01777nas a2200217   4500008004100000022001300041245013800054210006900192260000800261300001400269490000600283520098100289100002501270700002201295700002101317700002501338700002201363700003101385700002401416856011901440       2018                        eng d  a2365654900aSynthesis of novel alpha-aminophosphonate derivatives, biological evaluation as potent antiproliferative agents and molecular docking0 aSynthesis of novel alphaaminophosphonate derivatives biological   cMAY  a5552-55580 v33 a<p>A series of novel fluorine containing α‐aminophosphonate derivatives (4 a–4 q) were synthesized in excellent yield and high purity. All these novel Fluorinated α‐aminophosphonate compounds were screened for antiproliferative and apoptosis activity on human non small cell lung carcinoma cells (A549) and human skin melanoma cells (SK‐MEL‐2). Compounds 4 a, 4 b, 4 c, 4 f, 4 i, 4 j and 4 m were found to be more active antiproliferative agent against A549 and SK‐MEL‐2 cells with IC50 value 0.22 to 1.25 μM. Molecular docking study related to binding affinity and binding mode analysis showed that synthesized compounds had potential to inhibit human Topoisomerase IIa enzyme system. Flow cytometric study showed some of these derivatives also induced cell apoptosis and arrest cell cycle at G1 and at G2/M phase. Overall, this study provides future perspective of lead candidate for the future anticancer drug discovery initiatives.</p>1 aDeshmukh, Satish, U.1 aKharat, Kiran, R.1 aYadav, Ashok, R.1 aShisodia, Suresh, U.1 aDamale, Manoj, G.1 aSangshetti, Jaiprakash, N.1 aPawar, Rajendra, P.  uhttps://library.ncl.res.in/content/synthesis-novel-alpha-aminophosphonate-derivatives-biological-evaluation-potent