01019nas a2200169   4500008004100000022001500041245011200056210006900168260000800237300001600245490000600261520039400267100001900661700001900680700002100699856012900720       2014                        eng d  a 2046-206900aConcise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM0 aConcise synthetic approach toward tamiflu oseltamivir phosphate   cFEB  a11417-114190 v43 aA synthesis of oseltamivir (Tamiflu) was achieved starting from D-mannitol. A unique feature of the synthetic route is that an acyclic precursor was constructed, which was then cyclized in an intramolecular aldol reaction to form the Tamiflu skeleton. Throughout the synthesis, well-established, highly efficient reactions were employed, and no protection/deprotection sequence was needed.1 aChavan, S., P.1 aChavan, P., N.1 aKhairnar, L., B.  uhttps://library.ncl.res.in/content/concise-synthetic-approach-toward-tamiflu-oseltamivir-phosphate-cis-aziridine-key-synthon