260010600291300001200397490000700409520056900416100002100985700002601006856012601032       2016                        eng d  a0957-416600aFormal synthesis of pinolide via L-proline-catalyzed sequential alpha-aminooxylation, horner-wadsworth-emmons olefination and sharpless asymmetric dihydroxylation0 aFormal synthesis of pinolide via Lprolinecatalyzed sequential al  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a142-1470 v273 a<p>A convergent, formal enantioselective synthesis of pinolide, a new nonenolide, has been achieved with high enantiomeric purity (99% ee) starting from readily available raw materials. The main highlight of the synthetic strategy is the application of L-proline catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination of an aldehyde, Sharpless asymmetric dihydroxylation and Steglich esterification as the key steps for the construction of a key chiral intermediate of the target molecule. (C) 2016 Elsevier Ltd. All rights reserved.</p>1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/formal-synthesis-pinolide-l-proline-catalyzed-sequential-alpha-aminooxylation-horner-001075nas a2200193   4500008004100000245009800041210006900139260000800208300001400216490000700230520037400237100002400611700002400635700002400659700002600683700002100709700002600730856012500756       2017                        eng d00aEfficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework0 aEfficient SnIIcatalyzed onepot synthesis of a 3substituted azeti  cMAR  a2385-23910 v153 aA novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C-N cyclization reaction.1 aChavan, Santosh, S.1 aSupekar, Mrudul, V.1 aBurate, Pralhad, A.1 aRupanwar, Bapurao, D.1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/efficient-snii-catalyzed-one-pot-synthesis-3-substituted-azetidine-24-dione-framework01186nas a2200181   4500008004100000245013400041210007000175260000800245300001300253490000600266520048100272100002400753700002700777700002200804700002100826700002600847856013100873       2018                        eng d00aMetal-free annulation of β-acylamino ketones: facile access to spirooxazolines and oxazolines via oxidative C–O bond formation0 aMetalfree annulation of βacylamino ketones facile access to spir  cOCT  a544-548 0 v53 aA metal-free annulation reaction of β-acylamino ketone derivatives has been reported for the synthesis of a group of functionalized spirooxazolines and oxazolines in good to excellent yields. The reaction proceeds via phenyliodine(III) diacetate (PIDA)-mediated oxidative C–O bond formation in the presence of BF3–OEt2. The mild reaction conditions, broad substrate scope, simple execution and synthetic potential of the products make this novel protocol very attractive.1 aChavan, Santosh, S.1 aRupanawar, Bapurao, D.1 aKamble, Rohit, B.1 aShelke, Anil, M.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/metal-free-annulation-%CE%B2-acylamino-ketones-facile-access-spirooxazolines-and-oxazolines