01442nas a2200277   4500008004100000022001400041245013300055210006900188260006700257300001200324490000700336520045500343653002200798653002400820653001200844653002100856653002800877100002400905700002200929700001700951700002400968700001700992700001901009700001601028856012001044       2015                        eng d  a0899-004200aPreferential enrichment of DL-leucine using cocrystal formation with oxalic acid under nonequilibrium crystallization conditions0 aPreferential enrichment of DLleucine using cocrystal formation w  a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcJUL  a405-4100 v273 a<p>By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL-leucine (Leu) using a 1:1 cocrystal (DL-1) of DL-Leu and oxalic acid. The crystal structure analysis of DL-1 indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. Chirality 27:405-410 2015. (c) 2015 Wiley Periodicals, Inc.</p>10achiral resolution10acocrystal formation10aleucine10aphase transition10apreferential enrichment1 aManoj, Kochunnoonny1 aTakahashi, Hiroki1 aMorita, Yoko1 aGonnade, Rajesh, G.1 aIwama, Sekai1 aTsue, Hirohito1 aTamura, Rui  uhttps://library.ncl.res.in/content/preferential-enrichment-dl-leucine-using-cocrystal-formation-oxalic-acid-under-001821nas a2200265   4500008004100000022001400041245015000055210006900205260000900274300001100283490000900294520090200303653001301205653001501218653002201233653002801255653002801283100002401311700002201335700001701357700002001374700001901394700001601413856012601429       2021                        eng d  a0022-286000aCrystal structure analysis of highly efficient chiral resolution of (RS)-arginine-fumaric acid cocrystal under preferential enrichment conditions0 aCrystal structure analysis of highly efficient chiral resolution  cDEC   a1310730 v12453 aTwo new hydrate cocrystals, (RS)-arginine-fumaric acid-H2O ( 2 ) and (S)-arginine-2 fumaric acid-H2O ( 3 ), were obtained by the slow evaporation of the saturated aqueous ethanol solution of a 1:1 mixture of S-enriched arginine (33% ee) and fumaric acid or (S)-arginine and fumaric acid, respectively. Cocrystals 2 and 3 possess an isostructural molecular organization containing homochiral 1D chains of arginine sim-ilar to that of the anhydrous cocrystal of (RS)-arginine-fumaric acid ( 1 ). The latter showed an efficient ``preferential enrichment (PE)'', a unique spontaneous enantiomeric resolution phenomenon by simple recrystallization from the highly supersaturated solution. The formation of unstable cocrystals 2 and 3 seems to have played a crucial role in the enrichment of arginine in the mother liquor under PE crystal-lization conditions. (c) 2021 Elsevier B.V. All rights reserved.10aArginine10acocrystals10acrystal structure10aEnantiomeric resolution10apreferential enrichment1 aManoj, Kochunnoonny1 aTakahashi, Hiroki1 aIwama, Sekai1 aGonnade, Rajesh1 aTsue, Hirohito1 aTamura, Rui  uhttps://library.ncl.res.in/content/crystal-structure-analysis-highly-efficient-chiral-resolution-rs-arginine-fumaric-acid