01072nas a2200229   4500008004100000022001400041245010200055210006900157260011700226300001200343490000700355520021000362653001500572653002400587653001200611100002400623700001800647700001700665700001500682700001400697856013100711       2005                        eng d  a1424-637600aCatalytic transesterification of beta-ketoesters with zeolite H-FER under solvent free conditions0 aCatalytic transesterification of betaketoesters with zeolite HFE  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcMAY  a162-1680 v133 a<p>Zeolite H-FER catalyzes the transesterification of beta-ketoesters with variety of alcohols under solvent-less condition in excellent yields. The catalyst can be reused without any loss of activity.</p>10aferrierite10atransesterification10azeolite1 aChavan, Subhash, P.1 aPasupathy, K.1 aShengule, S.1 aShinde, V.1 aAnand, R.  uhttps://library.ncl.res.in/content/catalytic-transesterification-beta-ketoesters-zeolite-h-fer-under-solvent-free-conditions-001124nas a2200193   4500008004100000022001400041245018200055210006900237260007100306300001400377490000700391520029000398100002400688700002500712700002300737700002300760700002300783856012400806       2005                        eng d  a0022-326300aDiastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5H-imidazo[1,5-c][1, 3]thiazol-5-one : a short and highly efficient synthesis of (+)-biotin0 aDiastereoselective amidoalkylation of 3S7aR6benzyl7hydroxy3pheny  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR  a1901-19030 v703 a<p>A short and highly efficient synthesis of W-biotin in 10 steps with 20% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.</p>1 aChavan, Subhash, P.1 aChittiboyina, A., G.1 aRavindranathan, T.1 aKamat, Subhash, K.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/diastereoselective-amidoalkylation-3s7ar-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5h-101062nas a2200181   4500008004100000022001400041245009000055210006900145260010600214300001200320490000700332520035600339100002400695700001600719700001500735700002300750856010700773       2005                        eng d  a0040-403900aEfficient stereoselective synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine0 aEfficient stereoselective synthesis of 2S4S5R and 2R4R5Sbulgecin  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a439-4410 v463 a<p>A short synthetic route to (-)-and (+)-bulgecinine, the amino acid moiety of the bulgecins was achieved from the readily available nonchiral pool starting material cis-2-butene-1,4-diol in which a Claisen orthoester rearrangement and a Sharpless asymmetric dihydroxylation were used as the key steps. (C) 2004 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aPraveen, C.1 aSharma, P.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/efficient-stereoselective-synthesis-2s4s5r-and-2r4r5s-bulgecinine-001037nas a2200205   4500008004100000022001400041245011800055210006900173260007500242300001400317520023700331653002200568653001200590653002100602653002000623100002400643700001700667700001800684856012900702       2005                        eng d  a0936-521400aFacile regioselective decomposition of tosylhydrazones: an application towards the synthesis of alpha-lipoic acid0 aFacile regioselective decomposition of tosylhydrazones an applic  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcMAY  a1129-11323 a<p>A facile regioselective decomposition of tosylhydrazones using NaOH as a base in refluxing isopropyl alcohol is described. This finding has been Successfully applied towards the synthesis of (&amp;PLUSMN;)-α-lipoic acid (1).</p>10aalpha-lipoic acid10aOlefins10aRegioselectivity10atosylhydrazones1 aChavan, Subhash, P.1 aKale, R., R.1 aPasupathy, K.  uhttps://library.ncl.res.in/content/facile-regioselective-decomposition-tosylhydrazones-application-towards-synthesis-alpha-001061nas a2200241   4500008004100000022001400041245006000055210005500115260010600170300001400276490000700290520023800297653001600535653002400551653002000575100002400595700001600619700002500635700001900660700002500679700002500704856009000729       2005                        eng d  a0040-402000aFirst enantiospecific synthesis of (+)-beta-herbertenol0 aFirst enantiospecific synthesis of betaherbertenol  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR  a3873-38790 v613 a<p>The first enantiospecific synthesis of (+)-beta-herbertenol, from naturally occurring R-(+)-citronellal, employing Taber's diazo decomposition protocol as the key step, is described. (c) 2005 Elsevier Ltd. All rights reserved.</p>10acitronellal10adiazo decomposition10aenantiospecific1 aChavan, Subhash, P.1 aThakkar, M.1 aKharul, Rajendra, K.1 aPathak, A., B.1 aBhosekar, Gaurav, V.1 aBhadbhade, Mohan, M.  uhttps://library.ncl.res.in/content/first-enantiospecific-synthesis-beta-herbertenol-001066nas a2200253   4500008004100000022001400041245008700055210006900142260008600211300001200297490000700309520017200316653001200488653002200500653003200522653001600554653001400570100002400584700002500608700002300633700002300656700001700679856011600696       2005                        eng d  a0039-791100aSimple, concise, stereocontrolled synthesis of (8E,10Z)-pentadecadien-1-ol acetate0 aSimple concise stereocontrolled synthesis of 8E10Zpentadecadien1  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcAUG  a987-9940 v353 a<p>A simple, concise, and stereocontrolled synthesis of (8E, 10Z)-pentadecadien-l -ol acetate involving a Cadiot-Chodkiewicz reaction as the key step is described.</p>10aacetate10aAcrobasis vaccini10aCadiot-Chodkiewicz reaction10adiacetylene10aPheromone1 aChavan, Subhash, P.1 aKharul, Rajendra, K.1 aKamat, Subhash, K.1 aKalkote, Uttam, R.1 aKale, R., R.  uhttps://library.ncl.res.in/content/simple-concise-stereocontrolled-synthesis-8e10z-pentadecadien-1-ol-acetate-001020nas a2200205   4500008004100000022001400041245007600055210006900131260007500200300001400275520027500289653002300564653002200587653001500609653002500624100002400649700001900673700001800692856010400710       2005                        eng d  a0039-788100aSimplistic expedient and practical synthesis of (+/-)-alpha-lipoic acid0 aSimplistic expedient and practical synthesis of alphalipoic acid  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcMAY  a1297-13003 a<p>Synthesis of a-lipoic acid has been achieved by a simple sequence of reactions. The synthesis highlights the use of alpha-chloroesters in a Reformatsky reaction. The intermediate keto acid is an intermediate from which both isomers of lipoic acid can be prepared.</p>10aalpha-chloroesters10aalpha-lipoic acid10aOzonolysis10aReformatsky reaction1 aChavan, Subhash, P.1 aShivsankar, K.1 aPasupathy, K.  uhttps://library.ncl.res.in/content/simplistic-expedient-and-practical-synthesis-alpha-lipoic-acid-001222nas a2200229   4500008004100000022001400041245005200055210004800107260010600155300001400261490000700275520043200282653001100714653001900725653003800744653001900782653002800801653004100829100002400870700001600894856008200910       2005                        eng d  a0040-403900aStereoselective synthesis of (-)-microcarpalide0 aStereoselective synthesis of microcarpalide  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a1939-19410 v463 a<p>A highly convergent and efficient synthesis of (-)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strategy highlights the application of novel hydroxy lactone precursors for the stereoselective synthesis of (-)-microcarpalide. (C) 2005 Elsevier Ltd. All rights reserved.</p>10a4-diol10acis-2-butene-110aClaisen ortho ester rearrangement10amicrocarpalide10aRing-closing metathesis10asharpless asymmetric dihydroxylation1 aChavan, Subhash, P.1 aPraveen, C.  uhttps://library.ncl.res.in/content/stereoselective-synthesis-microcarpalide-000786nas a2200181   4500008004100000245003400041210003000075260011700105300001200222490000900234520017600243653001500419653001700434653004100451100002400492700002400516856006400540       2005                        eng d00aSynthesis of (+)-camptothecin0 aSynthesis of camptothecin  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcJAN  a165-1690 v20053 a<p>A synthesis of optically pure camptothecin was achieved in 4 steps from previously reported aldehyde employing Sharpless asymmetric dihydroxylation as the key step.</p>10aAnticancer10acamptothecin10asharpless asymmetric dihydroxylation1 aChavan, Subhash, P.1 aVenkatraman, M., S.  uhttps://library.ncl.res.in/content/synthesis-camptothecin-001382nas a2200301   4500008004100000022001400041245008300055210006900138260010600207300001400313490000700327520035600334653001100690653001900701653002400720100002400744700002500768700002000793700002000813700002300833700002300856700001200879700001800891700002100909700001900930700002200949856010900971       2005                        eng d  a0040-402000aUnusual stereochemical outcome of radical cyclization: synthesis of (+)-biotin0 aUnusual stereochemical outcome of radical cyclization synthesis   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a9273-92800 v613 a<p>An enantioselective synthesis of (+)-biotin 1 starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound 10 to prepare 5,5-fused system 11, and the introduction of C4-sidechain at C-6 in 13 via a Grignard reaction. (c) 2005 Elsevier Ltd. All rights reserved.</p>10abiotin10aexocyclization10aradical cyclization1 aChavan, Subhash, P.1 aChittiboyina, A., G.1 aRamakrishna, G.1 aTejwani, R., B.1 aRavindranathan, T.1 aKamat, Subhash, K.1 aRai, B.1 aSivadasan, L.1 aBalakrishnan, K.1 aRamalingam, S.1 aDeshpande, V., H.  uhttps://library.ncl.res.in/content/unusual-stereochemical-outcome-radical-cyclization-synthesis-biotin-000864nas a2200181   4500008004100000022001400041245007600055210006800131260007100199300001400270490000700284520019800291100002400489700002000513700002400533700002300557856010200580       2006                        eng d  a0022-326300aFirst enantiospecific synthesis of (-)-parvifoline and (-)-curcuquinone0 aFirst enantiospecific synthesis of parvifoline and curcuquinone  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a8986-89880 v713 a<p>The first enantiospecific synthesis of (-)-parvifoline, employing ring-closing metathesis as the key step, and (-)-curcuquinone from naturally occurring (R)-(+)-citronellal is described.</p>1 aChavan, Subhash, P.1 aThakkar, Mahesh1 aJogdand, Ganesh, F.