01500nas a2200193   4500008004100000022001400041245012600055210006900181260011000250300001800360490000600378520067500384100002401059700002501083700002101108700002501129700002401154856012801178       2015                        eng d  a2046-206900aAmmonium persulfate activated DMSO as a one-carbon synthon for the synthesis of methylenebisamides and other applications0 aAmmonium persulfate activated DMSO as a onecarbon synthon for th  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a101641-1016460 v53 a<p>Activation of DMSO to work as an economical and environmentally benign one-carbon synthon has been achieved by using a bench-top reagent ammonium persulfate for general and efficient access to symmetrical methylenebisamides from primary amides. This methodology was used to achieve a three-component Mannich reaction using acetophenone, saccharin and DMSO to furnish a beta-amino ketone. It also provided a metal-free synthesis of thiadiazole and bis(phenyl)methane. Effectively, this method uses DMSO as a safer surrogate to formaldehyde. A mechanism for methylenebisamide formation involving radical intermediates has been proposed based on mechanistic studies.</p>1 aMahajan, Pankaj, S.1 aTanpure, Subhash, D.1 aMore, Namita, A.1 aGajbhiye, Jayant, M.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/ammonium-persulfate-activated-dmso-one-carbon-synthon-synthesis-methylenebisamides-and-001361nas a2200229   4500008004100000022001400041245013100055210006900186260008600255300001400341490000700355520048000362653001300842653001100855653002400866653002100890653001600911100002700927700002500954700002400979856012801003       2015                        eng d  a1860-539700aRadical-mediated dehydrative preparation of cyclic imides using (NH4)(2)S2O8-DMSO: application to the synthesis of vernakalant0 aRadicalmediated dehydrative preparation of cyclic imides using N  aTRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANYbBEILSTEIN-INSTITUTcJUN  a1008-10160 v113 a<p>Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.</p>10aAPS-DMSO10aimides10apractical synthesis10aradical-mediated10avernakalant1 aGarad, Dnyaneshwar, N.1 aTanpure, Subhash, D.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/radical-mediated-dehydrative-preparation-cyclic-imides-using-nh42s2o8-dmso-application-001328nas a2200181   4500008004100000022001400041245015200055210006900207260007100276300001400347490000700361520055800368100002400926700002100950700002500971700002400996856012601020       2016                        eng d  a1523-706000aRadical beckmann rearrangement and its application in the formal total synthesis of antimalarial natural product isocryptolepine via C-H activation0 aRadical beckmann rearrangement and its application in the formal  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL  a3450-34530 v183 a<p>The Beckmann rearrangement of ketoximes, mediated by ammonium persulfate-dimethyl sulfoxide as a reagent, has been achieved under neutral conditions. Based on the radical trapping and O-18-labeling experiments, the transformation follows a mechanism involving a radical pathway. The scope and generality of the developed protocol has been demonstrated by 19 examples. The developed protocol and Pd-catalyzed intramolecular double C-H activation were used as key steps in the formal total synthesis of antimalarial natural product isocryptolepine.</p>1 aMahajan, Pankaj, S.1 aHumne, Vivek, T.1 aTanpure, Subhash, D.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/radical-beckmann-rearrangement-and-its-application-formal-total-synthesis-antimalarial