01162nas a2200193   4500008004100000245007600041210006900117260000800186300001400194490000700208520049700215100002300712700001900735700001500754700002400769700003000793700003700823856010800860       2018                        eng d00aLipase catalyzed synthesis of antimicrobial andrographolide derivatives0 aLipase catalyzed synthesis of antimicrobial andrographolide deri  cJUN  a1134-11410 v183 aIn this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.1 aPatil, Harshal, S.1 aJadhav, Dipesh1 aPaul, Ajay1 aMulani, Fayaj, Alam1 aKaregaonkar, Shrikant, J.1 aThulasiram, Hirekodathakallu, V.  uhttps://library.ncl.res.in/content/lipase-catalyzed-synthesis-antimicrobial-andrographolide-derivatives01797nas a2200181   4500008004100000245004600041210004600087260000800133300001200141490000600153520123400159100002801393700001601421700002401437700003701461700003601498856008101534       2021                        eng d00aNeem derivatives inhibits tau aggregation0 aNeem derivatives inhibits tau aggregation  cJAN  a169-1780 v33 aTau is a phosphoprotein with natively unfolded conformation that functions to stabilize microtubules in axons. Alzheimer's disease pathology triggers several modifications in tau, which causes it to lose its affinity towards microtubule, thus, leading to microtubule disassembly and loss of axonal integrity. This elicit accumulation of tau as paired helical filaments is followed by stable neurofibrillary tangles formation. A large number of small molecules have been isolated from Azadirachta indica with varied medicinal applications. The intermediate and final limonoids, nimbin and salannin respectively, isolated from Azadirachta indica, were screened against tau aggregation. ThS and ANS fluorescence assay showed the role of intermediate and final limonoids in preventing heparin induced cross-β sheet formation and also decreased hydrophobicity, which are characteristic nature of tau aggregation. Transmission electron microscopy studies revealed that limonoids restricted the aggregation of tau to fibrils; in turn, limonoids led to the formation of short and fragile aggregates. Both the limonoids were non-toxic to HEK293T cells thus, substantiating limonoids as a potential lead in overcoming Alzheimer's disease.1 aNalini, Gorantla, Vijay1 aDas, Rashmi1 aMulani, Fayaj, Alam1 aThulasiram, Hirekodathakallu, V.1 aChinnathambi, Subashchandrabose  uhttps://library.ncl.res.in/content/neem-derivatives-inhibits-tau-aggregation