01232nas a2200145   4500008004100000022001400041245013600055210006900191260000800260490000600268520064600274100001900920700001900939856012800958       2017                        eng d  a2470-134300aTotal synthesis of bioactive canthine alkaloid cordatanine comprising in situ double oxidative aromatization of tetrahydrocarbazole0 aTotal synthesis of bioactive canthine alkaloid cordatanine compr  cJUL0 v23 a<p><span style="color: rgb(80, 80, 80); font-family: NexusSan, Arial, Georgia, sans-serif, serif; font-size: 16px;">Starting from tryptamine and methoxymaleic anhydride, concise and efficient total synthesis of cordatanine has been accomplished via regioselective reduction of methoxymaleimide, acid-catalyzed intramolecular cyclization of the formed lactamol, in situ stepwise oxidations leading to aromatization, and intramolecular cyclization with the exchange of N-regioselectivity. An attempted synthesis of regioisomeric natural product zanthochilone has been described in brief with reversal of reduction selectivity.&nbsp;</span></p>1 aShelar, S., V.1 aArgade, N., P.  uhttps://library.ncl.res.in/content/total-synthesis-bioactive-canthine-alkaloid-cordatanine-comprising-situ-double-oxidative