01069nas a2200181   4500008004100000022001400041245009700055210006900152260000900221300001400230490000700244520042200251100002100673700002100694700001700715700002600732856012900758       2019                        eng d  a0022-326300aMetal-free regioselective cross dehydrogenative coupling of cyclic ethers and aryl carbonyls0 aMetalfree regioselective cross dehydrogenative coupling of cycli  cFEB   a2039-20470 v843 a<p>A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted alpha-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The regioselectivity of this CDC reaction was confirmed by density functional theory (DFT)-based calculations.</p>
1 aMane, Kishor, D.1 aMukherjee, Anagh1 aVanka, Kumar1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/metal-free-regioselective-cross-dehydrogenative-coupling-cyclic-ethers-and-aryl-carbonyls00995nas a2200169   4500008004100000022001400041245015500055210006900210260000800279300001400287490000700301520032400308100002100632700002200653700002600675856012400701       2019                        eng d  a1144-054600aVisible light mediated, metal and oxidant free highly efficient cross dehydrogenative coupling (CDC) reaction between quinoxalin-2(1H)-ones and ethers0 aVisible light mediated metal and oxidant free highly efficient c  cMAY  a7403-74080 v433 a<p>The efficient and metal free, white light mediated 3C alkylation of quinoxalin-2(1H)-ones via a cross dehydrogenative coupling reaction with cyclic ethers using eosin Y as a photocatalyst is described. This reaction has broad substrate scope and strong functional group tolerance with good to excellent yields.</p>
1 aMane, Kishor, D.1 aKamble, Rohit, B.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/visible-light-mediated-metal-and-oxidant-free-highly-efficient-cross-dehydrogenative01248nas a2200193   4500008004100000245012400041210006900165260000800234300001200242490000700254520053100261100002200792700002100814700002700835700002100862700001600883700002600899856012900925       2020                        eng d00aTi-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides0 aTisuperoxide catalyzed oxidative amidation of aldehydes with sac  cJAN  a724-7280 v103 a<p>A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.</p>
1 aKamble, Rohit, B.1 aMane, Kishor, D.1 aRupanawar, Bapurao, D.1 aKorekar, Pranjal1 aSudalai, A.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/ti-superoxide-catalyzed-oxidative-amidation-aldehydes-saccharin-nitrogen-source-synthesis00991nas a2200217   4500008004100000022001400041245006200055210005800117260000800175300001100183490000700194520034300201653002300544653001800567653001400585653001500599100002100614700002200635700002600657856009000683       2021                        eng d  a0040-403900aShort enantioselective total synthesis of (+)-tofacitinib0 aShort enantioselective total synthesis of tofacitinib  cMAR  a1528380 v673 a<p>An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved.</p>10aaminohydroxylation10aHydrogenation10aL-proline10apiperidone1 aMane, Kishor, D.1 aKamble, Rohit, B.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/short-enantioselective-total-synthesis-tofacitinib01695nas a2200181   4500008004100000022001400041245015200055210006900207260000800276300001400284490000700298520098500305100002101290700002301311700002301334700002601357856013001383       2022                        eng d  a0022-326300aAcetic acid-catalyzed regioselective C(sp(2))-H bond functionalization of indolizines: concomitant involvement of synthetic and theoretical studies0 aAcetic acidcatalyzed regioselective Csp2H bond functionalization  cAPR  a5097-51120 v873 a<p>
	An atom economical and environmentally benign protocol has been developed for the regioselective C(sp2)-H bondfunctionalization of indolizines. The acetic acid-catalyzed cross-coupling reaction proceeds under metal-free conditions, producing awide range of synthetically useful indolizine derivatives. The present protocol showed good functional group tolerance and broadsubstrate scope in good to excellent yields. Quantum mechanical investigation using density functional theory (DFT) has played acrucial role in understanding that acetic acid is the key player in determining the actual pathway as the catalyst and its ultrafastnature. Different pathways involving inter- and intramolecular proton transfer, with or without acetic acid, were investigated.Calculated results revealed that a proton shuttle mechanism is involved for the least energetic, most favorable acetic acid-catalyzedpathway. Furthermore, regioselectivity has also been explained theoretically.</p>
1 aMane, Kishor, D.1 aMukherjee, Anirban1 aDas, Gourab, Kanti1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/acetic-acid-catalyzed-regioselective-csp2-h-bond-functionalization-indolizines-concomitant01068nas a2200169   4500008004100000022001400041245015800055210006900213260000800282300001600290490000700306520038300313100002700696700002100723700002600744856012800770       2022                        eng d  a1144-054600aHypervalent-iodine-mediated oxidation followed by the acetoxylation/tosylation of alpha-substituted benzylamines to obtain alpha-acyloxy/tosyloxy ketones0 aHypervalentiodinemediated oxidation followed by the acetoxylatio  cSEP  a16832-168390 v463 a<p>