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/first-enantiospecific-synthesis-parvifoline-and-curcuquinone-001020nas a2200241   4500008004100000022001400041245007500055210006900130260010600199300001400305490000700319520016800326653002900494653002000523653001900543653000800562653002000570100002400590700002000614700001600634700002300650856010500673       2006                        eng d  a0040-403900aRing closing metathesis approach to the indole alkaloid mitralactonine0 aRing closing metathesis approach to the indole alkaloid mitralac  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a9301-93030 v473 a<p>An efficient utilisation of RCM leading to a convenient synthesis of a pentacyclic indole alkaloid is described. (c) 2006 Elsevier Ltd. All rights reserved.</p>10acorynanthe type alkaloid10aDihydroxylation10amitralactonine10aRCM10aSwern oxidation1 aChavan, Subhash, P.1 aSharma, Pallavi1 aSivappa, R.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/ring-closing-metathesis-approach-indole-alkaloid-mitralactonine-000888nas a2200241   4500008004100000022001400041245005200055210004600107260008600153300001400239490000700253520012400260653002000384653001400404653001700418653001800435653001600453100002400469700002800493700002200521700002300543856008000566       2007                        eng d  a0039-791100aConvenient formal synthesis of (+/-)-paroxetine0 aConvenient formal synthesis of paroxetine  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcSEP  a3143-31490 v373 a<p>A formal total synthesis of antidepressant (+/-)-paroxetine employing a solvent-free Heck reaction is disclosed.</p>10aantidepressants10acarbamate10aelectrophile10aHeck reaction10apiperidines1 aChavan, Subhash, P.1 aKhobragade, Dushant, A.1 aPathak, Ashok, B.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/convenient-formal-synthesis-paroxetine-000856nas a2200205   4500008004100000022001400041245007000055210006300125260007500188300001400263520013000277653001500407653001500422653002800437653001400465100002400479700002600503700002300529856009800552       2007                        eng d  a0039-788100aEfficient and practical total synthesis of (+/-)-alpha-cuparenone0 aEfficient and practical total synthesis of alphacuparenone  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a3827-38303 a<p>A one-pot cyclopentannulation approach as the key step for the total synthesis of (+/-)-alpha-cuparenone is described.</p>10aAlkylation10aannulation10ahydroboration-oxidation10areduction1 aChavan, Subhash, P.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/efficient-and-practical-total-synthesis-alpha-cuparenone-000890nas a2200169   4500008004100000022001400041245009700055210006900152260010600221300001200327490000700339520018100346100002400527700002600551700002300577856012000600       2007                        eng d  a0040-403900aFacile total synthesis of (+/-)-alpha-cuparenone employing diallylation and RCM as key steps0 aFacile total synthesis of alphacuparenone employing diallylation  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a965-9660 v483 a<p>A short and concise total synthesis of alpha-cuparenone employing one-pot diallylation and RCM as the key steps is described. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/facile-total-synthesis-alpha-cuparenone-employing-diallylation-and-rcm-key-steps00905nas a2200169   4500008004100000022001400041245008900055210006900144260010600213300001200319490000700331520021400338100002400552700002000576700002300596856011600619       2007                        eng d  a0040-403900aFirst enantiospecific synthesis of (-)-heritol: absolute configuration determination0 aFirst enantiospecific synthesis of heritol absolute configuratio  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a643-6460 v483 a<p>The first enantiospecific synthesis of (-)-heritol, from naturally occurring (R)-(+)-citronellal and confirmation of its absolute configuration, is described. (c) 2006 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aThakkar, Mahesh1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/first-enantiospecific-synthesis-heritol-absolute-configuration-determination01147nas a2200217   4500008004100000022001400041245012100055210006900176260008600245300001400331490000700345520031200352653001200664653001400676653002600690653001100716100002400727700002500751700002600776856012700802       2007                        eng d  a0039-791100aMgBr2-mediated ionic Diels-Alder reaction of acetals of alpha,beta-unsaturated aldehydes and ketones with 1,3-dienes0 aMgBr2mediated ionic DielsAlder reaction of acetals of alphabetau  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJUL  a2337-23430 v373 a<p>A facile, mild, and efficient methodology for the ionic Diels-Alder reaction of acetals of alpha,beta-unsaturated ketones and aldehydes as dienophiles with various 1,3- dienes employing MgBr2 as the Lewis acid catalyst to furnish corresponding Diels-Alder adducts at ambient temperature is described.</p>10aacetals10aCatalysts10aDiels-Alder reactions10adienes1 aChavan, Subhash, P.1 aEthiraj, Krishna, S.1 aDantale, Shubhada, W.  uhttps://library.ncl.res.in/content/mgbr2-mediated-ionic-diels-alder-reaction-acetals-alphabeta-unsaturated-aldehydes-and-001048nas a2200229   4500008004100000022001400041245007900055210006900134260007500203300001000278520024800288653001400536653001500550653001700565653002100582653001600603100002400619700002000643700002300663700002300686856010900709       2007                        eng d  a0936-521400aPractical and facile approach towards indole alkaloids: (-)-mitralactonine0 aPractical and facile approach towards indole alkaloids mitralact  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJAN  a79-823 a<p>An efficient approach to (-)-mitralactonine using Pictet-Spengler cyclisation with a highly functionalised masked aldehyde is described. Sharpless asymmetric dihydroxylation (SAD) is utilised to introduce chirality in the key substrate.</p>10aalkaloids10aasymmetric10acyclisations10adihydroxylations10athioacetats1 aChavan, Subhash, P.1 aSharma, Pallavi1 aSivappa, Rasapalli1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/practical-and-facile-approach-towards-indole-alkaloids-mitralactonine00989nas a2200217   4500008004100000022001400041245004700055210004700102260010600149300001400255490000700269520028000276653001300556653001500569653001700584653002000601100002400621700002200645700002300667856008100690       2007                        eng d  a0040-403900aPractical formal synthesis of camptothecin0 aPractical formal synthesis of camptothecin  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a6561-65630 v483 a<p>The synthesis of the DE ring of camptothecin using simple and inexpensive starting materials, employing an addition elimination reaction and selective esterification of an aliphatic carboxylic acid as key steps is described. (C) 2007 Elsevier Ltd. All rights reserved.</p>10aalkaloid10aAnticancer10acamptothecin10aNatural product1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/practical-formal-synthesis-camptothecin-000783nas a2200217   4500008004100000022001400041245004500055210003900100260008600139300001400225490000700239520008900246653001900335653002200354653002100376100002400397700002800421700002000449700002300469856007300492       2007                        eng d  a0039-791100aPractical synthesis of (+/-)-venlafaxine0 aPractical synthesis of venlafaxine  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcNOV  a3901-39060 v373 a<p>A practical total synthesis of antidepressant (+/-)-venlafaxine is disclosed.</p>10aantidepressant10aGrignard reaction10aMichael addition1 aChavan, Subhash, P.1 aKhobragade, Dushant, A.1 aThakkar, Mahesh1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/practical-synthesis-venlafaxine-000983nas a2200241   4500008004100000022001400041245004900055210004900104260008600153300001400239490000700253520022800260653001600488653001400504653001200518653002100530653002000551100002400571700002200595700001800617700002300635856008300658       2007                        eng d  a0039-791100aShort and efficient synthesis of rubrolide E0 aShort and efficient synthesis of rubrolide E  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcDEC  a4253-42630 v373 a<p>Short and efficient synthesis of rubrolide E from commercially available 4-methoxyacetophenone, employing ring-closing metathesis, Knoevenagel condensation, and Reformatsky reactions, are the key steps are described.</p>10aantibiotics10aantitumor10aEpoxide10aNatural products10aTotal synthesis1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aPandey, Ankur1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/short-and-efficient-synthesis-rubrolide-e-000986nas a2200217   4500008004100000022001400041245010300055210006900158260007500227300001400302520017700316653001400493653001400507653001700521653002100538653001400559100002400573700002200597700002300619856012600642       2007                        eng d  a0936-521400aTotal synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy0 aTotal synthesis of camptothecin via an intramolecular palladiumc  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcOCT  a2635-26383 a<p>The novel cascade intramolecular Pd-catalyzed cyclization followed by aromatization for the construction Of D ring of (+)-camptothecin as a key step is demonstrated.</p>10aalkaloids10aantitumor10acyclizations10aNatural products10aPalladium1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/total-synthesis-camptothecin-intramolecular-palladium-catalyzed-cyclization-strategy-000996nas a2200241   4500008004100000022001400041245005900055210005900114260008600173300001400259490000700273520021100280653001300491653002100504653002000525653000800545653002000553100002400573700002200597700002600619700002300645856008600668       2007                        eng d  a0039-791100aTotal synthesis of pulchellalactam via an RCM strategy0 aTotal synthesis of pulchellalactam via an RCM strategy  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcMAY  a1503-15100 v373 a<p>Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described.</p>10aalkaloid10aNatural products10apulchellalactam10aRCM10aTotal synthesis1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/total-synthesis-pulchellalactam-rcm-strategy-000680nas a2200145   4500008004100000022001400041245014100055210006900196260006700265490000800332100001700340700002400357700002400381856012900405       2008                        eng d  a0065-772700aORGN 511-Total synthesis of 7-chloro-10-methoxycamptothecin: an important synthon for commercially important derivatives of camptothecin0 aORGN 511Total synthesis of 7chloro10methoxycamptothecin an impor  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAmer Chem SoccAPR0 v2351 aSharma, Anil1 aChavan, Subhash, P.1 aVenkatraman, M., S.  uhttps://library.ncl.res.in/content/orgn-511-total-synthesis-7-chloro-10-methoxycamptothecin-important-synthon-commercially-001219nas a2200217   4500008004100000022001400041245012900055210006900184260007500253300001400328520036400342653002300706653001400729653001400743653002100757653002500778100002400803700002600827700002300853856012500876       2008                        eng d  a0936-521400aTandem aza-michael-condensation-aldol cyclization reaction: approach to the construction of DE synthon of (+/-)-camptothecin0 aTandem azamichaelcondensationaldol cyclization reaction approach  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcNOV  a2781-27843 a<p>An efficient synthesis of the DE ring of camptothecin, employing a Reformatsky and a tandem one-pot, three-step transformation involving aza-Michael reaction, condensation with ethyl malonyl chloride followed by intramolecular `aldol' reaction to furnish the dihydropyridone derivative from commercially available starting materials, has been achieved.