02245nas a2200253   4500008004100000022001400041245007200055210006900127260000800196300000800204490000800212520141600220653002001636653002001656653003601676653002301712653005101735100001901786700001801805700001701823700002601840700002801866856009701894       2020                        eng d  a0981-942800aStructure and regulation of SWEET transporters in plants: an update0 aStructure and regulation of SWEET transporters in plants an upda  cNOV  a1-60 v1563 a<p>Sugar will eventually be exported transporters (SWEETs), a novel family of sugar transporters found in both eukaryotes and prokaryotes, facilitate sugar flux across the cell membrane. Although these transporters were first discovered in plants, their homologs have been reported in different organisms. SWEETs have critical roles in various developmental processes, including phloem loading, nectar secretion, and pathogen nutrition. The structure of bacterial homologs, called SemiSWEETs, has been well studied thus far. Here, we provide an overview of SWEET protein structure and dynamic function by analyzing the solved crystal structures and predicted models that are available for a few SWEETs in a monocot plant (rice) and dicot plant (Arabidopsis thaliana). Despite the advancement in structure-related studies, the regulation of SWEETs remains unknown. In light of reported regulatory mechanisms of a few other sugar transporters, we propose the regulation of SWEETs at the post-translational level. We then enumerate the potential post-translational modification sites in SWEETs using computational tools. Overall, in this review, we critically analyze SWEET protein structure in plants to predict the post-translational regulation of SWEETs. Such findings have a direct bearing on plant nutrition and defense and targeting the regulation at these levels will be important in crop improvement.</p>
10aoligomerization10aPhosphorylation10aPost-translational modification10aSugar transporters10aSugar will eventually be exported transporters1 aAnjali, Anjali1 aFatima, Urooj1 aManu, M., S.1 aRamasamy, Sureshkumar1 aSenthil-Kumar, Muthappa  uhttps://library.ncl.res.in/content/structure-and-regulation-sweet-transporters-plants-update