	An efficient and metal-free method has been developed for the sequential oxidation of alpha-alkylbenzylamines followed by acetoxylation or tosylation for the synthesis of alpha-acyloxy/tosyloxy ketones using hypervalent iodine(iii). The employment of a simple starting material, broad substrate scope and operational simplicity are the key features of this protocol.</p>
1 aRupanawar, Bapurao, D.1 aMane, Kishor, D.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/hypervalent-iodine-mediated-oxidation-followed-acetoxylationtosylation-alpha-substituted01178nas a2200229   4500008004100000022001400041245013200055210006900187260000800256300001500264490000700279520035900286653002900645653002500674653002600699653001500725653001700740100002100757700002100778700002600799856012300825       2022                        eng d  a2193-580700aMetal-free access to hindered N-alkyl sulfoximines via in-situ generated Aza-oxyallyl cations from functionalized alkyl bromide0 aMetalfree access to hindered Nalkyl sulfoximines via insitu gene  cJUL  ae2022002100 v113 a<p>
	Herein, we report a catalyst-free and mild synthetic method for the construction of hindered N-alkyl sulfoximines derivative. A wide range of hindered di-alkyl sulfoximines can be readily obtained from the reaction of alpha-bromo-hydroxamates with a variety of sulfoximines, including diaryl, aryl-alkyl, di-alkyl and heteroaryl sulfoximines.</p>
10aalpha-Bromo hydroxamates10aAza-oxyallyl cations10aDi-alkyl sulfoximines10ametal-free10aSulfoximines1 aMore, Satish, G.1 aMane, Kishor, D.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/metal-free-access-hindered-n-alkyl-sulfoximines-situ-generated-aza-oxyallyl-cations01409nas a2200241   4500008004100000022001400041245009000055210006900145260000900214300001100223490000800234520063300242653001900875653000800894653002100902653001900923653002100942100002300963700001800986700002101004700002301025856011901048       2022                        eng d  a0022-328X00aRegioselectivity in metalloradical catalyzed C-H bond activation: a theoretical study0 aRegioselectivity in metalloradical catalyzed CH bond activation   cJAN   a1221790 v9573 aPure quantum mechanical calculations were performed to find out the origin of regioselectivity under the metalloradical catalysis (MRC) by Co(II)-porphyrin, which showed regioselectivity is the inherent property of the aminyl radical generated from the sulfamoyl azide substrate. Different conformational analysis for the transition state from alpha-Co-III-aminyl radical to zeta-Co-III-alkyl radical formation have been studied to find out the most stable conformation for the preferable selectivity. The outcome of our study completely agrees with the reported experimental results. (C) 2021 Elsevier B.V. All rights reserved.10aC-H activation10aDFT10aMetalloporphyrin10aMetalloradical10aRegioselectivity1 aMukherjee, Anirban1 aSingh, Ritesh1 aMane, Kishor, D.1 aDas, Gourab, Kanti  uhttps://library.ncl.res.in/content/regioselectivity-metalloradical-catalyzed-c-h-bond-activation-theoretical-study01140nas a2200229   4500008004100000022001400041245011400055210006900169260000800238300001500246490000900261520038300270653001300653653000800666653000800674653001500682653001200697100002100709700002700730700002600757856012700783       2022                        eng d  a1434-193X00aVisible light-promoted, photocatalyst-free C(sp(2))-H bond functionalization of indolizines via EDA complexes0 aVisible lightpromoted photocatalystfree Csp2H bond functionaliza  cMAY  ae2022002610 v20223 a<p>
	The catalyst and additive-free, photo-driven cross dehydrogenative coupling (CDC) reaction initiated by electron donor-acceptor (EDA) complexes between electron rich indolizines and electron poor quinones has been demonstrated. This green transformation reveals the advantages of operational simplicity, mild reaction conditions and good functional group tolerances.</p>
10aBlue LED10aCDC10aEDA10aIndolizine10aQuinone1 aMane, Kishor, D.1 aRupanawar, Bapurao, D.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/visible-light-promoted-photocatalyst-free-csp2-h-bond-functionalization-indolizines-eda01169nas a2200229   4500008004100000022001400041245008600055210006900141260000800210300001100218490000800229520044500237653002500682653001100707653000900718653001500727100002100742700002100763700002100784700002600805856010800831       2023                        eng d  a0040-403900aSynthesis of 3 alkyl and 1,3-Bis(alkyl)indolizine amides from a-bromohydroxamates0 aSynthesis of 3 alkyl and 13Bisalkylindolizine amides from abromo  cMAR  a1543860 v1183 a<p>A simple and catalyst-free method has been developed for the synthesis of hindered indolizine amide derivatives from functionalized alkyl bromides. The reaction of a variety of indolizine derivatives with azaoxyallyl cations generated in situ from a-bromoamides afforded a wide range of synthetically important mono- and di-alkylated indolizine amide derivatives in good to excellent yields.@2023 Elsevier Ltd. All rights reserved.</p>
10aa -Bromohydroxamates10aAmides10aHFIP10aIndolizine1 aMane, Kishor, D.1 aBagwe, Sagar, S.1 aMore, Satish, G.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/synthesis-3-alkyl-and-13-bisalkylindolizine-amides-bromohydroxamates