02255nas a2200265 4500008004100000022001400041245013400055210006900189260009500258300001200353490000800365520121200373653002101585653002401606653003501630653001901665653002301684100002501707700002401732700002801756700002501784700002601809700003001835856012401865 2011 eng d a0003-269700aCarbon nanotube-modified sodium dodecyl sulfate-polyacrylamide gel electrophoresis for molecular weight determination of proteins0 aCarbon nanotubemodified sodium dodecyl sulfatepolyacrylamide gel a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcFEB a230-2350 v4093 a

The effect of incorporating carbon nanotubes (CNTs) in the gel matrix on the electrophoretic mobility of proteins based on their molecular weight differences was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). More specifically, a reduction in standard deviation in the molecular weight calibration plots by 55% in the case of multiwalled carbon nanotubes (MWCNTs) and by 34% in the case of single-walled carbon nanotubes (SWCNTs) compared with that of pristine polyacrylamide gels was achieved after incorporating an insignificant amount of functionalized CNTs into the gel matrix. A mechanism based on a more uniform pore size distribution in CNT modified polyacrylamide gel matrix is proposed. Furthermore, the impact of SWCNTs and MWCNTs on the mobility of proteins in different molecular weight regimes at a given acrylamide concentration offers a tunable gel matrix in terms of the selection of molecular weight ranges of proteins. The robustness and excellent reproducibility of the CNT-PAGE protocol are expected to have a significant impact on the molecular weight determination of newly isolated proteins. (C) 2010 Elsevier Inc. All rights reserved.

10aCarbon nanotubes10aGel electrophoresis10aMolecular weight determination10aPolyacrylamide10aProtein separation1 aParthasarathy, Meera1 aDebgupta, Joyashish1 aKakade, Bhalchandra, A.1 aAnsary, Abu, Ayoobul1 aKhan, Mohammad, Islam1 aPillai, Vijayamohanan, K. uhttps://library.ncl.res.in/content/carbon-nanotube-modified-sodium-dodecyl-sulfate-polyacrylamide-gel-electrophoresis-001841nas a2200169 4500008004100000022001400041245013400055210006900189260011000258300001600368490000700384520107200391100002401463700002801487700003001515856012601545 2011 eng d a1463-907600aCompetitive wetting of acetonitrile and dichloromethane in comparison to that of water on functionalized carbon nanotube surfaces0 aCompetitive wetting of acetonitrile and dichloromethane in compa aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL a14668-146740 v133 a

Differential wetting of pristine and ozonized carbon nanotubes has been studied using solvents like acetonitrile and dichloromethane in comparison to the well-known wetting behavior of water. Based on their unique structural and physical properties, functionalized CNT substrates have been used due to the fact that independent variation in molecular as well as electronic properties could be controlled by understanding the wetting of these liquids on carbon nanotubes (CNTs), both pristine as well as ozone treated. The sensitivity of the wetting behavior with respect to molecular interactions has been investigated using contact angle measurements while Raman and XPS studies unravel the differential wetting behavior. Charge-transfer between adsorbed molecules and CNTs has been identified to play a crucial role in determining the interfacial energies of these two liquids, especially in the case of acetonitrile. Ozone treatment has been observed to affect the surface properties of pristine CNTs along with a concomitant change in the wetting dynamics.

1 aDebgupta, Joyashish1 aKakade, Bhalchandra, A.1 aPillai, Vijayamohanan, K. uhttps://library.ncl.res.in/content/competitive-wetting-acetonitrile-and-dichloromethane-comparison-water-functionalized-001861nas a2200181 4500008004100000022001400041245013300055210006900188260009000257300000900347490000600356520108400362100002901446700002401475700003001499700002501529856012501554 2014 eng d a2045-232200aC@SiNW/TiO2 core-shell nanoarrays with sandwiched carbon passivation layer as high efficiency photoelectrode for water splitting0 aCSiNWTiO2 coreshell nanoarrays with sandwiched carbon passivatio aMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLANDbNATURE PUBLISHING GROUPcMAY a48970 v43 a

One-dimensional heterostructure nanoarrays are efficiently promising as high performance electrodes for photo electrochemical (PEC) water splitting applications, wherein it is highly desirable for the electrode to have a broad light absorption, efficient charge separation and redox properties as well as defect free surface with high area suitable for fast interfacial charge transfer. We present highly active and unique photoelectrode for solar H-2 production, consisting of silicon nanowires (SiNWs)/TiO2 core-shell structures. SiNWs are passivated to reduce defect sites and protected against oxidation in air or water by forming very thin carbon layer sandwiched between SiNW and TiO2 surfaces. This carbon layer decreases recombination rates and also enhances the interfacial charge transfer between the silicon and TiO2. A systematic investigation of the role of SiNW length and TiO2 thickness on photocurrent reveals enhanced photocurrent density up to 5.97 mA/cm(2) at 1.0 V vs. NHE by using C@SiNW/TiO2 nanoarrays with photo electrochemical efficiency of 1.17%.

