02089nas a2200289 4500008004100000022001400041245011400055210006900169260000900238300001200247490000800259520111300267653001401380653001801394653002001412653003401432653004901466653001301515653001701528100001801545700001901563700002201582700001701604700002201621700002501643856013101668 2018 eng d a0144-861700aElectrospinning of non-ionic cellulose ethers/polyvinyl alcohol nanofibers: characterization and applications0 aElectrospinning of nonionic cellulose etherspolyvinyl alcohol na cFEB  a175-1820 v1813 a

The morphology of spin-coated films and electrospun fibers of ethyl hydroxy ethyl cellulose (EHEC), hydrophobically modified ethyl hydroxy ethyl cellulose (HM-EHEC) and their blends with Poly(vinyl alcohol) (PVA) was examined by AFM, SEM and contact angle measurements. These polysaccharides upon blending with PVA exhibited smooth surface which was evidenced by Atomic Force Microscopy (AFM) observation. The electrospinnability of above polysaccharides with PVA was demonstrated for the first time. The oriented fibers could be obtained using a rotating disc collector. Contact angles of spin-coated films and electrospun fibers were discussed in terms of hydrophobicity and wetting characteristics. Further, The nanofibers of EHEC/PVA were in-situ crosslinked using citric acid and were used for controlled release of an antibacterial drug, Chlorhexidine Digluconate (ChD). In-vitro studies of cytotoxicity, cell growth and cell proliferation were performed using L929 mouse fibroblast cells. These nanofiber mats show potential in drug delivery and as scaffolds in tissue engineering applications.

10acellulose10adrug delivery10aelectrospinning10aEthyl hydroxy ethyl cellulose10aHydrophobically modified ethyl hydroxy ethyl10ascaffold10aSpin coating1 aWali, Ashwini1 aZhang, Yucheng1 aSengupta, Poulomi1 aHigaki, Yuji1 aTakahara, Atsushi1 aBadiger, Manohar, V. uhttps://library.ncl.res.in/content/electrospinning-non-ionic-cellulose-etherspolyvinyl-alcohol-nanofibers-characterization-and02118nas a2200181 4500008004100000245012900041210006900170260000800239300001600247490000600263520143700269100001801706700002001724700002001744700001701764700002501781856013001806 2019 eng d00aVivo wound healing performance of halloysite clay and gentamicin-incorporated cellulose ether-PVA electrospun nanofiber mats0 aVivo wound healing performance of halloysite clay and gentamicin cSEP a4324–43340 v23 a

Wound healing is a dynamic and complex process that requires a suitable environment to enhance the rapid healing process. In this context, fabrications of nanofibrous materials with antibiotic and antibacterial properties are becoming extremely important. In this present work, we report on the fabrication and characterization of electro-spun cellulose ether-PVA nanofiber mats loaded with halloysite clay (HNT) and gentamicin sulfate (GS) for faster wound healing applications. The morphology of nanofiber mats was examined by SEM and TEM. The average diameter of the nanofiber mats were in the range of 325 ± 30 nm. The physicochemical characterizations were done by FT-IR and XRD, which reveal the presence of HNT and GS into the nanofibers. The incorporation of halloysite gave good mechanical strength to the nanofiber mats. Swelling studies indicated the hydrophilicity of the mats. In vitro studies revealed that HNTs are nontoxic to L929 fibroblast cells and also promote cell growth and proliferation. The antibacterial property of HNT was also studied. The slow release of GS from the nanofiber mats was observed for a period of 18 days. The in vivo wound healing studies on the wistar rats for 21 days revealed the wound healing faster within 2 weeks by the incorporation of HNT and GS into the nanofiber mats and hence these nanofiber mats show great potential in acute and chronic wound healing applications.

