01450nas a2200241   4500008004100000022001400041245009000055210006900145260007500214300001400289490000700303520059000310653001400900653002400914653001600938653003100954653001800985653002401003653002001027100001901047700001901066856012301085       2012                        eng d  a0039-788100aSynthetic studies towards NG-121: diastereoselective synthesis of NG-121 methyl ether0 aSynthetic studies towards NG121 diastereoselective synthesis of   aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a3797-38040 v443 a<p>Starting from unsymmetrically O-protected methyl 4-bromo-3,5-dihydroxybenzoate, a facile synthesis of the methyl ether of bioactive natural product NG-121 was accomplished in very good overall yield. The key steps were: Stille coupling reaction of the farnesyl unit with the electron-rich phenolic segment; hydroxy-directed selective epoxidation of the farnesyl chain along with concomitant phenol-driven intramolecular regio- and diastereoselective ring closure to the corresponding hydroxybenzopyran; and regioselective formylation followed by in situ reductive lactonization.</p>10a4-bromo-310a5-dihydroxybenzoate10aformylation10aintramolecular cyclization10alactonization10aNG-121 methyl ether10aStille coupling1 aSingh, Mandeep1 aArgade, N., P.  uhttps://library.ncl.res.in/content/synthetic-studies-towards-ng-121-diastereoselective-synthesis-ng-121-methyl-ether-0