1 aDevarapalli, Rami, Reddy1 aDebgupta, Joyashish1 aPillai, Vijayamohanan, K.1 aShelke, Manjusha, V. uhttps://library.ncl.res.in/content/csinwtio2-core-shell-nanoarrays-sandwiched-carbon-passivation-layer-high-efficiency-000694nas a2200169 4500008004100000022001400041245009600055210006900151260005700220300001200277490000600289100002400295700002400319700003000343700002500373856012600398 2015 eng d a1868-252900aCo3O4 nanorods-efficient non-noble metal electrocatalyst for oxygen evolution at neutral pH0 aCo3O4 nanorodsefficient nonnoble metal electrocatalyst for oxyge a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcJUL a331-3400 v61 aRamsundar, Rani, M.1 aDebgupta, Joyashish1 aPillai, Vijayamohanan, K.1 aJoy, Pattayil, Alias uhttps://library.ncl.res.in/content/co3o4-nanorods-efficient-non-noble-metal-electrocatalyst-oxygen-evolution-neutral-ph-003043nas a2200229 4500008004100000022001400041245016600055210006900221260011000290300001400400490000600414520208700420100002302507700003102530700002402561700001702585700001602602700002402618700002602642700002202668856012302690 2016 eng d a2046-206900aComparative study of dG affinity vs. DNA methylation modulating properties of side chain derivatives of procainamide: insight into its DNA hypomethylating effect0 aComparative study of dG affinity vs DNA methylation modulating p aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN a5350-53580 v63 a

Procainamide derivatives have been synthesized to investigate the role of side chains in modulating the DNA methylation level in cancer cells and gain insight into its mechanism of action. The synthesized derivatives comprised of flexible (dimethyl), constrained (pyrrolidine, piperidine, morpholine) and planar aromatic (pyridine, phenyl) side chain motifs. The affinity of procainamide and its derivatives towards the deoxyguanosine (dG) base in neutral form has been assessed by performing Differential Pulse Voltammetry (DPV) under physiological conditions. Further, molecular docking with hemimethylated CpG rich DNA acquired from an active mDNMT-1-DNA (PDB ID-4DA4) crystal structure, reveals their preferential non-covalent interaction with dG nucleobase in the intercalation cavity of the minor groove. Differential affinity of the derivatives to dG base in neutral and bound forms (DNA) is correlated with their DNA methylation modulating properties at sub-lethal concentrations. Among all the derivatives, a compound with an aromatic phenyl side chain (1) has shown a highest binding affinity for dG nucleobase in neutral form as well as for partially denatured CpG rich DNA which is attributed to the formation of p/p stacking interaction in addition to N-H/O hydrogen bonding with the pyrimidine ring of dG base. It also shows the highest cytotoxicity and global hypomethylation at a sub-lethal level in the MCF-7 cancer cell line compared to other derivatives and procainamide. A docking study has also illustrated the plausible structural basis of DNA methylation modulating a property of procainamide. Strong association of procainamide with dG bases of partially denatured CpG rich DNA via H-bonding and other non-covalent interactions may alter the active topology of DNA required by the DNA-binding regulatory proteins (e. g. DNMT-1) which is validated by a DNMT-1 inhibition assay. This systematic investigation leads to a new potent alternative to procainamide being found and gives a plausible insight into the DNA hypomethylating effect of procainamide.

1 aGawade, Rupesh, L.1 aChakravarty, Debamitra, K.1 aDebgupta, Joyashish1 aSangtani, E.1 aNarwade, S.1 aGonnade, Rajesh, G.1 aPuranik, Vedavati, G.1 aDeobagkar, D., D. uhttps://library.ncl.res.in/content/comparative-study-dg-affinity-vs-dna-methylation-modulating-properties-side-chain-0