</p>10aAldol cyclizations10aalkaloids10aantitumor10aNatural products10aReformatsky reaction1 aChavan, Subhash, P.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/tandem-aza-michael-condensation-aldol-cyclization-reaction-approach-construction-de-001028nas a2200181   4500008004100000022001400041245010000055210006900155260010600224300001400330490000700344520026700351100002700618700002500645700002400670700002300694856012900717       2009                        eng d  a0957-416600aOrganocatalytic enantioselective synthesis of beta-blockers: (S)-propranolol and (S)-naftopidil0 aOrganocatalytic enantioselective synthesis of betablockers Sprop  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a1767-17700 v203 a<p>An efficient enantioselective synthesis of beta-adrenergic blockers (S)-propranolol and (S)-naftopidil with &gt; 98% ee using an L-proline-catalyzed alpha-aminoxylation of an aldehyde as a key step is described. (c) 2009 Elsevier Ltd. All rights reserved.</p>1 aPanchgalle, Sharad, P.1 aGore, Rohitkumar, G.1 aChavan, Subhash, P.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/organocatalytic-enantioselective-synthesis-beta-blockers-s-propranolol-and-s-naftopidil-001100nas a2200181   4500008004100000022001400041245014500055210006900200260010600269300001400375490000700389520030100396100002700697700002400724700002400748700002300772856012300795       2010                        eng d  a0040-403900aEnantioselective synthesis of (R)-(+)-alpha-lipoic acid via proline-catalyzed sequential alpha-aminoxylation and HWE olefination of aldehyde0 aEnantioselective synthesis of Ralphalipoic acid via prolinecatal  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUL  a3587-35890 v513 a<p>An efficient enantioselective synthesis of (R)-(+)-alpha-lipoic acid is described, in high optical purity (&gt;97% ee), using L-proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step. (C) 2010 Elsevier Ltd. All rights reserved.</p>1 aPanchgalle, Sharad, P.1 aJogdand, Ganesh, F.1 aChavan, Subhash, P.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/enantioselective-synthesis-r-alpha-lipoic-acid-proline-catalyzed-sequential-alpha-001728nas a2200313   4500008004100000022001400041245014500055210006900200260010600269300001200375490000700387520055600394653001500950653002000965653001800985653001601003100002501019700002401044700003101068700002801099700002501127700002101152700002701173700001601200700002301216700002401239700002201263856012901285       2010                        eng d  a0960-894X00aFluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents0 aFluconazole analogues containing 2H14benzothiazin34Hone or 2H14b  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a722-7250 v203 a<p>As a part of our program to develop new antifungal agents, a series of fluconazole analogues was designed and synthesized wherein one of the triazole moieties in fluconazole was replaced with 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moiety. The new chemical entities thus synthesized were screened against various fungi and it was observed that the compounds 4a and 4i are potent inhibitors of Candida strains. The structure-activity relationship for these compounds is discussed. (C) 2009 Elsevier Ltd. All rights reserved.</p>10aantifungal10aBenzothiazinone10aBenzoxazinone10aFluconazole1 aBorate, Hanumant, B.1 aMaujan, Suleman, R.1 aSawargave, Sangmeshwer, P.1 aChandavarkar, Mohan, A.1 aVaiude, Sharangi, R.1 aJoshi, Vinay, A.1 aWakharkar, Radhika, D.1 aIyer, Ramki1 aKelkar, Ramesh, G.1 aChavan, Subhash, P.1 aKunte, Sunita, S.  uhttps://library.ncl.res.in/content/fluconazole-analogues-containing-2h-14-benzothiazin-34h-one-or-2h-14-benzoxazin-34h-one-000938nas a2200169   4500008004100000022001400041245008000055210006900135260010600204300001400310490000700324520026300331100002400594700002600618700002300644856010100667       2010                        eng d  a0040-403900aFormal synthesis of (+/-)-camptothecin via tricyclic lactone as key synthon0 aFormal synthesis of camptothecin via tricyclic lactone as key sy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a3099-31010 v513 a<p>Formal synthesis of (+/-)-camptothecin via CDE tricyclic lactone employing tandem Michael addition, Dieckmann condensation and addition-elimination reaction as key steps starting from glycinate is described. (C) 2010 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aDhawane, Abasaheb, N.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/formal-synthesis-camptothecin-tricyclic-lactone-key-synthon-001127nas a2200181   4500008004100000022001400041245014500055210006900200260010600269300001400375490000700389520032200396100002700718700002400745700002400769700002300793856012900816       2010                        eng d  a0957-416600aOrganocatalytic asymmetric synthesis of (-)-delta-coniceine based on sequential proline-catalyzed asymmetric alpha-amination-HWE olefination0 aOrganocatalytic asymmetric synthesis of deltaconiceine based on   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a2399-24010 v213 a<p>An efficient asymmetric synthesis of (-)-delta-coniceine via sequential proline-catalyzed asymmetric alpha-amination and Horner-Wadsworth-Emmons olefination of an aldehyde with excellent enantiomeric excess (&gt;99%) and high yields (overall yield 44%) is described. (C) 2010 Elsevier Ltd. All rights reserved.</p>1 aPanchgalle, Sharad, P.1 aBidwai, Harshad, B.1 aChavan, Subhash, P.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/organocatalytic-asymmetric-synthesis-delta-coniceine-based-sequential-proline-catalyzed-001030nas a2200181   4500008004100000022001400041245006600055210006100121260010600182300001200288490000700300520035100307100002400658700002300682700002300705700002300728856009700751       2011                        eng d  a0040-403900aAsymmetric total synthesis of (2S,3S)-3-hydroxypipecolic acid0 aAsymmetric total synthesis of 2S3S3hydroxypipecolic acid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a404-4060 v523 a<p>A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved Claisen orthoester rearrangement, Sharpless asymmetric dihydroxylation and intramolecular lactamisation of azido lactone as the key steps. (C) 2010 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aHarale, Kishor, R.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/asymmetric-total-synthesis-2s3s-3-hydroxypipecolic-acid-000886nas a2200181   4500008004100000022001400041245006800055210006300123260010600186300001200292490000700304520020100311100002400512700002300536700002300559700002300582856009900605       2011                        eng d  a0957-416600aConvenient formal synthesis of (2S,3S)-3-hydroxy pipecolic acid0 aConvenient formal synthesis of 2S3S3hydroxy pipecolic acid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a587-5900 v223 a<p>A convenient synthesis of (2S,3S)-3-hydroxy pipecolic acid starting from inexpensive and easily available L-(+)-tartaric acid has been described. (C) 2011 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aHarale, Kishor, R.1 aDumare, Nilesh, B.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/convenient-formal-synthesis-2s3s-3-hydroxy-pipecolic-acid-001135nas a2200241   4500008004100000022001400041245010800055210006900163260008600232300001800318490000700336520025300343653001900596653001600615653001800631653001300649653001200662100002700674700002200701700002400723700002300747856012300770       2011                        eng d  a0039-791100aExploration of L-proline-catalyzed -aminoxylation of aldehyde to (S)-guaifenesin-related drug molecules0 aExploration of Lprolinecatalyzed aminoxylation of aldehyde to Sg  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcMAY  aPII 9371379300 v413 a<p>[image omitted] An efficient enantioselective synthesis of (S)-guaifenesin with 99% ee using L-proline-catalyzed -aminoxylation of aldehyde as key step is described and explored for asymmetric syntheses of (S)-moprolol and (R)-methocarbamol.</p>10a-Aminoxylation10aguaifenesin10amethocarbamol10amoprolol10aProline1 aPanchgalle, Sharad, P.1 aKunte, Sunita, S.1 aChavan, Subhash, P.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/exploration-l-proline-catalyzed-aminoxylation-aldehyde-s-guaifenesin-related-drug-002041nas a2200301   4500008004100000022001400041245009000055210006900145260010600214300001400320490000700334520096800341653002401309653001601333653001401349100002501363700003101388700002401419700002801443700001601471700001601487700001701503700002301520700002401543700002401567700002601591856012201617       2011                        eng d  a0960-894X00aNovel hybrids of fluconazole and furanones: design, synthesis and antifungal activity0 aNovel hybrids of fluconazole and furanones design synthesis and   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4873-48780 v213 a<p>During our efforts to develop new antifungal agents, a number of hybrid molecules containing furanones and fluconazole pharmacophores were designed and synthesized. The new chemical entities thus synthesized were tested for their potential as antifungal agents against various fungal strains and it was observed that the compounds with general structure 7 were potent inhibitors of Candida albicans ATCC 24433, Candida glabrata ATCC 90030, Candida tropicalis ATCC 750 and Candida neoformans ATCC 34664 while the fluconazole analogues 12 exhibited antifungal activity against Candida albicans ATCC 24433 and Candida glabrata ATCC 90030. The structure-activity relationship for these compounds is discussed. The synthetic strategies used in the present work have potential to prepare a large number of compounds for further refinement of structures to obtain molecules suitable for development as antifungal drugs. