01812nas a2200349   4500008004100000022001400041245014800055210006900203260007700272300001600349490000700365520060800372653001600980653002200996653001501018653001901033653002201052100001701074700002101091700001501112700002401127700002401151700002101175700002201196700002101218700002701239700002201266700002201288700001901310700001601329856011701345       2014                        eng d  a0947-653900aHighly efficient chiral resolution of DL-arginine by cocrystal formation followed by recrystallization under preferential-enrichment conditions0 aHighly efficient chiral resolution of DLarginine by cocrystal fo  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG  a10343-103500 v203 a<p>An excellent chiral symmetry-breaking spontaneous enantiomeric resolution phenomenon, denoted preferential enrichment, was observed on recrystallization of the 1:1 cocrystal of dl-arginine and fumaric acid, which is classified as a racemic compound crystal with a high eutectic ee value (&gt;95%), under non-equilibrium crystallization conditions. On the basis of temperature-controlled video microscopy and in situ time-resolved solid-state (CNMR)-C-13 spectroscopic studies on the crystallization process, a new mechanism of phase transition that can induce preferential enrichment is proposed.</p>10aAmino acids10achiral resolution10acocrystals10aCrystal growth10aphase transitions1 aIwama, Sekai1 aKuyama, Kazunori1 aMori, Yuko1 aManoj, Kochunnoonny1 aGonnade, Rajesh, G.1 aSuzuki, Katsuaki1 aHughes, Colan, E.1 aWilliams, Andrew1 aHarris, Kenneth, D. M.1 aVeesler, Stephane1 aTakahashi, Hiroki1 aTsue, Hirohito1 aTamura, Rui  uhttps://library.ncl.res.in/content/highly-efficient-chiral-resolution-dl-arginine-cocrystal-formation-followed-001821nas a2200265   4500008004100000022001400041245015000055210006900205260000900274300001100283490000900294520090200303653001301205653001501218653002201233653002801255653002801283100002401311700002201335700001701357700002001374700001901394700001601413856012601429       2021                        eng d  a0022-286000aCrystal structure analysis of highly efficient chiral resolution of (RS)-arginine-fumaric acid cocrystal under preferential enrichment conditions0 aCrystal structure analysis of highly efficient chiral resolution  cDEC   a1310730 v12453 aTwo new hydrate cocrystals, (RS)-arginine-fumaric acid-H2O ( 2 ) and (S)-arginine-2 fumaric acid-H2O ( 3 ), were obtained by the slow evaporation of the saturated aqueous ethanol solution of a 1:1 mixture of S-enriched arginine (33% ee) and fumaric acid or (S)-arginine and fumaric acid, respectively. Cocrystals 2 and 3 possess an isostructural molecular organization containing homochiral 1D chains of arginine sim-ilar to that of the anhydrous cocrystal of (RS)-arginine-fumaric acid ( 1 ). The latter showed an efficient ``preferential enrichment (PE)'', a unique spontaneous enantiomeric resolution phenomenon by simple recrystallization from the highly supersaturated solution. The formation of unstable cocrystals 2 and 3 seems to have played a crucial role in the enrichment of arginine in the mother liquor under PE crystal-lization conditions. (c) 2021 Elsevier B.V. All rights reserved.10aArginine10acocrystals10acrystal structure10aEnantiomeric resolution10apreferential enrichment1 aManoj, Kochunnoonny1 aTakahashi, Hiroki1 aIwama, Sekai1 aGonnade, Rajesh1 aTsue, Hirohito1 aTamura, Rui  uhttps://library.ncl.res.in/content/crystal-structure-analysis-highly-efficient-chiral-resolution-rs-arginine-fumaric-acid