01328nas a2200217   4500008004100000022001400041245010100055210006900156260007500225300001400300490000700314520048900321653003500810653001300845653003600858653002900894653001400923100002300937700001900960856013100979       2013                        eng d  a0039-788100aBiology-orientated synthesis of putrescine bisamides gigantamide A, dasyclamide, and cucullamide0 aBiologyorientated synthesis of putrescine bisamides gigantamide   aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcOCT  a2888-28920 v453 a<p>Starting from putrescine and the requisite carboxylic acids, first syntheses of bioactive natural products gigantamide A, dasyclamide, and cucullamide were accomplished in very good overall yields using an appropriate sequence of dehydrative coupling reactions. The syntheses of the corresponding dehomo analogues of these natural products are also described. Regioselective diisobutylaluminum hydride reduction of an unhindered carbonyl group in citraconimide is the key step.</p>10adehydrative coupling reactions10adiamines10anatural and unnatural bisamides10aregioselective reduction10asynthesis1 aBatwal, Ramesh, U.1 aArgade, N., P.  uhttps://library.ncl.res.in/content/biology-orientated-synthesis-putrescine-bisamides-gigantamide-dasyclamide-and-cucullamide-0