1 aWali, Ashwini1 aGorain, Mahadeo1 aInamdar, Satish1 aKundu, Gopal1 aBadiger, Manohar, V. uhttps://library.ncl.res.in/content/vivo-wound-healing-performance-halloysite-clay-and-gentamicin-incorporated-cellulose-ether13257nas a2200169 45000080041000002450145000412100069001862600008002553000011002634900006002745201260500280100001812885700002012903700001712923700002112940856012612961 2024 eng d00aSilver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: synthesis, characterization and wound dressing applications0 aSilver nanoparticles in electrospun ethyl hydroxy ethyl cellulos cJUN a1004770 v73 a

Electrospinning is a simple, cost-effective technique and a reproducible process for both synthetic and natural polymers. It is found to be an attractive tool for various applications in biomedical engineering, filtration, protective clothing, catalysis reactions and sensors. Non-ionic cellulose ethers namely Ethyl Hydroxy Ethyl Cellulose (EHEC) is an important polysaccharide which is non-toxic, biocompatible and biodegradable and finds applications as thickening/rheology control agents in paints, cosmetics, detergents, oil recovery and also in the biomedical area. Poly (vinyl alcohol) (PVA) is a semi-crystalline hydrophilic polymer which is highly biocompatible and non-toxic having good thermal and mechanical properties and also high water solubility. Silver shows powerful antimicrobial activity and is non-toxic. It has been used to cure severe burns and chronic ulcers for many decades and is extensively used as an additive in various fields like prostheses, burn treatment, catheters, vascular grafts, dental resin components, ion exchange fibers, stainless steel materials, human skin and coating of medical devices. In the present work, EHEC/PVA nanofibers embedded with silver nanoparticles (AgNPs) are studied for their antibacterial activity using both gram positive and gram negative bacteria. The nanofibers show increase in tensile properties with the addition of silver nano-particles. The AgNPs embedded EHEC/PVA nanofiber mats having 0.5% AgNPs were found to enhance the wound healing with no scar formation in wistar rats. The biological in-vitro and in-vivo studies support the potential of EHEC based nanofibers as excellent bio-materials for the treatment of severe burns and wounds. To the best of our knowledge, this is the first report on the electrospinning of EHEC/PVA nanofibers for wound healing applications.

1 aWali, Ashwini1 aGorain, Mahadeo1 aKundu, Gopal1 aBadiger, Manohar uhttps://library.ncl.res.in/content/silver-nanoparticles-electrospun-ethyl-hydroxy-ethyl-cellulose-pva-nanofiber-synthesis02803nas a2200145 4500008004100000245013200041210006900173260000800242300001200250490000700262520221800269100001802487700002102505856013102526 2025 eng d00aMicrogels of hydrophobically modified-ethyl hydroxy ethyl cellulose (HM-EHEC) with 5-flurouracil for drug delivery applications0 aMicrogels of hydrophobically modifiedethyl hydroxy ethyl cellulo cAUG a212-2180 v203 a

The polysaccharides (e.g. celluloses and proteins) which form the basic building blocks of life, are gaining increased interest in recent times for researchers to develop newer health care products from renewable bio-polymers which are cheaper and easily available with different desirable properties. Gels are highly swollen three dimensional networks of hydrophilic polymers cross-linked by physical or chemical interactions. Our focus was to design and develop a novel microgel system which would effectively deliver the anti-cancer drug to the targeted site by slow and sustained release for longer times. The water soluble hydrophobically modified ethyl hydroxy ethyl cellulose (HM-EHEC) biopolymer was used in the synthesis of microgels by Michael-type addition reaction between the primary hydroxyl groups of HM-EHEC and Divinyl sulphone (DVS) crosslinker using water-in-oil emulsion technique. The microgels obtained were spherical in shape having flower type morphology with average size of 5 to 8 μm. The anti-cancer drug 5-Flurouracil (5-FU) drug was successfully incorporated and around 56% of the 5-FU was released in 72 hours with a loading efficiency of 95%.

The cell viability (MTT assay) studies confirmed the cycto-toxicity on the MDA-MB 231 breast cancer cell line. There was an increase in the cell death with increase in the concentration of microgel containing drug concentration. The HM-EHEC microgels could be effectively used in the form of a topical cream in the skin and breast cancer for on-site slow and targeted delivery.

1 aWali, Ashwini1 aBadiger, Manohar uhttps://library.ncl.res.in/content/microgels-hydrophobically-modified-ethyl-hydroxy-ethyl-cellulose-hm-ehec-5-flurouracil-drug