02455nas a2200241   4500008004100000022001400041245012100055210006900176260000800245300001400253490000700267520164400274100001901918700001801937700001701955700001601972700001701988700001902005700001702024700002002041700002102061856013102082       2025                        eng d  a2040-336400aInvestigating the visible range photoresponse of an organic single-crystal analogue of the green fluorescent protein0 aInvestigating the visible range photoresponse of an organic sing  cAPR  a8614-86230 v173 a<p>
	The growing demand for lightweight, flexible, semi-transparent and low-cost photodetectors (PDs) in wearable electronics and optical communication systems has prompted studies to investigate organic materials as feasible alternatives to conventional inorganic PDs. However, modern organic PDs often face responsivity, detectivity, and photoresponse speed limitations, particularly in the visible range. Here, we present the photoresponse of an organic single-crystal analogue of the green fluorescent protein (GFP) chromophore photodetector, fabricated on a silicon nitride substrate. A significant increase in photocurrent was detected upon illumination with visible wavelengths (532 nm, 630 nm, and halogen light). A remarkably consistent and repeatable photoresponse was obtained during the ON and OFF illumination cycles. The device showed the dependence of photocurrent on the applied bias voltages. The measured photocurrent, responsivity, detectivity, rise time, decay time, noise equivalent power and external quantum efficiency are studied for different wavelengths. Strikingly, the fabricated device demonstrates excellent performance in the visible region compared to several conventional organic and inorganic PDs. The observed responsivity and detectivity values for the device are 98 mA W-1 and 7.94 x 108 Jones, respectively. Furthermore, the device also exhibits rapid photoresponse dynamics with a rise time of 180 ms and a decay time of 152 ms. The excellent photodetection features indicate that the single crystal GFP could serve as a versatile broadband material for future applications in optoelectronics.</p>
1 aVirole, Vishal1 aDabke, Niteen1 aVerma, Sahil1 aKumar, Ajay1 aPandya, Rinu1 aHusale, Sudhir1 aVanka, Kumar1 aGonnade, Rajesh1 aKanawade, Rajesh  uhttps://library.ncl.res.in/content/investigating-visible-range-photoresponse-organic-single-crystal-analogue-green-fluorescent03032nas a2200337   4500008004100000245018300041210006900224260000800293300001200301490000700313520189600320653002202216653001702238653001402255653002002269653002202289653002302311100001902334700002002353700001702373700001702390700001902407700002402426700001702450700001802467700002602485700001702511700001802528700001602546856013202562       2025                        eng d00aIsobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice0 aIsobavachalcone ameliorates Alzheimer disease pathology by autop  cMAR  a15253640 v163 a<p>
	Background and Aim Alzheimer's disease (AD) progresses with A beta plaque deposition and neuroinflammation. Given the complexity of AD pathology, single-target therapies have frequently failed in clinical trials. We hypothesized that a multitarget approach could yield better therapeutic outcomes. To this end, we identified isobavachalcone (IBC), a natural compound with dual pharmacological activity in reducing A beta plaques and neuroinflammation.Experimental Procedure Primary astrocytes were isolated from 3 to 4 days old C57BL/6J mice pups for in-vitro assays, while in-vivo studies were conducted on 5x-FAD mice. Protein alterations were evaluated using ELISA, western blotting, immunocytochemistry, and immunohistochemistry. Behavioral analyses included the radial arm maze, open field, and rotarod tests. Data from all in vitro and in vivo experiments were analyzed by using one-way ANOVA and post-hoc Bonferroni tests.Results In-vitro analyses in astrocytes demonstrated that IBC at 5 and 10 mu M concentrations induce AMPK phosphorylation through CAMKK2, promoting autophagy and inhibiting the NLRP3 inflammasome in primary astrocytes. IBC-treated astrocytes exhibited significant clearance of extracellular amyloid beta. Mechanistic studies highlighted autophagy as a key factor in reducing both NLRP3 inflammasome activity and A beta levels. Two months of treatment of 5x-FAD mice with IBC at 25 and 50 mg/kg significantly improved cognitive functions, as evidenced by enhanced memory and motor performance in behavioral tests. Subsequent brain tissue analysis revealed that IBC upregulated autophagic proteins to reduce the brain's amyloid beta levels, resulting in decreased expression of neuroinflammation markers.Conclusion IBC effectively ameliorates AD pathology through autophagy-mediated clearance of A beta and suppressing neuroinflammation in 5x-FAD mice.</p>
10aAlzheimer disease10aAmyloid beta10aAutophagy10aisobavachalcone10aneuroinflammation10aNLRP3 inflammasome1 aKour, Dilpreet1 aKhajuria, Parul1 aSharma, Kuhu1 aSharma, Alpa1 aSharma, Ankita1 aAli, Syed, Mudassir1 aWazir, Priya1 aRamajayan, P.1 aSawant, Sanghapal, D.1 aNandi, Utpal1 aAhmed, Zabeer1 aKumar, Ajay  uhttps://library.ncl.res.in/content/isobavachalcone-ameliorates-alzheimer-disease-pathology-autophagy-mediated-clearance-amyloid