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aAntifungal activity10aFluconazole10aFuranones1 aBorate, Hanumant, B.1 aSawargave, Sangmeshwer, P.1 aChavan, Subhash, P.1 aChandavarkar, Mohan, A.1 aIyer, Ramki1 aTawte, Amit1 aRao, Deepali1 aDeore, Jaydeep, V.1 aKudale, Ananada, S.1 aMahajan, Pankaj, S.1 aKangire, Gopinath, S.  uhttps://library.ncl.res.in/content/novel-hybrids-fluconazole-and-furanones-design-synthesis-and-antifungal-activity-001626nas a2200265   4500008004100000022001400041245016100055210006900216260010600285300001400391490000700405520058200412653001400994653002001008653001201028653001801040100003101058700002401089700002301113700002601136700002401162700002401186700002501210856012501235       2011                        eng d  a0040-403900aOne-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles0 aOnestep synthesis of 4alkyl3aryl26dicyanoanilines and their use   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a5491-54930 v523 a<p>A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aaldehydes10aDicyanoanilines10aindoles10aMalononitrile1 aSawargave, Sangmeshwer, P.1 aKudale, Ananada, S.1 aDeore, Jaydeep, V.1 aBhosale, Dattatry, S.1 aDivse, Jaisingh, M.1 aChavan, Subhash, P.1 aBorate, Hanumant, B.  uhttps://library.ncl.res.in/content/one-step-synthesis-4-alkyl-3-aryl-26-dicyanoanilines-and-their-use-synthesis-highly-001330nas a2200157   4500008004100000022001400041245014200055210006900197260010600266300001400372490000700386520060100393100002400994700002501018856012901043       2012                        eng d  a0957-416600aEnantioselective synthesis of the essential oil and pheromonal component ar-himachalene by a chiral pool and chirality induction approach0 aEnantioselective synthesis of the essential oil and pheromonal c  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a1410-14150 v233 a<p>The enantioselective synthesis of both isomers of ar-himachalene has been achieved starting from enantiomerically pure citronellal and p-methyl alpha-methyl styrene as an application of a chiral pool and chirality induction approach, respectively. The key reactions involved in the synthesis include the Sharpless asymmetric dihydroxylation for the induction of chirality at benzylic carbon bearing the methyl group and the use of a hypervalent iodine reagent or trimethylsilyldiazomethane (TMSCHN2) for the six to seven membered ring expansion. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aKhatod, Harshali, S.  uhttps://library.ncl.res.in/content/enantioselective-synthesis-essential-oil-and-pheromonal-component-ar-himachalene-chiral-001149nas a2200241   4500008004100000022001400041245007500055210006900130260010600199300001400305490000700319520028300326653001500609653002200624653002200646653002800668653001500696100002400711700002300735700002600758700002300784856010000807       2012                        eng d  a0040-403900aFormal synthesis of (-)-stemoamide using a useful epimerization at C-80 aFormal synthesis of stemoamide using a useful epimerization at C  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a2647-26500 v533 a<p>The formal synthesis of (-)-stemoamide was achieved starting from L-pyroglutamic acid. The key steps used are the allylation using BF3 center dot OEt2, ring closing metathesis, allylic oxidation and a novel epimerization at C8. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aAllylation10aAllylic oxidation10aPyroglutamic acid10aRing closing metathesis10aStemoamide1 aChavan, Subhash, P.1 aHarale, Kishor, R.1 aPuranik, Vedavati, G.1 aGawade, Rupesh, L.  uhttps://library.ncl.res.in/content/formal-synthesis-stemoamide-using-useful-epimerization-c-8-001041nas a2200229   4500008004100000022001400041245008300055210006900138260010600207300001400313490000700327520021200334653001500546653001600561653002000577653002900597653001400626100002400640700001900664700002300683856010500706       2012                        eng d  a0040-402000aHighly diastereoselective total synthesis of (+/-)-heritonin and (+/-)-heritol0 aHighly diastereoselective total synthesis of heritonin and herit  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a8509-85140 v683 a<p>A highly diastereoselective synthesis of heritol and heritonin by intramolecular cyclization on a preformed sensitive butenolide functionality is described. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aButenolide10acyclization10aDihydroxylation10aFriedel-Crafts acylation10aTetralone1 aChavan, Subhash, P.1 aGarai, Sumanta1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/highly-diastereoselective-total-synthesis-heritonin-and-heritol-001358nas a2200217   4500008004100000022001400041245007100055210006900126260010600195300001400301490000700315520054800322653002800870653003100898653001700929653002200946653002400968100002400992700002301016856010101039       2012                        eng d  a0040-403900aVery practical and selective method for PMB protection of alcohols0 aVery practical and selective method for PMB protection of alcoho  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4683-46860 v533 a<p>A very simple, practical and efficient one-step heterogeneous protocol for the PMB protection of alcohols using Amberlyst-15 has been developed. The stability and hazard issues regarding PMBCI and PMBBr are totally avoided by directly using anisyl alcohol for the protection. Alcohols are protected in very good yields. The selective mono-PMB protection of diols as well as di-PMB protection of diols was achieved in good yields, along with the demonstration of recyclability of the catalyst. (c) 2012 Elsevier Ltd. All rights reserved.</p>10a4-Methoxybenzyl alcohol10a4-Methoxybenzyl protection10aAmberlyst-1510aDi-PMB protection10aMono-PMB protection1 aChavan, Subhash, P.1 aHarale, Kishor, R.  uhttps://library.ncl.res.in/content/very-practical-and-selective-method-pmb-protection-alcohols-001179nas a2200217   4500008004100000022001400041245008600055210006900141260010600210300001400316490000700330520034900337653002300686653001800709653002800727653001200755653002400767100002400791700002600815856012000841       2013                        eng d  a0040-403900aOne-pot migration-formylation of benzyl aryl ethers under duff reaction condition0 aOnepot migrationformylation of benzyl aryl ethers under duff rea  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4789-47920 v543 a<p>A one-pot migration-formylation of benzyl aryl ethers under Duff reaction condition is described. The reaction was performed with HMTA (hexamethylene tetramine) and TFA (trifluoroacetic acid). Under the optimal reaction conditions, a variety of Bn and PMB ethers underwent ortho rearrangement. (C) 2013 Elsevier Ltd. All rights reserved.</p>10aBenzyl aryl ethers10aDuff reaction10aHexamethylene tetramine10aOne-pot10aortho Rearrangement1 aChavan, Subhash, P.1 aLasonkar, Pradeep, B.  uhttps://library.ncl.res.in/content/one-pot-migration-formylation-benzyl-aryl-ethers-under-duff-reaction-condition-001437nas a2200277   4500008004100000022001400041245009800055210006900153260010600222300001400328490000700342520042300349653002300772653002200795653001600817653001900833653001800852100002500870700002500895700002400920700002400944700002700968700002200995700002301017856011901040       2013                        eng d  a0040-403900aOne-step method for the synthesis of aryl olefins from aryl aldehydes and aliphatic aldehydes0 aOnestep method for the synthesis of aryl olefins from aryl aldeh  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a1528-15300 v543 a<p>A conceptually new one-step reaction affording unexpected aryl olefinic product from aromatic aldehyde, aliphatic aldehyde and malononitrile in the presence of acetic acid-ammonium acetate under mild reaction conditions without using any metal catalyst is reported. This novel reaction was used to prepare a number of substituted aryl olefins including new molecules. (c) 2013 Elsevier Ltd. All rights reserved.</p>10aAliphatic aldehyde10aAromatic aldehyde10aAryl olefin10aDicyanoaniline10aMalononitrile1 aBorate, Hanumant, B.1 aGaikwad, Supriya, H.1 aKudale, Ananada, S.1 aChavan, Subhash, P.1 aPharande, Shrikant, G.1 aWagh, Vitthal, D.1 aSawant, Vikram, S.  uhttps://library.ncl.res.in/content/one-step-method-synthesis-aryl-olefins-aryl-aldehydes-and-aliphatic-aldehydes-000998nas a2200205   4500008004100000022001400041245005500055210005000110260010600160300001400266490000700280520027400287653002800561653002700589653002000616100002400636700002300660700002300683856008600706       2013                        eng d  a0040-403900aShort synthesis of (2S,3S)-3-hydroxypipecolic acid0 aShort synthesis of 2S3S3hydroxypipecolic acid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a4851-48530 v543 a<p>A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant L-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps. (C) 2013 Elsevier Ltd. All rights reserved.</p>10aReductive lactamization10aSelective deprotection10aWittig reaction1 aChavan, Subhash, P.1 aHarale, Kishor, R.1 aPawar, Kailash, P.  uhttps://library.ncl.res.in/content/short-synthesis-2s3s-3-hydroxypipecolic-acid-000993nas a2200217   4500008004100000022001400041245008000055210006900135260007500204300001400279490000700293520023200300653002500532653001300557653001600570653002000586653000900606100002400615700002600639856011000665       2013                        eng d  a0039-788100aSimple synthesis of the novel antihistaminic drug olopatadine hydrochloride0 aSimple synthesis of the novel antihistaminic drug olopatadine hy  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a3399-34030 v453 a<p>A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain.</p>10aantihistaminic drugs10achelates10aLewis acids10aspiro compounds10azinc1 aChavan, Subhash, P.1 aLasonkar, Pradeep, B.  uhttps://library.ncl.res.in/content/simple-synthesis-novel-antihistaminic-drug-olopatadine-hydrochloride-001400nas a2200265   4500008004100000022001400041245008900055210006900144260010600213300001400319490000700333520039800340653002800738653002700766653002800793653002500821653002800846100002400874700002400898700002400922700002300946700002400969700002400993856011701017       2014                        eng d  a0040-403900aChiron approach to formal synthesis of both antipodes of cis 3-hydroxypipecolic acid0 aChiron approach to formal synthesis of both antipodes of cis 3hy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6423-64260 v553 a<p>The efficient and practical formal syntheses of both enantiomers of cis 3-hydroxypipecolic acid were accomplished from cis aziridine-2-carboxylate as the common synthetic precursor. The key steps involved are stereo and regioselective aziridine ring opening, reductive cyclization and selective N-debenzylation over O-debenzylation reactions. (C) 2014 Elsevier Ltd. All rights reserved.