01525nas a2200193   4500008004100000022001400041245007400055210006900129260000900198520088800207653001101095653001901106653002001125653001601145653002101161100002601182700002001208856010301228       2021                        eng d  a0039-788100aAdvances in transition-metal-catalyzed C-H bond oxygenation of amides0 aAdvances in transitionmetalcatalyzed CH bond oxygenation of amid  cAPR 3 a<p>C-O bond formation represents a fundamental chemical transformation in organic synthesis to develop valuably oxygenated (hetero)arenes. Particularly, the direct and regioselective C-H bond oxygenation of privileged amides, using a transition metal catalyst and a mild oxygenating source, is a step-economy and attractive approach. During the last decade, considerable progress has been realized in the direct C-H oxygenation of primary, secondary, and tertiary amides. This Short Review compiles the advances in transition-metal-catalyzed oxygenation of C(sp(2))-H and C(sp(3))-H bonds on various amides with diverse oxygenation sources. The review is categorized into two different major sections: (i) C(sp(2))-H oxygenation and (ii) C(sp(3))-H oxygenation. Each section is discussed based on the directing group (monodentate and bidentate) attached to the amide derivatives.</p>10aAmides10aC-H activation10adirecting group10aOxygenation10aTransition Metal1 aVijaykumar, Muniyappa1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/advances-transition-metal-catalyzed-c-h-bond-oxygenation-amides02021nas a2200217   4500008004100000022001400041245011000055210006900165260000800234490000700242520126500249653001901514653001201533653001401545653001901559653002601578100002601604700002401630700002001654856012901674       2025                        eng d  a1867-388000aPalladium-catalyzed regioselective C(4)-H fluoroalkoxylation of indoles through weak chelation assistance0 aPalladiumcatalyzed regioselective C4H fluoroalkoxylation of indo  cJAN0 v173 a<p>
	Installing fluoroalkyl motifs into biorelevant indoles is particularly interesting due to their ubiquitous presence in drug molecules. Herein, we demonstrate the regioselective C4 fluoroalkoxylation of indoles using fluoroalcohols via palladium-catalyzed chelation-assisted C &amp; horbar;H activation. The weak chelating benzoyl moiety at the C3 position acts as a directing group for remote C(4)&amp; horbar;H fluoroalkoxylation of diversely substituted indoles. This methodology demonstrates a high level of regioselectivity and tolerates a range of crucial functional groups, yielding diverse trifluoroalkoxylated indoles in moderate to good yields. Removal of directing/protecting groups and further functionalization established the synthetic utility of the methodology. A preliminary mechanistic investigation is conducted by isolating the palladacycle intermediate and performing the deuterium scrambling study. The regioselective C4 fluoroalkoxylation of indoles with various fluoroalcohols is achieved by the palladium-catalyzed weak chelation assistance strategy. The reaction is compatible for a range of important functionalities and proceeds via the intermediacy of a six-membered palladacycle following a Pd(II)/Pd(IV) pathway. image</p>
10aC-H activation10aindoles10aPalladium10aRegioselective10aTrifluoroalkoxylation1 aVijaykumar, Muniyappa1 aGonnade, Rajesh, G.1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/palladium-catalyzed-regioselective-c4-h-fluoroalkoxylation-indoles-through-weak-chelation