01458nas a2200217   4500008004100000022001400041245006500055210006500120260000900185300001400194490000900208520077500217653002800992653001501020653001601035653000801051653004701059100002101106700002101127856009201148       2021                        eng d  a1434-193X00aTotal synthesis of a hypothetical macroketone of migrastatin0 aTotal synthesis of a hypothetical macroketone of migrastatin  cJUN   a3050-30530 v20213 aDanishefsky's macroketone, a simplified analogue of natural product Migrastatin, is one of the lead compounds with potent cancer cell migration inhibition potential. Different biological assays suggest fascin protein as the potential target. Although it was indicated through X-ray co-crystallography where the concerned macroketone analogue was found to bind in the actin-binding sites of fascin, there was a structural discrepancy, as the X-ray co-crystal structure suggested an E-olefin along with inversion of methyl stereochemistry from that of Danishefsky's macroketone. Here, we have accomplished the total synthesis of the `hypothetical macroketone' for the first time. The TiCl4 mediated vinylogous Mukaiyama aldol reaction is the key step in present synthesis.10aHypothetical mecroketon10aMetastasis10aMigrastatin10aRCM10avinylogous Mukaiyama aldol reaction (VMAR)1 aChoudhury, Rahul1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/total-synthesis-hypothetical-macroketone-migrastatin