</p>10a3-Hydroxypipecolic acid10aAziridine ring opening10aAziridine-2-carboxylate10aPiperidine alkaloids10aSelective debenzylation1 aChavan, Subhash, P.1 aKhairnar, Lalit, B.1 aChavan, Prakash, N.1 aDumare, Nilesh, B.1 aKalbhor, Dinesh, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/chiron-approach-formal-synthesis-both-antipodes-cis-3-hydroxypipecolic-acid-001108nas a2200217   4500008004100000022001400041245011500055210006900170260010600239300001400345490000700359520021600366653002500582653003200607653002600639653002600665100002400691700002400715700002400739856012700763       2014                        eng d  a0040-403900aEfficient and mild method for preparation of allylic amines from aziridine-2-alcohols using PPh3/I-2/imidazole0 aEfficient and mild method for preparation of allylic amines from  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a5905-59070 v553 a<p>Allylic amines are synthesized in good to excellent yields by treatment of aziridine-2-alcohols with PPh3/I-2/imidazole in THF as solvent under mild conditions. (C) 2014 Elsevier Ltd. All rights reserved.</p>10aChiral allylic amine10aChiral aziridine-2-alcohols10aPPh3/iodine/imidazole10aReductive elimination1 aChavan, Subhash, P.1 aKhairnar, Lalit, B.1 aChavan, Prakash, N.  uhttps://library.ncl.res.in/content/efficient-and-mild-method-preparation-allylic-amines-aziridine-2-alcohols-using-pph3i-001373nas a2200253   4500008004100000022001400041245011200055210006900167260007500236300001400311490000700325520044500332653001900777653001100796653002300807653001500830653002500845100002400870700002400894700002600918700002400944700002500968856012600993       2014                        eng d  a0936-521400aFacile and convenient synthesis of (+/-)-Biotin via MgCl2/Et3N-mediated C-C coupling and mitsunobu reaction0 aFacile and convenient synthesis of Biotin via MgCl2Et3Nmediated   aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a2879-28820 v253 a<p>A synthesis of (+/-)-biotin is described starting from simple starting materials viz. cyclohexanone and amino malonic acid ester. The key steps involved are MgCl2/Et3N coupling of amino malonic acid ester derivative and acid chloride, Mitsunobu reaction, ozonolysis, Staudinger reduction, novel urea formation, and subsequent dibenzylation. This approach is economical and involves high-yielding steps and simple reaction conditions.</p>10aAppel reaction10abiotin10aMitsunobu reaction10aOzonolysis10aStaudinger reduction1 aChavan, Subhash, P.1 aChavan, Prakash, N.1 aLasonkar, Pradeep, B.1 aKhairnar, Lalit, B.1 aKadam, Appasaheb, L.  uhttps://library.ncl.res.in/content/facile-and-convenient-synthesis-biotin-mgcl2et3n-mediated-c-c-coupling-and-mitsunobu-001101nas a2200169   4500008004100000022001400041245007900055210006900134260011000203300001600313490000600329520041500335100002400750700002300774700002300797856011100820       2014                        eng d  a2046-206900aNovel, concise and efficient protocol for non-natural piperidine compounds0 aNovel concise and efficient protocol for nonnatural piperidine c  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a32594-325980 v43 a<p>Formal synthesis of L-altro-1-deoxynojirimycin, cis-3-hydroxypipecolic acid along with synthesis of (R)-piperidinol and a conceptually different advanced intermediate for non-natural piperidine alkaloids is reported from cis-butene-1,4-diol. The key reactions involved are Johnson-Claisen rearrangement, Sharpless asymmetric dihydroxylation, reductive lactamization and novel regioselective elimination.</p>1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aPawar, Kailash, P.  uhttps://library.ncl.res.in/content/novel-concise-and-efficient-protocol-non-natural-piperidine-compounds-000923nas a2200169   4500008004100000022001400041245009100055210006900146260000800215300001600223490000600239520032300245100002400568700002300592700001900615856011900634       2014                        eng d  a2046-206900aProtecting group free and scalable approach towards total synthesis of (-)-venlafaxine0 aProtecting group free and scalable approach towards total synthe  cFEB  a14468-144700 v43 a<p>A protecting group free asymmetric total synthesis of (-)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (-)-venlafaxine.</p>
1 aChavan, Subhash, P.1 aPawar, Kailash, P.1 aGarai, Sumanta  uhttps://library.ncl.res.in/content/protecting-group-free-and-scalable-approach-towards-total-synthesis-venlafaxine01055nas a2200181   4500008004100000022001400041245007400055210006800129260010600197300001400303490000700317520035000324100002400674700002400698700002400722700002400746856010300770       2014                        eng d  a0957-416600aShort enantioselective total synthesis of (R)- and (S)-pipecolic acid0 aShort enantioselective total synthesis of R and Spipecolic acid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a1246-12510 v253 a<p>A convenient and practical total synthesis of (R)- and (S)-pipecolic acid has been achieved by utilizing chiral cis-aziridine-2-carboxylate as the common synthetic precursor. The synthesis involves regioselective reductive cleavage of the aziridine ring and Wittig olefination as key reactions. (C) 2014 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aKhairnar, Lalit, B.1 aChavan, Prakash, N.1 aKalbhor, Dinesh, B.  uhttps://library.ncl.res.in/content/short-enantioselective-total-synthesis-r-and-s-pipecolic-acid-001060nas a2200169   4500008004100000022001400041245011800055210006900173260011000242300001600352490000600368520031200374100002400686700002400710700002400734856013200758       2014                        eng d  a2046-206900aStereospecific synthetic approach towards tamiflu using the ramberg-backlund reaction from cysteine hydrochloride0 aStereospecific synthetic approach towards tamiflu using the ramb  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a62281-622840 v43 a<p>The stereospecific formal synthesis of Tamiflu from L-cysteine hydrochloride as the chiral source is described. The notable feature of the present strategy is the Ramberg-Backlund reaction and Sharpless-Reich protocol as the key chemical transformations to access the cyclohexene skeleton of Tamiflu.</p>1 aChavan, Subhash, P.1 aChavan, Prakash, N.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/stereospecific-synthetic-approach-towards-tamiflu-using-ramberg-backlund-reaction-cysteine-000957nas a2200169   4500008004100000022001400041245010500055210006900160260011000229300001600339490000600355520023300361100002400594700002300618700002300641856012300664       2014                        eng d  a2046-206900aTotal syntheses of D-allo-1-deoxynojirimycin and L-talo-1-deoxynojirimycin via reductive cyclization0 aTotal syntheses of Dallo1deoxynojirimycin and Ltalo1deoxynojirim  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAUG  a40852-408580 v43 a<p>Synthesis of a polyhydroxypiperidine framework for L-talo-1-deoxynojirimycin and D-allo-1-deoxynojirimycin was achieved from L-tartaric acid by employing flash dihydroxylation and reductive lactamisation as the key steps.</p>1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aPawar, Kailash, P.  uhttps://library.ncl.res.in/content/total-syntheses-d-allo-1-deoxynojirimycin-and-l-talo-1-deoxynojirimycin-reductive-001060nas a2200229   4500008004100000022001400041245007600055210006900131260010600200300001400306490000700320520021400327653002700541653001000568653002000578653002800598100002300626700002500649700002400674700002500698856010700723       2014                        eng d  a0040-403900aUnusual, selective, reductive, deoxygenation of cyclopentenone alcohols0 aUnusual selective reductive deoxygenation of cyclopentenone alco  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a5241-52430 v553 a<p>A selective, reductive, deoxygenation of 2-aryl-4-hydroxycyclopent-2-en-1-ones to afford 2-aryl-cyclopent-2-en-1-ones was achieved by NaBH4-CeCl3 in methanol. (C) 2014 Elsevier Ltd. All rights reserved.</p>10aCyclopentenone alcohol10aEnone10aLuche reduction10aReductive deoxygenation1 aBavikar, Suhas, R.1 aLasonkar, Trupti, P.1 aChavan, Subhash, P.1 aBorate, Hanumant, B.  uhttps://library.ncl.res.in/content/unusual-selective-reductive-deoxygenation-cyclopentenone-alcohols-001285nas a2200241   4500008004100000022001400041245010300055210006900158260000900227300001400236490000700250520045100257653001600708653002400724653002100748653001600769653004100785100002400826700002300850700001600873700002200889856013200911       2015                        eng d  a0040-402000aChirality induction and chiron approaches to enantioselective total synthesis of alpha-lipoic acid0 aChirality induction and chiron approaches to enantioselective to  cJUN   a4213-42180 v713 a<p>An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of a-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aChiral pool10aChirality induction10aenantioselective10aLipoic acid10asharpless asymmetric dihydroxylation1 aChavan, Subhash, P.1 aPawar, Kailash, P.1 aPraveen, Ch1 aPatil, Niteen, B.  uhttps://library.ncl.res.in/content/chirality-induction-and-chiron-approaches-enantioselective-total-synthesis-alpha-lipoic-acid01293nas a2200193   4500008004100000022001400041245017600055210006900231260011000300300001600410490000600426520041900432100002400851700002400875700002300899700002400922700002300946856013000969       2015                        eng d  a2046-206900aEnantioselective syntheses of (R)-pipecolic acid, (2R,3R)-3-hydroxypipecolic acid, beta-(+)-conhydrine and (-)-swainsonine using an aziridine derived common chiral synthon0 aEnantioselective syntheses of Rpipecolic acid 2R3R3hydroxypipeco  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a50580-505900 v53 a<p>Concise total syntheses of (R)-pipecolic acid, (R)-ethyl-6-oxopipecolate, (2R, 3R)-3-hydroxypipecolic acid and formal syntheses of beta-(+)-conhydrine, (-)-lentiginosine, (-)-swainsonine and 1,2-di-epi-swainsonine have been accomplished starting from a common chiral synthon. The present strategy employs regioselective aziridine ring opening, Wittig olefination and RCM as the key chemical transformations.</p>1 aChavan, Subhash, P.1 aKhairnar, Lalit, B.1 aPawar, Kailash, P.1 aChavan, Prakash, N.1 aKawale, Sanket, A.  uhttps://library.ncl.res.in/content/enantioselective-syntheses-r-pipecolic-acid-2r3r-3-hydroxypipecolic-acid-beta-conhydrine-001167nas a2200217   4500008004100000022001400041245011500055210006900170260010600239300001200345490000700357520030800364653002900672653001600701653001800717653002000735100002400755700002300779700002300802856012400825       2015                        eng d  a0040-403900aFormal syntheses of (2R,3R)-3-hydroxy pipecolic acid and (2R,3S)-3-hydroxy pipecolic acid from L-ascorbic acid0 aFormal syntheses of 2R3R3hydroxy pipecolic acid and 2R3S3hydroxy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a805-8070 v563 a<p>Formal syntheses of both cis and trans 3-hydroxy pipecolic acids is achieved from L-ascorbic acid. Present synthesis describes use of chiral pool approach in which epimerization, Staudinger reaction and Cyclization reactions were employed as key steps. (C) 2014 Elsevier Ltd. All rights reserved.