01715nas a2200169   4500008004100000022001400041245014000055210006900195260000900264300001200273490000800285520105500293100002401348700002001372700002401392856012901416       2015                        eng d  a0144-861700aSynthesis, characterization of thiolated karaya gum and evaluation of effect of pH on its mucoadhesive and sustained release properties0 aSynthesis characterization of thiolated karaya gum and evaluatio  cOCT   a183-1900 v1303 a<p>Present study aims at synthesis and characterization of thiolated gum karaya by reacting karaya gum with 80% thioglycolic acid resulting in esterification and immobilization of thiol groups on polymeric backbone. Immobilized thiol groups were found to be 5.026 mM/g determined by Ellman's method. It was characterized by FTIR, DSC and XRD. Directly compressible tablets prepared using thiolated gum displayed more disintegration time, swelling and mucoadhesion with increase in pH of medium simulating gastric and intestinal environment than plain gum. Controlled drug release for more than 24h by Fickian diffusion following Korsemeyer-Peppas model was observed with Metoprolol Succinate as a model drug as compared to plain gum which released more than 90% of the drug within 2 h. Synthesized thiomer showed no cytotoxicity determined using HepG2 cell line. According to these results, thiolated gum karaya seems to be promising excipient for the development of mucoadhesive drug delivery systems. (C) 2015 Elsevier Ltd. All rights reserved.</p>1 aBahulkar, Swati, S.1 aMunot, Neha, M.1 aSurwase, Sachin, S.  uhttps://library.ncl.res.in/content/synthesis-characterization-thiolated-karaya-gum-and-evaluation-effect-ph-its-mucoadhesive