01150nas a2200217 4500008004100000022001400041245013000055210006900185260000900254300001200263490000700275520036900282100002200651700002000673700002700693700001900720700002200739700001800761700002100779856013200800 2019 eng d a1523-706000aGold(I)-catalyzed hydroxy group assisted C(sp(2))-H alkylation of enaminones with diazo compounds to access 3-alkyl chromones0 aGoldIcatalyzed hydroxy group assisted Csp2H alkylation of enamin cJAN  a335-3390 v213 a

A strategy for expedient synthesis of 3-substituted chromones from easily available o-hydroxyarylenaminones and diazo compounds has been developed. Carefully conducted experimental and computational studies led us to propose an uncommon mechanistic pathway involving the hydroxyl group assisted alkylation of enaminones with in situ generated gold carbenes.

1 aBagle, Pradip, N.1 aMane, Manoj, V.1 aSancheti, Shashank, P.1 aGade, Amol, B.1 aShaikh, Samir, R.1 aBaik, Mu-Hyun1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/goldi-catalyzed-hydroxy-group-assisted-csp2-h-alkylation-enaminones-diazo-compounds-access-301363nas a2200241 4500008004100000022001400041245011400055210006900169260000800238520051600246653002700762653001900789653001900808653001500827653002600842100002700868700002200895700001500917700001800932700002200950700002100972856012800993 2019 eng d a1861-472800aOrtho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox relay catalysis0 aOrthooxygenative 12difunctionalization of diarylalkynes under me cOCT3 a

Reported herein is an ortho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox catalysis to access highly functionalized 2-(2-hydroxyaryl)-2-alkoxy-1-arylethan-1-ones. Detailed mechanistic studies suggested a relay process, initiating with gold-catalyzed hydroalkoxylation of alkynes, to generate enol-ether followed by a key formal [4+2]-cycloaddition reaction. The successful application of the present methodology was also shown for the synthesis of benzofurans.

10abinary catalyst system10aGold catalysis10aorganocatalyst10aphotoredox10asynthetic methodology1 aSancheti, Shashank, P.1 aAkram, Manjur, O.1 aRoy, Rupam1 aBedi, Vaibhav1 aKundu, Shubhankar1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/ortho-oxygenative-12-difunctionalization-diarylalkynes-under-merged-goldorganophotoredox01704nas a2200205 4500008004100000022001400041245009100055210006900146260000800215300001600223490000700239520100400246100002301250700002001273700002701293700002101320700002001341700002101361856011601382 2022 eng d a2041-652000aBQ-AurIPr: a redox-active anticancer Au(i) complex that induces immunogenic cell death0 aBQAurIPr a redoxactive anticancer Aui complex that induces immun cSEP a10779-107850 v133 a

Immunogenic Cell Death (ICD) is a unique cell death mechanism that kills cancer cells while rejuvenating the anticancer immunosurveillance, thereby benefiting the clinical outcomes of various immuno-chemotherapeutic regimens. Herein, we report development of a library of benzo[a]quinolizinium-based Au(i) complexes through an intramolecular amino-auration reaction of pyridino-alkynes. We tested 40 candidates and successfully identified BQ-AurIPr as a novel redox-active Au(i) complex with potent anticancer properties. BQ-AurIPr efficiently triggered generation of DAMPs - the hallmarks of ICD - and was superior in terms of efficiency compared to FDA-approved drugs known to induce ICD. BQ-AurIPr significantly increased immunogenicity of cancer cells enhancing their phagocytosis when co-cultured with immune cells. Our investigation reveals that BQ-AurIPr induces oxidative stress inside mitochondria leading to mitophagy, as the mechanism for immunogenic cell death in A549 cells.

1 aMule, Ravindra, D.1 aKumar, Akhilesh1 aSancheti, Shashank, P.1 aSenthilkumar, B.1 aKumar, Himanshu1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/bq-auripr-redox-active-anticancer-aui-complex-induces-immunogenic-cell-death01998nas a2200349 4500008004100000022001400041245022500055210006900280260000900349300001500358490000700373520077700380653002301157653001201180653001601192653002201208653002601230653001301256100002301269700001501292700002001307700001901327700001701346700002701363700002201390700002301412700002301435700001801458700002501476700002101501856012601522 2022 eng d a0947-653900aInterplay of anion-pi(+) and pi(+)-pi(+) interactions in novel pyrido[2,1-a]isoquinolinium-based aiegens - substituent- and counterion-dependent fluorescence modulation and applications in live cell mitochondrial imaging0 aInterplay of anionpi and pipi interactions in novel pyrido21aiso cJUL  ae2022006320 v283 a

Recently, the concept of anion-pi(+) interactions has witnessed unique applications in the field of AIEgen development. In this contribution, we disclose a consolidated study of a library of N-doped ionic AIEgens accessed through silver-mediated cyclization of pyridino-alkynes. A thorough photophysical, computational and crystallographic study has been conducted to rationalize the observed substituent- and counterion-dependent fluorescence properties of these luminogens. We further elucidate the prominent role of anion-pi(+) interactions, pi(+)-pi(+) interactions and other non-covalent interactions, in inhibiting the undesired ACQ effect. Finally, we have also demonstrated the application of selected AIEgens for imaging of mitochondria in live cells.

10a1-a]isoquinolinium10aAIEgens10aanion-pi(+)10acrystal structure10amitochondrial imaging10apyrido[21 aMule, Ravindra, D.1 aRoy, Rupam1 aMandal, Koushik1 aChopra, Deepak1 aDutta, Tanoy1 aSancheti, Shashank, P.1 aShinde, Popat, S.1 aBanerjee, Somsuvra1 aKoner, Apurba, Lal1 aBhowal, Rohit1 aSenthilkumar, Beeran1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/interplay-anion-pi-and-pi-pi-interactions-novel-pyrido21-aisoquinolinium-based-aiegens