</p>10a3-Hydroxy pipecolic acid10acyclization10aEpimerization10aL-Ascorbic acid1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aPawar, Kailash, P.  uhttps://library.ncl.res.in/content/formal-syntheses-2r3r-3-hydroxy-pipecolic-acid-and-2r3s-3-hydroxy-pipecolic-acid-l-001159nas a2200253   4500008004100000022001400041245013500055210006900190260007500259300001200334490000700346520024200353653001700595653001600612653001600628653001200644653001500656653001600671653002800687100002400715700002200739700002300761856012100784       2015                        eng d  a0039-788100aSynthesis of 3-ethyl-4-metyl-1h,5-dihydro-2h-pyrrol-2-one by novel palladium(ii)-catalyzed cyclization and ring-closing metathesis0 aSynthesis of 3ethyl4metyl1h5dihydro2hpyrrol2one by novel palladi  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcAPR  a955-9600 v473 a<p>Synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one is described starting from commercially available allylamine and 4-methoxybenzylamine employing palladium-catalyzed cyclization or ring-closing metathesis as the key steps.</p>10aantidiabetic10acyclization10aglimepiride10alactams10ametabolite10apyrrolinone10aRing-closing metathesis1 aChavan, Subhash, P.1 aPathak, Ashok, B.1 aPawar, Kailash, P.  uhttps://library.ncl.res.in/content/synthesis-3-ethyl-4-metyl-1h5-dihydro-2h-pyrrol-2-one-novel-palladiumii-catalyzed01295nas a2200193   4500008004100000022001400041245012000055210006900175260010600244300001200350490000700362520048500369100002500854700002300879700002200902700002300924700002400947856013000971       2015                        eng d  a0957-416600aTotal synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution0 aTotal synthesis of Rlipoic acid and Slipoic acid via an Mn IIIsa  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a281-2870 v263 a<p>The asymmetric synthesis of both the antipodes of alpha-lipoic acid is described. The total synthesis of racemic and asymmetric lipoic acid is achieved from propane 1,3-diol. This work reports the use of Mn (III)-salen-catalyzed oxidative kinetic resolution as the key step to obtain enantiomerically pure (R)- and (S)-lipoic acid. The undesired product formed during the resolution can be recycled to achieve the desired isomer. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aPurude, Abhijeet, N.1 aPawar, Kailash, P.1 aPatil, Niteen, B.1 aKalkote, Uttam, R.1 aChavan, Subhash, P.  uhttps://library.ncl.res.in/content/total-synthesis-r-lipoic-acid-and-s-lipoic-acid-mn-iii-salen-catalyzed-oxidative-kinetic-001097nas a2200217   4500008004100000022001400041245006000055210005700115260011700172300001200289520025200301653004500553653003000598653004100628100002400669700002300693700002300716700002400739700002400763856009200787       2016                        eng d  a1551-700400aAsymmetric total synthesis of L-allo-1-deoxynojirimycin0 aAsymmetric total synthesis of Lallo1deoxynojirimycin  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcOCT  a137-1473 a<p>Asymmetric total synthesis of L-allo-1-deoxynojirimycin (L-allo-DNJ) was achieved from cis-butene-1,4-diol by employing Sharpless asymmetric dihydroxylation, stereoselective flash dihydroxylation and ring enlargement reactions as key steps.</p>10adiastereoselective flash dihydroxylation10aring-enlargement reaction10asharpless asymmetric dihydroxylation1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aPawar, Kailash, P.1 aChavan, Prakash, N.1 aKhairnar, Lalit, B.  uhttps://library.ncl.res.in/content/asymmetric-total-synthesis-l-allo-1-deoxynojirimycin01621nas a2200181   4500008004100000022001400041245018100055210006900236260011000305300001600415490000600431520079500437100002401232700002501256700001501281700001701296856012601313       2016                        eng d  a2046-206900aExploration of the diastereoselectivity in an unusual Grignard reaction and its application towards the synthesis of styryl lactones 7-epi-(+)-goniodiol and 8-epi-(-)-goniodiol0 aExploration of the diastereoselectivity in an unusual Grignard r  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a50721-507250 v63 a<p>An unusual diastereoselective Grignard reaction is explored, where the Grignard reagents are derived from 1,n-dihaloalkanes. A steric bias due to the presence of a quaternary centre adjacent to the acetonide ester at the benzylic position is responsible for the formation of an intramolecularly reduced product in almost quantitative yield. This steric hindrance is responsible for the diastereoselectivity observed with a variety of aromatic as well as aliphatic esters. The unusual Grignard reaction furnishes long chain secondary alcohols possessing a terminal olefin, which are synthetically important intermediates. As an application of this method, the diastereoselective synthesis of styryl lactones viz. 7-epi-(+)-goniodiol (29) and 8-epi(-)-goniodiol (30) has been achieved.</p>1 aChavan, Subhash, P.1 aKhatod, Harshali, S.1 aDas, Tamal1 aVanka, Kumar  uhttps://library.ncl.res.in/content/exploration-diastereoselectivity-unusual-grignard-reaction-and-its-application-towards01054nas a2200145   4500008004100000245012200041210006900163260000800232300001400240490000700254520047300261100002400734700002500758856012500783       2017                        eng d00aApplication of unusual grignard reaction for the stereoselective synthesis of antidepressant drug (R)-(-)-venlafaxine0 aApplication of unusual grignard reaction for the stereoselective  cMAR  a1410-14180 v493 aAn enantioselective synthesis of antidepressant drug (R)-(-)-venlafaxine is accomplished as an application of recently explored unusual Grignard reaction. An innovative method for the generation of chirality at extremely reactive benzylic center along with determination of absolute stereochemistry has been discussed. The key steps involved in the synthesis include Sharpless asymmetric dihydroxylation for the induction of chirality and an unusual Grignard reaction.1 aChavan, Subhash, P.1 aKhatod, Harshali, S.  uhttps://library.ncl.res.in/content/application-unusual-grignard-reaction-stereoselective-synthesis-antidepressant-drug-r02168nas a2200205   4500008004100000245010200041210006900143260000800212490000800220520142500228100002201653700002301675700001701698700002401715700002501739700001901764700002401783700002501807856013001832       2017                        eng d00aHybrids of thienopyrimidinones and thiouracils as anti-tubercular agents: SAR and docking studies0 aHybrids of thienopyrimidinones and thiouracils as antitubercular  cJAN0 v1273 a<p>A number of hybrid molecules containing thienopyrimidinones and thiouracil moieties were designed, synthesized and tested against Mycobacterium tuberculosis H37Ra wherein it was observed that the compounds 11-1514 exhibited antitubercular activity in vitro (MIC 7.6–19.1 μg/ml, 12–35 μM) against dormant stage while compound 15 exhibited antitubercular activity in vitro against dormant (MIC 23.4 μg/ml, 41 μM) as well as active (MIC 25.4 μg/ml, 45 μM) stage. Structural modifications of compound 15 were carried out to study the structure-activity relationship and it was observed that compound 18 exhibited antitubercular activity comparable to compound 15. Cytotoxicity studies revealed that these molecules were non-toxic. The docking study of compound 15 showed that there was binding with the active site of mycobacterial pantothenate synthetase. Further docking studies led to the synthesis of the compounds 16 and 17 and the antitubercular activity screening results showed that these compounds have significant antitubercular activity. The compounds 15-18 (MIC 11–29 μg/ml, 19–51 μM) can be used as starting points for further optimization. The synthetic strategies used in the present work have potential to prepare a large number of compounds for further refinement of structures and the present results will be very useful in the development of a new class of antimycobacterial agents.</p>1 aPisal, Mahesh, M.1 aNawale, Laxman, U.1 aPatil, Manoj1 aBhansali, Sujit, G.1 aGajbhiye, Jayant, M.1 aSarkar, Dhiman1 aChavan, Subhash, P.1 aBorate, Hanumant, B.  uhttps://library.ncl.res.in/content/hybrids-thienopyrimidinones-and-thiouracils-anti-tubercular-agents-sar-and-docking-studies01595nas a2200205   4500008004100000245010600041210006900147260000800216300001200224490000700236520087100243100002201114700002501136700002501161700001701186700002401203700001901227700002501246856011801271       2017                        eng d00aSynthesis and cell imaging applications of fluorescent mono/di/tri-heterocycl- yl-2,6-dicyanoanilines0 aSynthesis and cell imaging applications of fluorescent monoditri  cDEC  a979-9880 v273 a<p>Synthesis of 3,4,5-triheterocyclyl-2,6-dicyanoanilines, starting from heterocyclic aldehydes and 1,2-diheterocycle-substituted ethanones, is described. 2,6-Dicyanoanilines with one or two heterocyclic substituents have also been synthesized. It was found that some of these molecules have selective cell-staining properties useful for cell imaging applications. The compounds 1g, 10f and 11 were found to stain cytoplasm of the cells in contact but not the nucleus while the compound 12 showed affinity to apoptotic cells resulting in blue fluorescence. The cell imaging results with compound 12 were similar to Annexin V-FITC, a known reagent containing recombinant Annexin V conjugated to green-fluorescent FITC dye, used for detection of apoptotic cells. These compounds were found to be non-cytotoxic and have potential application as cell imaging agents.