02000nas a2200301   4500008004100000022001400041245009700055210006900152260000900221300000900230490000800239520101400247653001501261653004401276653000701320653001701327653003501344653001701379100001701396700001701413700002601430700002201456700002101478700003501499700001701534700002101551856012601572       2018                        eng d  a0254-058400apH dependent sophorolipid assemblies and their influence on gelation of silk fibroin protein0 apH dependent sophorolipid assemblies and their influence on gela  cJAN   a9-160 v2033 a<p>Sophorolipid (SL), a bio-derived surfactant is an excellent gelling agent for natural fibrous protein, silk fibroin (SF) leading to potential biomedical applications. Interaction of SF with SL has been shown to accelerate the formation of hydrogel with the rate being dependent on the form of SL used. Here, we examine the effect of pH on SL-SF interaction and gel formation by employing rheology, fluorescence spectroscopy, SANS and NMR. The results indicate that the size of SL assemblies decrease as pH increases from acidic to alkaline and significantly impacts the association of SL and SF. The association of SF and SL is mainly via hydrophobic interactions, with the SL molecules forming bead like structures along the SF chain. The increased charge on the acidic form of SL at higher pH results in greater repulsion between acidic SL molecules, which are bound to the hydrophobic sites of SF, leading to rapid chain unfolding and subsequent gelation. (C) 2017 Elsevier B.V. All rights reserved.</p>10aAssemblies10aNuclear magnetic resonance spectroscopy10apH10aSilk fibroin10aSmall angle neutron scattering10aSophorolipid1 aDubey, Parul1 aKumar, Sugam1 aRavindranathan, Sapna1 aVasudevan, Sahana1 aAswal, Vinod, K.1 aRajamohanan, Pattuparambil, R.1 aNisal, Anuya1 aPrabhune, Asmita  uhttps://library.ncl.res.in/content/ph-dependent-sophorolipid-assemblies-and-their-influence-gelation-silk-fibroin-protein01598nas a2200205   4500008004100000022001400041245011200055210006900167260000800236300001100244490000600255520088300261653001301144653001801157653002101175653001701196100002201213700002501235856013201260       2018                        eng d  a2054-570300aPhotophysical studies on curcumin-sophorolipid nanostructures: applications in quorum quenching and imaging0 aPhotophysical studies on curcuminsophorolipid nanostructures app  cFEB  a1708650 v53 a<p>Sophorolipid biosurfactants are biodegradable, less toxic and FDA approved. The purified acidic form of sophorolipid is stimuli-responsive with self-assembling properties and used for solubilizing hydrophobic drugs. This study encapsulated curcumin (CU) with acidic sophorolipid (ASL) micelles and analysed using photophysical studies like UV-visible spectroscopy, photoluminescence (PL) spectroscopy and timecorrelated single photon counting (TCSPC). TEM images have revealed ellipsoid micelles of approximately 100nm size and were confirmed by dynamic light scattering. The bacterial fluorescence uptake studies showed the uptake of formed CUASL nanostructures into both Gram-positive and Gram-negative bacteria. They also showed quorum quenching activity against Pseudomonas aeruginosa. The results have demonstrated this system has potential theranostic applications.</p>10acurcumin10aphotophysical10aQuorum quenching10aSophorolipid1 aVasudevan, Sahana1 aPrabhune, Asmita, A.  uhttps://library.ncl.res.in/content/photophysical-studies-curcumin-sophorolipid-nanostructures-applications-quorum-quenching-and