01460nas a2200169   4500008004100000245013800041210006900179260000800248300001400256490000700270520082000277100001501097700001501112700001801127700001601145856012901161       2018                        eng d00aSynthesis and antitumor activity evaluation of 2-aminothiazoles appended 5-methylisoxazoline and pyridine-piperazine hybrid molecules0 aSynthesis and antitumor activity evaluation of 2aminothiazoles a  cNOV  a1070-10770 v153 aA highly efficient and milder protocol for the syntheses of novel series of 2-aminothiazoles bearing 5-methylisoxazoline and pyridine-piperazine hybrid molecules has been developed. The target compounds 13a-e were screened for their in vitro cytotoxicity activity against various tumor cell lines including MCF-7 (human breast adenocarcinoma), HCT-116 (colorectal carcinoma), Jurkat (human T-cell leukemia) and THP-1 (human acute monocytic leukemia). The bioactive assay showed that the most of the new compounds exhibited promising results in comparison with the parental Sunitinib. The synthesized compounds could well be used in the future as lead anticancer drugs in drug development studies. The synthesized compounds were fully characterized by IR,1 H NMR,13 C NMR, elemental analysis and mass spectral data. 1 aSuresh, G.1 aNadh, R.V.1 aSrinivasu, N.1 aYennity, D.  uhttps://library.ncl.res.in/content/synthesis-and-antitumor-activity-evaluation-2-aminothiazoles-appended-5-methylisoxazoline