02222nas a2200253   4500008004100000022001400041245012100055210006900176260000800245490000700253520137600260653002701636653002701663653001701690653001301707653002201720100001901742700001501761700002101776700001501797700001501812700001901827856012201846       2017                        eng d  a1054-252300aSynthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives0 aSynthesis antitubercular and antimicrobial potential of some new  cJUN0 v263 a<p>The increase in antibiotic resistance due to multiple factors has warranted the need for the search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent. © 2017, Springer Science+Business Media, LLC.</p>10aAntimicrobial activity10aAntitubercular activit10aCytotoxicity10aThiazole10aThiosemicarbazide1 aAbhale, Y., K.1 aShinde, A.1 aDeshmukh, K., K.1 aNawale, L.1 aSarkar, D.1 aMhaske, P., C.  uhttps://library.ncl.res.in/content/synthesis-antitubercular-and-antimicrobial-potential-some-new-thiazole-substituted