02271nas a2200265   4500008004100000022001400041245010900055210006900164260000800233300001000241490000700251520135700258653003501615653001701650653001701667653003501684653000901719100002701728700003101755700002101786700002401807700002301831700002501854856012601879       2020                        eng d  a0268-260500aAnthrone-spirolactam and quinoline hybrid based sensor for selective fluorescent detection of Fe(3+)ions0 aAnthronespirolactam and quinoline hybrid based sensor for select  cOCT  ae58670 v343 a<p>The synthesis of a novel, and highly selective Fe(3+)ion sensor based on anthrone-spirolactam and its quinoline hybrid ligand is reported. The designed ligand displayed selective detection of Fe(3+)ions with enhanced fluorescence emission. The complexation of Fe(3+)ion led to a red shift of 32 nm from 420 nm to 452 nm, and a several fold increase in intensity with fluorescent green emission. The complexation (detection) of Fe(3+)ions with ligand resulted in chelation enhanced fluorescence and intramolecular charge transfer through the inhibition of C=N isomerization. This hybrid sensor shows high sensitivity and selectivity, spontaneous response, and works on a wide pH range a minimum detection limit of 6.83 x 10(-8)M. Importantly, the sensor works through the fluorescence turn-on mechanism that overcomes the paramagnetic effect of Fe(3+)ions. The binding mechanism between the ligand and the Fe(3+)ions was established from the Job's plot method, optical studies, Fourier transfor infrared spectroscopy, NMR titration, fluorescence life-time studies, and density functional theory optimization. The sensor displayed excellent results in the quantification of Fe(3+)ions from real water samples. Furthermore, due to its biocompatibility nature, fluorescent spotting of Fe(3+)ions in live cells revealed its bioimaging applications.</p>
10aanthrone-spirolactam-quinoline10aCell imaging10afluorescence10aintramolecular charge transfer10airon1 aDarole, Ratanamala, S.1 aLeslee, Denzil, Britto Chr1 aMukherjee, Anagh1 aGonnade, Rajesh, G.1 aKaruppannan, Sekar1 aSenthilkumar, Beeran  uhttps://library.ncl.res.in/content/anthrone-spirolactam-and-quinoline-hybrid-based-sensor-selective-fluorescent-detection01307nas a2200181   4500008004100000022001400041245011700055210006900172260000800241300001400249490000700263520063800270100001700908700001800925700002600943700002500969856013100994       2025                        eng d  a1477-052000aAccessing polysubstituted 2-cyclopentenones via base-mediated annulation of β-keto esters and phenacyl bromides0 aAccessing polysubstituted 2cyclopentenones via basemediated annu  cMAY  a4519-45240 v233 a<p>
	A transition metal-free method is demonstrated for the synthesis of polysubstituted 2-cyclopentenone compounds, which involves the direct annulation of phenacyl bromide with beta-keto esters in a single step. This process proceeds through a base-mediated SN2 nucleophilic substitution, followed by an intramolecular aldol condensation, resulting in the formation of three C-C bonds and one ring in a cascade manner. The experimental results achieved a record high yield of highly substituted diverse 2-cyclopentenone analogues, which exhibit very good structural resemblance to biologically significant natural compounds.</p>
1 aKumar, Mohit1 aPaul, Vincent1 aGamidi, Rama, Krishna1 aSenthilkumar, Beeran  uhttps://library.ncl.res.in/content/accessing-polysubstituted-2-cyclopentenones-base-mediated-annulation-%CE%B2-keto-esters-and