01041nas a2200229 4500008004100000022001400041245005200055210004600107260000800153300001200161490000700173520039500180653002700575653001700602653001600619653002100635653002000656653001300676100002500689700001900714856007800733 2018 eng d a0039-788100aFirst total synthesis of (+/-)-rhodoconferimide0 aFirst total synthesis of rhodoconferimide cFEB a658-6620 v503 a

Starting from vanillin and dimethyl maleate, a concise and efficient racemic total synthesis of the potent antioxidant marine natural product (+/-)-rhodoconferimide has been carried out via the Wittig reaction, catalytic hydrogenation, selective brominations, and imide formation. An appropriate regioselective double bromination of the aromatic ring was a key step in the synthesis.

10a(+/-)-rhodoconferimide10aAntioxidants10aBromination10aNatural products10aTotal synthesis10aVanillin1 aPandhade, Kailas, R.1 aArgade, N., P. uhttps://library.ncl.res.in/content/first-total-synthesis-rhodoconferimide