</p>1 aPisal, Mahesh, M.1 aAnnadate, Ritesh, A.1 aAthalye, Meghana, C.1 aKumar, Dipak1 aChavan, Subhash, P.1 aSarkar, Dhiman1 aBorate, Hanumant, B.  uhttps://library.ncl.res.in/content/synthesis-and-cell-imaging-applications-fluorescent-monoditri-heterocycl-yl-2601580nas a2200181   4500008004100000022001400041245019800055210006900253260000900322300001400331490000700345520082500352100002401177700002501201700002601226700002401252856012201276       2018                        eng d  a1523-706000aSynthesis of 3-azidopiperidine skeleton employing ceric ammonium nitrate (CAN)-mediated regioselective azidoalkoxylation of enol ether: total synthesis of d-2 receptor agonist (+/-)-quinagolide0 aSynthesis of 3azidopiperidine skeleton employing ceric ammonium   cNOV   a7011-70140 v203 aThe total synthesis of (+/-)-quinagolide, which is a D-2 receptor agonist, was accomplished via a ceric ammonium nitrate (CAN)-mediated regioselective azidoalkoxylation of enol ether route. Key features of the synthesis include Claisen rearrangement, PPTS (pyridinium p-toluene-sulfonate)-catalyzed one-pot acetal deprotection, followed by a diastereoselective Henry reaction, which enables construction of the required trans ring junction and CAN-mediated regioselective azidoalkoxylation of enol ether. The PPTS-catalyzed intramolecular diastereoselective Henry reaction to fix three contiguous stereocenters on tetrahydronaphthalene and the first-of-its-kind synthesis of the 3-azidopiperidine skeleton, using a CAN -mediated regioselective azidoalkoxylation of enol ether, are important findings of the present work.1 aChavan, Subhash, P.1 aKadam, Appasaheb, L.1 aLasonkar, Pradeep, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/synthesis-3-azidopiperidine-skeleton-employing-ceric-ammonium-nitrate-can-mediated01433nas a2200169   4500008004100000022001400041245006300055210005900118260000800177300001400185490000700199520089300206100002401099700002501123700002401148856009101172       2019                        eng d  a1523-706000aEnantioselective formal total synthesis of (-)-quinagolide0 aEnantioselective formal total synthesis of quinagolide  cNOV  a9089-90930 v213 a<p>The enantioselective formal total synthesis of (-)-quinagolide has been accomplished in a linear sequence of 8 purification steps from pyridine. The key steps are (a) organocatalyzed Diets-Alder reaction for fixing all three stereocenters on piperidine ring; (b) protecting group enabled deoxygenation of isoquinuclidine skeleton under Birch reduction condition; (c) Lewis acid (TiCl4) catalyzed intramolecular Friedel-Crafts cyclization of dicarboxylic acid; and (d) one-pot diastereoselective ketone reduction-intramolecular cyclization to form oxazolidinone which enables trans-geometry installation. During the course of the synthesis, an interesting reductive cleavage of the C-N bond in the electron-deficient isoquinuclidine skeleton under the Birch reduction conditions has been observed. This is the first synthetic effort to access the core skeleton of (-)-quinagolide.</p>
1 aChavan, Subhash, P.1 aKadam, Appasaheb, L.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/enantioselective-formal-total-synthesis-quinagolide01283nas a2200217   4500008004100000022001400041245016000055210006900215260000800284300001100292490000700303520044500310653002400755653003900779653001600818653003700834100002400871700002300895700002400918856012300942       2019                        eng d  a0040-403900aFormal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction0 aFormal synthesis of brivaracetam a key to construct the pyrrolid  cNOV  a1512490 v603 a<p>A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield. (C) 2019 Published by Elsevier Ltd.</p>
10aAntiepileptic drugs10aPd-catalyzed oxidative cyclization10apyrrolinone10aRing-closing metathesis reaction1 aChavan, Subhash, P.1 aKawale, Sanket, A.1 aChavan, Prakash, N.  uhttps://library.ncl.res.in/content/formal-synthesis-brivaracetam-key-construct-pyrrolidone-scaffold-using-pd-catalyzed01666nas a2200169   4500008004100000022001400041245011200055210006900167260000800236300001400244490000600258520103600264100002401300700002501324700002301349856012401372       2019                        eng d  a2470-134300aTotal synthesis of (+/-)-quinagolide: a potent D-2 receptor agonist for the treatment of hyperprolactinemia0 aTotal synthesis of quinagolide a potent D2 receptor agonist for   cMAY  a8231-82380 v43 a<p>A potent dopamine (D-2) receptor agonist (+/-)-quinagolide, which is used for the treatment of hyperprolactinemia, was synthesized using the ring closing metathesis (RCM) approach from meta-hydroxybenzaldehyde as the starting material. The key features of this synthesis are pyrolytic elimination, late-stage expedient synthesis of functionalized trans-fused tetrahydropyridine-3-carboxylates from olefin 6, via conjugate addition-elimination upon acetate 11, followed by RCM and phenyliodine bis(trifluoroacetate) (PIFA)-mediated Hofmann rearrangement of piperidine-3-carboxamide, which enables the synthesis of 3-aminopiperidine skeleton of quinagolide. For the total synthesis of natural products such as ergot alkaloids, late-stage synthesis of functionalized trans-fused tetrahydropyridine-3-carboxylates using RCM and PIFA-mediated Hofmann rearrangement of piperidine-3-carboxamide, which allows quick access to the synthetically challenging 3-aminopiperidine skeleton, are the main achievements of the present work.</p>
1 aChavan, Subhash, P.1 aKadam, Appasaheb, L.1 aKawale, Sanket, A.  uhttps://library.ncl.res.in/content/total-synthesis-quinagolide-potent-d-2-receptor-agonist-treatment-hyperprolactinemia00731nas a2200193   4500008004100000022001400041245011300055210006900168260000900237300001100246490000700257100002400264700002400288700002400312700002300336700002400359700002400383856013000407       2020                        eng d  a0040-403900aChiron approach to formal synthesis of both antipodes of cis 3-hydroxypipecolic acid (vol 55, pg 6423, 2014)0 aChiron approach to formal synthesis of both antipodes of cis 3hy  cDEC   a1526440 v611 aChavan, Subhash, P.1 aKhairnar, Lalit, B.1 aChavan, Prakash, N.1 aDumare, Nilesh, B.1 aKalbhor, Dinesh, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/chiron-approach-formal-synthesis-both-antipodes-cis-3-hydroxypipecolic-acid-vol-55-pg-642301338nas a2200241   4500008004100000022001400041245014300055210006900198260000800267300001100275490000700286520050900293653003700802653002000839653001400859653001000873100002100883700000500904700001600909700002400925700002200949856012500971       2020                        eng d  a0040-403900aEnolate-mediated regioselective synthesis of 1,2,3-triazoles via azide-aldehydes or ketones [3+2]-cycloaddition reactions in aqueous phase0 aEnolatemediated regioselective synthesis of 123triazoles via azi  cMAR  a1516620 v613 a<p>A synthetic route for the direct conversion of arylazides into the corresponding trizoles via phase transfer catalyst-assisted [3+2] cycloaddition reaction under basic conditions in aqueous medium is reported. This synthetic methodology, which offers high yields and excellent regioselectivity for varieties of triazoles at 100 degrees C for 24 h-48 h and this `greener' synthesis constitutes an alternative to the previously reported well established click reactions. Published by Elsevier Ltd.</p>
10aAzides plus aldehydes or ketones10aClick chemistry10atriazoles10aWater1 aTripathi, Anupam1 a1 aLlop, Jordi1 aChavan, Subhash, P.1 aJoshi, Sameer, M.  uhttps://library.ncl.res.in/content/enolate-mediated-regioselective-synthesis-123-triazoles-azide-aldehydes-or-ketones-3201380nas a2200241   4500008004100000022001400041245016500055210006900220260000900289300001200298490000700310520049500317653002200812653002100834653002500855653001900880653001200899100002400911700002500935700002800960700002400988856012601012       2020                        eng d  a1861-472800aFuran-derived chiral bicycloaziridino lactone synthon: collective syntheses of oseltamivir phosphate (Tamiflu), (S)-pipecolic acid and its 3-hydroxy derivatives0 aFuranderived chiral bicycloaziridino lactone synthon collective   cFEB   a415-4240 v153 a<p>A unified synthetic strategy for oseltamivir phosphate (tamiflu), (S)-pipecolic acid, and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are the short (4-steps), enantiopure, and decagram-scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.</p>
10aAziridine synthon10aChiral auxiliary10acollective synthesis10aPipecolic acid10aTamiflu1 aChavan, Subhash, P.1 aKadam, Appasaheb, L.1 aShinde, Shrikrishna, S.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/furan-derived-chiral-bicycloaziridino-lactone-synthon-collective-syntheses-oseltamivir01431nas a2200253   4500008004100000022001400041245013700055210006900192260000800261300001400269490000700283520055100290653002200841653001500863653001600878653001200894653002300906100002400929700002200953700002200975700002500997700002801022856012701050       2020                        eng d  a0039-788100aScalable synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one: an important building block of the antidiabetic drug glimepiride0 aScalable synthesis of 3Ethyl4methyl15dihydro2Hpyrrol2one an impo  cNOV  a3480-34840 v523 a<p>A four-step, practical, and easily scalable synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one, an important building block of the antidiabetic drug glimepiride, has been accomplished. Key features are the synthesis of 3-methyl-4-hydroxy-2-butenolide in water and triflic acid mediated N-benzyl lactam N-deprotection. The main advantages of this process are the scalable synthetic route and decreased number of reaction steps, which paves the way for the industrial-scale synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one.</p>
10aantidiabetic drug10aButenolide10aglimepiride10alactams10ascalable synthesis1 aChavan, Subhash, P.1 aPawar, Ambaji, A.1 aPatil, Niteen, B.1 aKadam, Appasaheb, L.1 aShinde, Shrikrishna, S.  uhttps://library.ncl.res.in/content/scalable-synthesis-3-ethyl-4-methyl-15-dihydro-2h-pyrrol-2-one-important-building-block01085nas a2200241   4500008004100000022001400041245016100055210006900216260000900285300001100294490000700305520021100312653001600523653002400539653002000563653001900583653001700602100002400619700002300643700002200666700002400688856013100712       2021                        eng d  a0040-403900aApplication of allylic amine formation from aziridine-2-ol under appel reaction condition: synthesis of N-(tert-butoxycarbonyl)-D-vinyl glycine methyl ester0 aApplication of allylic amine formation from aziridine2ol under a  cJUN   a1531190 v733 a<p>PPh3/I-2/imidazolde mediated allyl amine formation from aziridine-2-alcohol was explored for the synthesis of N-(tert-butoxycarbonyl)-D-vinyl glycine methyl ester. (C) 2021 Published by Elsevier Ltd.</p>10aAllyl amine10aAziridine-2-alcohol10aAziridinium ion10aBirch reaction10aRing opening1 aChavan, Subhash, P.1 aKawale, Sanket, A.1 aPatil, Niteen, B.1 aKalbhor, Dinesh, B.  uhttps://library.ncl.res.in/content/application-allylic-amine-formation-aziridine-2-ol-under-appel-reaction-condition-synthesis01589nas a2200229   4500008004100000022001400041245014100055210006900196260000800265300001100273490000700284520076600291653001801057653002101075653002101096653002501117653001901142100002401161700002401185700002401209856012601233       2021                        eng d  a0040-402000aDivergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent0 aDivergent approach to the synthesis of balanol heterocycle and c  cJAN  a1317730 v803 a<p>Enantioselective synthesis of the hexahydroazepine core of (-)-balanol and formal synthesis of cis-3hydroxypipecolic acid from a common intermediate have been accomplished by a divergent path. The common intermediate was accessed from a favorably protected enantiomerically pure 2-amino-1,3,4-butanetriol (ABT) equivalent via oxidation and Wittig olefination. The synthesis of (-)-balanol heterocycle featured tandem reduction/acetal-deprotection/gamma-lactonization reaction and a one-pot azide reduction followed by seven membered aza-heterocycle formation while the route to cis-3-hydroxypipecolic acid highlighted the base induced piperidine ring formation and regioselective benzylidine-acetal cleavage. (C) 2020 Elsevier Ltd. All rights reserved.</p>
