01167nas a2200241   4500008004100000022001500041245009200056210006900148260000800217300001400225490000700239520040200246100001700648700002100665700001900686700001900705700001900724700001600743700001600759700001600775700001600791856011800807       2018                        eng d  a 0887-624X00a Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers0 aBalancing antimicrobial performance with hemocompatibility in am  cNOV  a2391-23960 v563 aThis work establishes amphiphilic polymethacrylates as new antimicrobial candidates that can be synthesized through a combination of controlled free radical polymerization and sequential postpolymerization modification protocols. When conjugated with a polyethylene glycol segment, the block copolymers exhibit a balanced performance between high antibacterial activity and high hemocompatibility.1 aZhu, Zhiyuan1 aJeong, Gookyeong1 aKim, Seung-Jin1 aGadwal, Ikhlas1 aChoe, Youngson1 aBang, Joona1 aOh, Min-Kyu1 aKhan, Anzar1 aRao, Jingyi  uhttps://library.ncl.res.in/content/balancing-antimicrobial-performance-hemocompatibility-amphiphilic-homopolymers02595nas a2200241   4500008004100000022001400041245016600055210006900221260000900290300001200299490000700311520166800318653004801986653002702034653003802061653002102099653001602120100001902136700002802155700002102183700002602204856012302230       2019                        eng d  a0887-624X00aNew approach for the synthesis of miktoarm star polymers through a combination of thiol-epoxy ``click'' chemistry and ATRP/Ring-opening polymerization techniques0 aNew approach for the synthesis of miktoarm star polymers through  cJAN   a146-1560 v573 a<p>A new approach was developed for synthesis of certain A(3)B(3)-type of double hydrophilic or amphiphilic miktoarm star polymers using a combination of ``grafting onto'' and ``grafting from'' methods. To achieve the synthesis of desired miktoarm star polymers, acetyl protected poly(ethylene glycol) (PEG) thiols (M-n = 550 and 2000 g mol(-1)) were utilized to generate A(3)-type of homoarm star polymers through an in situ protective group removal and a subsequent thiol-epoxy ``click'' reaction with a tris-epoxide core viz. 1,1,1-tris(4-hydroxyphenyl)ethane triglycidyl ether. The secondary hydroxyl groups generated adjacent to the core upon the thiol-epoxy reaction were esterified with alpha-bromoisobutyryl bromide to install atom transfer radical polymerization (ATRP) initiating sites. ATRP of N-isopropylacrylamide (NIPAM) using the three-arm star PEG polymer fitted with ATRP initiating sites adjacent to the core afforded A(3)B(3)-type of double hydrophilic (PEG)(3)[poly(N-isopropylacrylamide)] (PNIPAM)(3) miktoarm star polymers. Furthermore, the generated hydroxyl groups were directly used as initiator for ring-opening polymerization of epsilon-caprolactone to prepare A(3)B(3)-type of amphiphilic (PEG)(3)[poly(epsilon-caprolactone)](3) miktoarm star polymers. The double hydrophilic (PEG)(3)(PNIPAM)(3) miktoarm star polymers showed lower critical solution temperature around 34 degrees C. The preliminary transmission electron microscopy analysis indicated formation of self-assembly of (PEG)(3)(PNIPAM)(3) miktoarm star polymer in aqueous solution. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 146-156</p>10aAtom transfer radical polymerization (ATRP)10amiktoarm star polymers10aring-opening polymerization (ROP)10athermoresponsive10athiol-epoxy1 aGadwal, Ikhlas1 aWadgaonkar, Prakash, P.1 aIchake, Amol, B.1 aMane, Shivshankar, R.  uhttps://library.ncl.res.in/content/new-approach-synthesis-miktoarm-star-polymers-through-combination-thiol-epoxy-click