02837nas a2200337   4500008004100000022001400041245018300055210006900238260000900307300001200316490000800328520165900336653001501995653002602010653002102036653003402057653002402091100002102115700001202136700002302148700002202171700001802193700002802211700002402239700002302263700002402286700001902310700002302329700002202352856012502374       2018                        eng d  a0013-468600aPorous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 2: Application to the analysis of calcitonin containing pharmaceutical formulation0 aPorous reduced graphene oxide modified electrodes for the analys  cMAR   a364-3720 v2663 a<p>In part 1 (A. Vasilescu et al., Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 1: Lysozyme aggregation at pH 2 and 7.4 Electrochem. Acta, 254 (2017) 375 -383) we proposed porous reduced graphene oxide coated glassy carbon electrode (GC/prGO) in combination with differential pulse voltammetry as a new analytical tool for aggregation studies of proteins. Lysozyme was used as a model to follow its aggregation by electrochemical means at pH 2 and pH 7.4, leading to the formation of amyloid and amorphous aggregates, respectively. Part 2 of this work widens the scope of this approach by investigating a biopharmaceutical product, as the aggregation of peptide based drugs affects their therapeutic activity and can induce allergic reactions in patients. The salmon polypeptide calcitonin (sCT) was chosen as an example of a bioactive peptide with limited pharmaceutical potential due to a tendency to form cytotoxic aggregates and amyloid fibrils. For practical applications, screen printed electrodes (SPE) and flexible electrodes (FE) modified with polydiallyldimethylammonium (PDDA) and prGO by using the layer-by-layer deposition technique have been developed for the detection of sCT. The results indicate that these electrodes can differentiate between formation of amyloid aggregates of calcitonin (2 mg mL(-1)) in citrate buffer to no aggregation in acetate buffer. It was further demonstrated that these electrodes are able to analyze a pharmaceutical drug product of low potency, Miacalcic (8.3 mu g mL(-1)), where no aggregation was observed. (C) 2018 Elsevier Ltd. All rights reserved.</p>10aCalcitonin10aDisposable electrodes10aElectrochemistry10aPorous reduced graphene oxide10aProtein aggregation1 aVasilescu, Alina1 aYe, Ran1 aBoulahneche, Samia1 aLamraoui, Sabrina1 aJijie, Roxana1 aMedjram, Mohamed, Salah1 aGaspar, Szilveszter1 aSingh, Santosh, K.1 aKurungot, Sreekumar1 aMelinte, Sorin1 aBoukherroub, Rabah1 aSzunerits, Sabine  uhttps://library.ncl.res.in/content/porous-reduced-graphene-oxide-modified-electrodes-analysis-protein-aggregation-part-202153nas a2200253   4500008004100000022001400041245013200055210006900187260000800256300001500264490000600279520124500285653003001530653002101560653002601581653003201607653003001639100001701669700002201686700001401708700002401722700002301746856013001769       2022                        eng d  a2365-654900aSingle-step synthesis of exfoliated Ti3C2Tx MXene through NaBF4/HCl etching as electrode material for asymmetric supercapacitor0 aSinglestep synthesis of exfoliated Ti3C2Tx MXene through NaBF4HC  cMAY  ae2022011660 v73 a<p>
	Two-dimensional Ti3C2Tx MXene, derived from the parent Ti3AlC2 phase, is considered a promising electrode material for electrochemical energy storage applications. Ti3C2Tx MXene synthesis methods often employ concentrated hydrofluoric acid (HF), which is harsh, corrosive, and hazardous to the environment. Herein, we report the preparation of Ti3C2Tx MXene following a new synthetic route under a mild reaction condition comprising an aqueous solution of NaBF4 and HCl. This etching environment at a moderate temperature of 130 degrees C effectively removes the Al layer of the Ti3AlC2 precursor, assisted by the in situ formed HF in the reaction medium. Electron microscopy images of the as-prepared Ti3C2Tx (MX-130) reveal a partially exfoliated nanosheet-like morphology. The material displays a specific capacitance of 262 F g(-1) (three-electrode assembly, 1 A g(-1), -0.85 to -0.25 V vs. Hg/Hg2SO4) in 1 M H2SO4 electrolyte. The achieved specific capacitance is superior to that of Ti3C2Tx prepared via the common HF-treatment (25 F g(-1)). Additionally, the potential application of the optimized MXene as a negative electrode material is demonstrated in a quasi-solid-state RuO2|MX-130 asymmetric supercapacitor device.</p>
10aasymmetric supercapacitor10aElectrochemistry10aFluoride salt etchant10aLayered electrode materials10aTransition metal carbides1 aGhosh, Meena1 aSzunerits, Sabine1 aCao, Ning1 aKurungot, Sreekumar1 aBoukherroub, Rabah  uhttps://library.ncl.res.in/content/single-step-synthesis-exfoliated-ti3c2tx-mxene-through-nabf4hcl-etching-electrode-material