01652nas a2200181   4500008004100000022001400041245011400055210006900169260000900238300001400247490000700261520097200268100002201240700003301262700002501295700002401320856012601344       2019                        eng d  a0022-326300aRu(II)-catalyzed C-H activation/alkylation of 3-formylbenzofurans with conjugated olefins: product divergence0 aRuIIcatalyzed CH activationalkylation of 3formylbenzofurans with  cMAY   a5056-50660 v843 a<p>Ru-catalyzed alkylation of 3-formylbenzofuran with acrylates and acrylamides has been described. Branched selectivity with unsubstituted or beta-substituted acrylates/ acrylamides and linear selectivity with alpha-substituted acrylates have been observed. However, in all of the cases, the intermediate alkylation products seem to undergo further reactions, either cycloannulation or deformylation, depending on the substrate employed. For example, with methyl acrylate, the intermediate branched alkylation product underwent cycloannulation with another molecule of methyl acrylate, resulting in a densely functionalized cyclohexene ring formation. On the other hand, in the case of N-monosubstituted acrylamides, the branched alkylation proceeded with intramolecular aldehyde-amide condensation, leading to pyridin-2-one ring annulation. However, with both methacrylate and crotonate, deformylation of the initially formed alkylation products was observed.</p>
1 aSrinivas, Kolluru1 aSiddiqui, Shaziyaparveen, K.1 aMudaliar, Jyothi, K.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/ruii-catalyzed-c-h-activationalkylation-3-formylbenzofurans-conjugated-olefins-product