10aAmino-alcohol10adesymmetrization10aHexahydroazepine10aPiperidine alkaloids10aProtein kinase1 aChavan, Subhash, P.1 aKalbhor, Dinesh, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/divergent-approach-synthesis-balanol-heterocycle-and-cis-3-hydroxypipecolic-acid-based01312nas a2200193   4500008004100000022001400041245016900055210006900224260000900293300001400302490000700316520055000323100002400873700002300897700002200920700002500942700002400967856012700991       2021                        eng d  a0022-326300aFormal synthesis of (-)-quinagolide: diastereoselective ring expansion via a bicyclic aziridinium ion strategy to access the octahydrobenzo[g]quinoline architecture0 aFormal synthesis of quinagolide diastereoselective ring expansio  cJUL   a9344-93520 v863 aThe diastereoselective formal synthesis of (-)-quinagolide, a D-2 receptor agonist, has been achieved. The synthesis started from L-pyroglutamic acid and relied on utilization of (a) a stereospecific catalytic hydrogenation and diastereoselective Horner-Emmons-Michael cascade to obtain functionalized prolinate, (b) a Lewis acid mediated Pummerer cyclization to construct a tricyclic fused ring system, and (c) a diastereoselective ring expansion via a bicyclic aziridinium intermediate to access the required 3-substituted piperidine scaffold.1 aChavan, Subhash, P.1 aKawale, Sanket, A.1 aPisal, Mahesh, M.1 aKadam, Appasaheb, L.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/formal-synthesis-quinagolide-diastereoselective-ring-expansion-bicyclic-aziridinium-ion01605nas a2200241   4500008004100000022001400041245010400055210006900159260000900228300001600237490000700253520076200260653002001022653003201042653001601074653002401090653002701114100002201141700002601163700002401189700002301213856012701236       2021                        eng d  a0947-653900aMulti-step synthesis of miltefosine: integration of flow chemistry with continuous mechanochemistry0 aMultistep synthesis of miltefosine integration of flow chemistry  cDEC   a17695-176990 v273 aHerein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3(rd) step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 % overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day.10acontinuous flow10acontinuous mechanochemistry10amiltefosine10amultistep synthesis10areactive intermediates1 aPatil, Niteen, B.1 aAtapalkar, Ranjit, S.1 aChavan, Subhash, P.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/multi-step-synthesis-miltefosine-integration-flow-chemistry-continuous-mechanochemistry00759nas a2200205   4500008004100000022001400041245012700055210006900182260000900251300001100260490000700271100002200278700002500300700002500325700001800350700002400368700001900392700002500411856011700436       2021                        eng d  a0960-894X00aSynthesis and cell imaging applications of fluorescent mono/di/tri-heterocyclyl-2,6-dicyanoanilines (vol 27, pg 979, 2017)0 aSynthesis and cell imaging applications of fluorescent monoditri  cJAN   a1277370 v321 aPisal, Mahesh, M.1 aAnnadate, Ritesh, A.1 aAthalye, Meghana, C.1 aKumar, Deepak1 aChavan, Subhash, P.1 aSarkar, Dhiman1 aBorate, Hanumant, B.  uhttps://library.ncl.res.in/content/synthesis-and-cell-imaging-applications-fluorescent-monoditri-heterocyclyl-2601319nas a2200229   4500008004100000022001400041245011100055210006900166260000900235300001500244490000900259520055000268653001400818653001600832653001700848653001500865653001200880100002400892700002300916700002400939856012600963       2022                        eng d  a1434-193X00acis-aziridine synthon based synthetic investigation for tamiflu employing horner-wadsworth-emmons reaction0 acisaziridine synthon based synthetic investigation for tamiflu e  cJUL   ae2022003840 v20223 a<p>
	Synthetic investigations to achieve a novel intermediate of Tamiflu by using cis-aziridine as a chiral building block, which is readily synthesized from (D)-mannitol as a renewable starting material, has been presented. The present approach utilizes the intramolecular Horner-Wadsworth-Emmons reaction as the key step for the synthesis of Tamiflu. On the other hand, diene containing allylic aziridine framework is found to be inefficient to furnish the six-membered core skeleton of Tamiflu through ring-closing metathesis reaction.</p>
10aAziridine10acyclization10aHWE reaction10aMetathesis10aTamiflu1 aChavan, Subhash, P.1 aKawale, Sanket, A.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/cis-aziridine-synthon-based-synthetic-investigation-tamiflu-employing-horner-wadsworth01145nas a2200169   4500008004100000022001400041245013500055210006900190260000900259300001600268490000600284520048300290100002400773700002400797700002400821856013000845       2022                        eng d  a2470-134300aRapid synthesis of the epi-biotin sulfone via tandem S,N-carbonyl migration/aza-michael/spirocyclization and haller-bauer reaction0 aRapid synthesis of the epibiotin sulfone via tandem SNcarbonyl m  cMAY   a17215-172220 v73 a<p>
	A synthesis of 2-epi-biotin sulfone was accomplished from commercially available L-cysteine. The synthesis features an unprecedented tandem S,N-carbonyl migration/aza-Michael/spirocyclization reaction from an L-cysteine-derived enone with aq. ammonia, in which three new sigma bonds and two rings are formed. In addition, the synthesis includes a highly diastereoselective late-stage Haller-Bauer reaction of sulfone for direct introduction of the carbon side chain.</p>
1 aChavan, Subhash, P.1 aKalbhor, Dinesh, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/rapid-synthesis-epi-biotin-sulfone-tandem-sn-carbonyl-migrationaza-michaelspirocyclization01634nas a2200253   4500008004100000022001400041245011000055210006900165260000800234300001500242490000600257520078100263653001501044653002101059653002301080653001801103653001701121100002401138700002301162700002101185700002501206700002401231856012501255       2022                        eng d  a2365-654900aRevisiting classical pummerer cyclization reaction: a key strategy for the synthesis of (+/-)-quinagolide0 aRevisiting classical pummerer cyclization reaction a key strateg  cJUL  ae2022016000 v73 a<p>
	A formal synthesis of (+/-)-quinagolide using beta-alanine as a starting material has been achieved. Late stage intramolecular classical Pummerer reaction has been used as a key synthetic tool to construct octahydrobenzo[g]quinoline skeleton of quinagolide. Conjugative reduction of olefin, regioselective C-alkylation over O-alkylation of beta-ketoester followed by retro-Dieckmann/ Dieckmann reaction sequence has been used as a key reaction sequence to achieve prerequisite sulfoxide for the Pummerer reaction. While revisiting the classical Pummerer reaction, the one-pot sequential thionium ion induced cyclocarbamation followed by N-carbamate deprotection and Friedel-Crafts type Pummerer cyclization was observed as an important finding of the present work.</p>
10aAlkylation10aCyclocarbamation10aHyperprolactinemia10arearrangement10aThionium ion1 aChavan, Subhash, P.1 aKawale, Sanket, A.1 aTripathi, Anupam1 aKadam, Appasaheb, L.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/revisiting-classical-pummerer-cyclization-reaction-key-strategy-synthesis-quinagolide01321nas a2200217   4500008004100000022001400041245009100055210006900146260000800215490000700223520058800230653001400818653002500832653002600857653001600883653002100899100002400920700002400944700002400968856011100992       2023                        eng d  a2193-580700aRapid bioinspired N-acyliminium ion strategy for the ABC core of the stemona alkaloids0 aRapid bioinspired Nacyliminium ion strategy for the ABC core of   cSEP0 v123 a<p>
	A concise and highly diastereoselective bioinspired key cationic cyclization strategy for the asymmetric synthesis of the tricyclic core of the (-)-stemoamide, together with 8,9-bis-epi-stemoamide has been described. The key N-acyliminium ion precursors were accessed from L-tartaric acid and L-malic acid respectively. The use of ethyl acetoacetate derived bifunctional allylidenetriphenylphosphorane reagent in the early stage of the synthetic strategy is advantageous for the rapid construction of highly functionalized key pyrrolo[1,2-&amp; alpha;]azepine frameworks.</p>
10aalkaloids10aBiomimetic synthesis10aClaisen rearrangement10acyclization10aRegioselectivity1 aChavan, Subhash, P.1 aKalbhor, Dinesh, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/rapid-bioinspired-n-acyliminium-ion-strategy-abc-core-stemona-alkaloids01369nas a2200241   4500008004100000022001400041245014000055210007000195260000900265300001100274490000700285520049300292653002300785653001900808653002400827653003200851653001600883100002300899700002000922700002300942700002400965856013800989       2025                        eng d  a2365-654900aFormal Synthesis of Corynanthe Indole Alkaloid (±)-Mitralactonine: Construction of α-Hydroxy-Keto Functionalized Tetracyclic Skeleton0 aFormal Synthesis of Corynanthe Indole Alkaloid ±Mitralactonine C  cDEC   ae044150 v103 a<p>
	An efficient synthesis of a tetracyclic skeleton common to many corynanthe alkaloids was accomplished in 10 linear steps starting from a known tetrahydro beta-carboline intermediate. The tetracyclic alpha-hydroxy keto functionalized advanced precursor of (+/-)-mitralactonine was realized using Wittig olefination, ketohydroxylation of a trisubstituted alkene, and a tandem amine unmasking-intramolecular nucleophilic displacement reaction for C-N bond formation of C/D-rings.</p>
10aalpha-hydroxy keto10abeta-carboline10acorynanthe alkaloid10aintramolecular N-alkylation10amitragynine1 aDumare, Nilesh, B.1 aSharma, Pallavi1 aSivappa, Rasapalli1 aChavan, Subhash, P.  uhttps://library.ncl.res.in/content/formal-synthesis-corynanthe-indole-alkaloid-%C2%B1-mitralactonine-construction-%CE%B1-hydroxy-keto