01313nas a2200193   4500008004100000022001400041245014700055210006900202260000800271300001400279490000700293520060200300100002300902700001600925700002000941700002000961700002200981856011601003       2018                        eng d  a1523-706000aEnantioselective N-heterocyclic carbene-catalyzed cascade reaction for the synthesis of pyrroloquinolines via N-H functionalization of indoles0 aEnantioselective Nheterocyclic carbenecatalyzed cascade reaction  cNOV  a6998-70020 v203 aFunctionalization of the indole N-H bond for enantioselective synthesis of biologically important pyrroloquinoline derivatives has been reported under oxidative N-heterocyclic carbene catalysis conditions. The interception of catalytically generated chiral alpha,beta-unsaturated acylazoliums with the indole derivatives proceeds in an aza-Michael/Michael/lactonization sequence to deliver the pyrroloquinoline derivatives in good yields, diastereoselectivities, and enantioselectivities. The simultaneous enhancement of reactivity and selectivity observed in polar aprotic solvents is noteworthy.1 aMukherjee, Subrata1 aShee, Sayan1 aPoisson, Thomas1 aBesset, Tatiana1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/enantioselective-n-heterocyclic-carbene-catalyzed-cascade-reaction-synthesis01242nas a2200205   4500008004100000022001400041245007900055210006900134260000800203300001400211490000700225520057200232100001800804700001700822700002400839700002200863700002000885700002000905856011100925       2018                        eng d  a1523-706000aN-Heterocyclic carbene-catalyzed synthesis of alpha-trifluoromethyl esters0 aNHeterocyclic carbenecatalyzed synthesis of alphatrifluoromethyl  cJUL  a3897-39010 v203 a<p>The N-heterocyclic carbene (NHC)-catalyzed trifluoromethylation of alpha-chloro aldehydes was developed, allowing straightforward access to valuable alpha-trifluoromethyl ester derivatives. The unique combination of an electrophilic trifluoromethylation reagent with NHC catalysis was the key for the functionalization of a broad range of alpha-chloro aldehydes, and the products are formed in moderate to good yields. Investigations of the enantioselective version of this reaction afforded the enantioenriched products in moderate yields with good ee values.</p>1 aGelat, Fabien1 aPatra, Atanu1 aPannecoucke, Xavier1 aBiju, Akkattu, T.1 aPoisson, Thomas1 aBesset, Tatiana  uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-synthesis-alpha-trifluoromethyl-esters01175nas a2200205   4500008004100000022001300041245008000054210006900134260000800203300001600211490000700227520050800234100001700742700001800759700002400777700002000801700002000821700002200841856010600863       2018                        eng d  a1523706000aSynthesis of 4-difluoromethylquinolines by NHC-catalyzed umpolung of imines0 aSynthesis of 4difluoromethylquinolines by NHCcatalyzed umpolung   cJAN  a1086–10890 v203 aThe N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines for the synthesis of 4-difluoromethylquinoline derivatives is reported. In the presence of NHCs, the intramolecular cyclization of aldimines bearing a moderately electron-poor double bond due to the presence of the −CF3 group likely proceeds via the intermediacy of the aza-Breslow intermediate. The key to the success of this aza-Stetter type transformation is the NHC generated from the bicyclic triazolium salt using DBU as the base.1 aPatra, Atanu1 aGelat, Fabien1 aPannecoucke, Xavier1 aPoisson, Thomas1 aBesset, Tatiana1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/synthesis-4-difluoromethylquinolines-nhc-catalyzed-umpolung-imines